dbPTM

FLIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLIP1_HUMAN
UniProt AC	Q7Z7B0
Protein Name	Filamin-A-interacting protein 1
Gene Name	FILIP1
Organism	Homo sapiens (Human).
Sequence Length	1213
Subcellular Localization	Cytoplasm, cytoskeleton .
Protein Description	By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A..
Protein Sequence	MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKSAASSTTSLGGGKG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	O-linked_Glycosylation	IGNAGEKSLSEDAKK CCCCCCCCCCHHHHH	32.59	30379171
31	Phosphorylation	IGNAGEKSLSEDAKK CCCCCCCCCCHHHHH	32.59	26437602
33	O-linked_Glycosylation	NAGEKSLSEDAKKKK CCCCCCCCHHHHHHH	40.29	30379171
39	Methylation	LSEDAKKKKKSNRKE CCHHHHHHHHCCCHH	65.80	-
39	"N6,N6-dimethyllysine"	LSEDAKKKKKSNRKE CCHHHHHHHHCCCHH	65.80	-
42	Phosphorylation	DAKKKKKSNRKEDDV HHHHHHHCCCHHHCH	51.23	27251275
52	Phosphorylation	KEDDVMASGTVKRHL HHHCHHCHHHHHHHH	19.53	28857561
54	Phosphorylation	DDVMASGTVKRHLKT HCHHCHHHHHHHHCC	21.99	28857561
138	Phosphorylation	AILAQEKSIGEDVYE HHHHHHCCCCCCHHH	34.76	26657352
196	Methylation	KHTDYMNKSDDFTNL CCCCCCCCCHHHHHH	38.44	-
196	Ubiquitination	KHTDYMNKSDDFTNL CCCCCCCCCHHHHHH	38.44	22505724
265	Phosphorylation	IEQLGLQSQKVQDLT HHHHHCHHHHHHHHH	36.69	-
267	Ubiquitination	QLGLQSQKVQDLTQK HHHCHHHHHHHHHHH	47.30	30230243
270	Ubiquitination	LQSQKVQDLTQKLRE CHHHHHHHHHHHHHH	55.46	30230243
272	Phosphorylation	SQKVQDLTQKLREEE HHHHHHHHHHHHHHH	31.76	-
444	Ubiquitination	KLEEAFSKSKSECTQ HHHHHHHCCHHHHHH	56.29	22505724
447	Ubiquitination	EAFSKSKSECTQLHL HHHHCCHHHHHHHHH	45.02	22505724
499	Phosphorylation	LSLKDDLTKLKSFTV HCCCHHHHHHHHEEE	41.13	23403867
559	Phosphorylation	KKLLKLKSEMEEKVY HHHHHHHHHHHHHHH	53.24	29743597
566	Phosphorylation	SEMEEKVYNLTRERD HHHHHHHHHHHHHHH	18.60	29743597
619	Phosphorylation	RGRSRKGSELTCPED CCCCCCCCCCCCCCC	32.25	26657352
622	Phosphorylation	SRKGSELTCPEDNKI CCCCCCCCCCCCCCH	23.20	25002506
633	Phosphorylation	DNKIKELTLEIERLK CCCHHHHHHHHHHHH	24.36	-
655	Ubiquitination	VVEGDLMKTEDEYDQ CCCCCCCCCHHHHHH	56.94	-
779	Phosphorylation	LTKELELSKRYSRAL HHHHHHHHHHHHHHH	13.00	30576142
789	Phosphorylation	YSRALRPSVNGRRMV HHHHHCCCCCCEEEE	23.06	28348404
801	Phosphorylation	RMVDVPVTSTGVQTD EEEEECEECCCEECC	17.94	28165663
807	Phosphorylation	VTSTGVQTDAVSGEA EECCCEECCCCCCCC	24.42	22817900
811	Phosphorylation	GVQTDAVSGEAAEEE CEECCCCCCCCCCCC	32.41	22817900
819	Phosphorylation	GEAAEEETPAVFIRK CCCCCCCCCEEEEEH	21.59	22817900
836	Phosphorylation	QEENHIMSNLRQVGL HHHCCHHHHHHHCCC	31.91	29083192
881	Phosphorylation	RKRENGPSITQEKGP HHCCCCCCCCCCCCC	39.40	26074081
883	Phosphorylation	RENGPSITQEKGPRT CCCCCCCCCCCCCCC	34.71	26074081
903	Phosphorylation	HPGEVVLSPKQGQPL CCCCEEECCCCCCCE	20.59	23312004
928	Phosphorylation	STATLEITSPTSEEF CCEEEEECCCCCHHH	21.19	27251275
929	Phosphorylation	TATLEITSPTSEEFF CEEEEECCCCCHHHH	31.66	27251275
931	Phosphorylation	TLEITSPTSEEFFSS EEEECCCCCHHHHCC	48.84	26657352
932	Phosphorylation	LEITSPTSEEFFSST EEECCCCCHHHHCCC	38.21	27251275
957	Phosphorylation	PRITIIPSPNVMPQK CCEEEECCCCCCCCC	20.78	28555341
967	Phosphorylation	VMPQKQKSGDTTLGP CCCCCCCCCCCCCCC	39.13	26437602
970	Phosphorylation	QKQKSGDTTLGPERA CCCCCCCCCCCCHHC	27.69	22673903
979	Phosphorylation	LGPERAMSPVTITTF CCCHHCCCCEEEEEE	18.42	23403867
982	Phosphorylation	ERAMSPVTITTFSRE HHCCCCEEEEEEECC	18.91	23403867
984	Phosphorylation	AMSPVTITTFSREKT CCCCEEEEEEECCCC	16.66	23403867
