F1142_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F1142_HUMAN
• UniProt AC: Q9NRY5
• Protein Name: Protein FAM114A2
• Gene Name: FAM114A2
• Organism: Homo sapiens (Human).
• Sequence Length: 505
• Protein Sequence: MSDKDDIETPLLTEAAPILEDGNCEPAKNSESVDQGAKPESKSEPVVSTRKRPETKPSSDLETSKVLPIQDNVSKDVPQTRWGYWGSWGKSILSSASATVATVGQGISNVIEKAETSLGIPGPSEISTEVKYVAGETNAKENENSSPVAGAFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRNATLSQVLREAKEKEEIRTSNEVTVETDKKTHYGLLFDEFQGLSHLEALEMLSQESEIKVKSILNSLSGEELETLKVELEQLKETFSLAEFCEEEEEEKKGDEDFTKDITELFSQLHVSSKPEKLARARNTAHEWIRKSLTKPLAENEEGEKQSEAENTEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSQTLSQMTIVLCKELSSLSKEFTTCLTTAGVKEMADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISLIENKIESHRHELQGQKPLLEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDKDDIET ------CCCHHHCCC	54.06	22617229
9	Phosphorylation	SDKDDIETPLLTEAA CCHHHCCCCCCCCCC	21.41	28450419
13	Phosphorylation	DIETPLLTEAAPILE HCCCCCCCCCCCCCC	31.12	28450419
48	Phosphorylation	SKSEPVVSTRKRPET CCCCCCCCCCCCCCC	23.80	27251275
49	Phosphorylation	KSEPVVSTRKRPETK CCCCCCCCCCCCCCC	28.71	27251275
55	Phosphorylation	STRKRPETKPSSDLE CCCCCCCCCCCCCCC	51.44	27251275
58	Phosphorylation	KRPETKPSSDLETSK CCCCCCCCCCCCCCC	37.73	27251275
59	Phosphorylation	RPETKPSSDLETSKV CCCCCCCCCCCCCCE	55.53	30631047
63	Phosphorylation	KPSSDLETSKVLPIQ CCCCCCCCCCEECCC	40.94	28555341
64	Phosphorylation	PSSDLETSKVLPIQD CCCCCCCCCEECCCC	16.05	28555341
74	Phosphorylation	LPIQDNVSKDVPQTR ECCCCCCCCCCCCCC	29.41	30631047
75	Ubiquitination	PIQDNVSKDVPQTRW CCCCCCCCCCCCCCC	59.47	-
80	Phosphorylation	VSKDVPQTRWGYWGS CCCCCCCCCCCCCCH	23.48	-
84	Phosphorylation	VPQTRWGYWGSWGKS CCCCCCCCCCHHHHH	10.31	23186163
87	Phosphorylation	TRWGYWGSWGKSILS CCCCCCCHHHHHHHH	20.64	22617229
91	Phosphorylation	YWGSWGKSILSSASA CCCHHHHHHHHHCCC	25.48	25693802
94	Phosphorylation	SWGKSILSSASATVA HHHHHHHHHCCCEEE	23.37	25693802
95	Phosphorylation	WGKSILSSASATVAT HHHHHHHHCCCEEEE	23.85	25693802
97	Phosphorylation	KSILSSASATVATVG HHHHHHCCCEEEECC	26.81	25693802
99	Phosphorylation	ILSSASATVATVGQG HHHHCCCEEEECCCH	14.26	25693802
102	Phosphorylation	SASATVATVGQGISN HCCCEEEECCCHHHH	22.34	25693802
117	Phosphorylation	VIEKAETSLGIPGPS HHHHHHHHCCCCCHH	18.99	28555341
132	Phosphorylation	EISTEVKYVAGETNA HHCCEEEEEECCCCC	10.74	30624053
137	Phosphorylation	VKYVAGETNAKENEN EEEEECCCCCCCCCC	39.29	19690332
145	Phosphorylation	NAKENENSSPVAGAF CCCCCCCCCCCCHHH	29.82	30278072
146	Phosphorylation	AKENENSSPVAGAFG CCCCCCCCCCCHHHH	34.67	30278072
156	Phosphorylation	AGAFGVFSTISTAVQ CHHHHHHHHHHHHHH	23.56	29632367
157	Phosphorylation	GAFGVFSTISTAVQS HHHHHHHHHHHHHHH	13.90	29632367
159	Phosphorylation	FGVFSTISTAVQSTG HHHHHHHHHHHHHHC	15.48	29632367
160	Phosphorylation	GVFSTISTAVQSTGK HHHHHHHHHHHHHCC	27.31	23186163
164	Phosphorylation	TISTAVQSTGKSVIS HHHHHHHHHCCCHHH	32.31	28787133
165	Phosphorylation	ISTAVQSTGKSVISG HHHHHHHHCCCHHHC	31.38	28787133
182	Ubiquitination	DALEFIGKKTMDVIA HHHHHCCHHHHHHHH	40.01	-
196	Acetylation	AEGDPGFKRTKGLMN HCCCCCCCHHHCHHC	66.14	19852147
196	Methylation	AEGDPGFKRTKGLMN HCCCCCCCHHHCHHC	66.14	-
207	Phosphorylation	GLMNRNATLSQVLRE CHHCCCCCHHHHHHH	30.41	26074081
209	Phosphorylation	MNRNATLSQVLREAK HCCCCCHHHHHHHHH	17.56	23401153
223	Phosphorylation	KEKEEIRTSNEVTVE HHHHHHHCCCCEEEE	41.38	29116813
224	Phosphorylation	EKEEIRTSNEVTVET HHHHHHCCCCEEEEE	22.57	29116813
228	Phosphorylation	IRTSNEVTVETDKKT HHCCCCEEEEECCCC	13.37	29116813
231	Phosphorylation	SNEVTVETDKKTHYG CCCEEEEECCCCEEE	49.10	29116813
265	Ubiquitination	QESEIKVKSILNSLS CCCHHHHHHHHHHCC	27.12	-
270	Phosphorylation	KVKSILNSLSGEELE HHHHHHHHCCHHHHH	22.07	27499020
272	Phosphorylation	KSILNSLSGEELETL HHHHHHCCHHHHHHH	43.93	30622161
291	Phosphorylation	EQLKETFSLAEFCEE HHHHHHCCHHHHHHH	33.80	27251275
310	Phosphorylation	KKGDEDFTKDITELF HCCCCCHHHHHHHHH	39.88	24719451
323	Phosphorylation	LFSQLHVSSKPEKLA HHHHHHCCCCHHHHH	23.15	24719451
324	Phosphorylation	FSQLHVSSKPEKLAR HHHHHCCCCHHHHHH	51.66	24719451
343	Phosphorylation	AHEWIRKSLTKPLAE HHHHHHHHHCCCCCC	31.27	28450419
345	Phosphorylation	EWIRKSLTKPLAENE HHHHHHHCCCCCCCC	37.39	28450419
405	Malonylation	ALVLHGRKQEVTAIE HHHHCCCHHHEEHHH	56.24	32601280
500	Ubiquitination	RHELQGQKPLLEH-- HHHHCCCCCCCCC--	44.45	-
500	Acetylation	RHELQGQKPLLEH-- HHHHCCCCCCCCC--	44.45	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F1142_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F1142_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F1142_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.
PubMed: 19690332