985	Phosphorylation	MSPVTITTFSREKTP CCCEEEEEEECCCCC	18.76	-
987	Phosphorylation	PVTITTFSREKTPES CEEEEEEECCCCCCC	37.12	-
1004	Phosphorylation	GAFADRPTSPIQIMT CCCCCCCCCCEEEEE	48.29	28857561
1005	Phosphorylation	AFADRPTSPIQIMTV CCCCCCCCCEEEEEE	23.76	26657352
1011	Phosphorylation	TSPIQIMTVSTSAAP CCCEEEEEEECCCCC	16.97	26074081
1013	Phosphorylation	PIQIMTVSTSAAPAE CEEEEEEECCCCCCE	13.89	26074081
1014	Phosphorylation	IQIMTVSTSAAPAEI EEEEEEECCCCCCEE	20.32	26074081
1015	Phosphorylation	QIMTVSTSAAPAEIA EEEEEECCCCCCEEE	18.22	26074081
1024	Phosphorylation	APAEIAVSPESQEMP CCCEEEECHHHCCCC	17.58	26074081
1027	Phosphorylation	EIAVSPESQEMPMGR EEEECHHHCCCCCCC	34.52	26074081
1035	Phosphorylation	QEMPMGRTILKVTPE CCCCCCCEEEECCCC	25.57	-
1040	Phosphorylation	GRTILKVTPEKQTVP CCEEEECCCCCCCCC	24.92	21712546
1045	Phosphorylation	KVTPEKQTVPTPVRK ECCCCCCCCCCCCCC	39.25	22817900
1048	Phosphorylation	PEKQTVPTPVRKYNS CCCCCCCCCCCCCCC	30.04	21712546
1053	Phosphorylation	VPTPVRKYNSNANII CCCCCCCCCCCCCEE	17.17	-
1078	Phosphorylation	LGSQFKRSPGTSGEG ECCCCCCCCCCCCCC	28.42	24667141
1082	Phosphorylation	FKRSPGTSGEGVSPV CCCCCCCCCCCCCCE	40.54	26437602
1087	Phosphorylation	GTSGEGVSPVITVRP CCCCCCCCCEEEEEE	25.06	28555341
1091	Phosphorylation	EGVSPVITVRPVNVT CCCCCEEEEEECCEE	15.65	24667141
1098	Phosphorylation	TVRPVNVTAEKEVST EEEECCEEEEEEECC	24.72	24667141
1104	O-linked_Glycosylation	VTAEKEVSTGTVLRS EEEEEEECCCCEEEC	23.39	30379171
1107	Phosphorylation	EKEVSTGTVLRSPRN EEEECCCCEEECCCC	19.22	22210691
1111	Phosphorylation	STGTVLRSPRNHLSS CCCCEEECCCCCCCC	24.85	26437602
1128	Phosphorylation	GASKVTSTITITPVT CCCCCCEEEEEEEEE	16.87	22210691
1130	Phosphorylation	SKVTSTITITPVTTS CCCCEEEEEEEEECC	20.91	25693802
1130	O-linked_Glycosylation	SKVTSTITITPVTTS CCCCEEEEEEEEECC	20.91	30379171
1132	Phosphorylation	VTSTITITPVTTSSA CCEEEEEEEEECCCC	11.76	25693802
1135	Phosphorylation	TITITPVTTSSARGT EEEEEEEECCCCCCC	23.36	23403867
1135	O-linked_Glycosylation	TITITPVTTSSARGT EEEEEEEECCCCCCC	23.36	30379171
1136	Phosphorylation	ITITPVTTSSARGTQ EEEEEEECCCCCCCC	22.40	23403867
1137	Phosphorylation	TITPVTTSSARGTQS EEEEEECCCCCCCCC	16.79	25693802
1138	Phosphorylation	ITPVTTSSARGTQSV EEEEECCCCCCCCCC	21.64	25693802
1144	Phosphorylation	SSARGTQSVSGQDGS CCCCCCCCCCCCCCC	20.35	22210691
1151	Phosphorylation	SVSGQDGSSQRPTPT CCCCCCCCCCCCCCC	31.42	23403867
1152	Phosphorylation	VSGQDGSSQRPTPTR CCCCCCCCCCCCCCC	35.42	23403867
1158	Phosphorylation	SSQRPTPTRIPMSKG CCCCCCCCCCCCCCC	43.65	-
1200	Phosphorylation	MKIELKKSAASSTTS EEEEEHHHHCCCCCC	27.72	-
1204	Phosphorylation	LKKSAASSTTSLGGG EHHHHCCCCCCCCCC	30.86	24043423
1205	Phosphorylation	KKSAASSTTSLGGGK HHHHCCCCCCCCCCC	20.22	24043423
1206	Phosphorylation	KSAASSTTSLGGGKG HHHCCCCCCCCCCCC	24.73	24043423
1207	Phosphorylation	SAASSTTSLGGGKG- HHCCCCCCCCCCCC-	25.71	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MKRN1	Q9UHC7	PMID:19536131

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FLIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSF1_HUMAN	HSF1	physical	21784850
FLIP1_HUMAN	FILIP1	physical	21784850
RD23A_HUMAN	RAD23A	physical	21784850
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLIP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-807; SER-811 ANDTHR-819, AND MASS SPECTROMETRY.	18187866 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1045, AND MASSSPECTROMETRY.	15302935 [Abstract]