| UniProt ID | ASB12_HUMAN | |
|---|---|---|
| UniProt AC | Q8WXK4 | |
| Protein Name | Ankyrin repeat and SOCS box protein 12 | |
| Gene Name | ASB12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 309 | |
| Subcellular Localization | ||
| Protein Description | Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.. | |
| Protein Sequence | MNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLDHGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSLSLDLTSQDDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLKHQL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | QALNQAVYDNDSYTL HHHHHHHHCCCCCCH | 16.43 | - | |
| 39 | Phosphorylation | QAVYDNDSYTLDQLL HHHHCCCCCCHHHHH | 26.69 | - | |
| 40 | Phosphorylation | AVYDNDSYTLDQLLR HHHCCCCCCHHHHHH | 17.74 | - | |
| 177 | Phosphorylation | ASCSGPLYLAAVYGH HCCCHHHHHHHHHCH | 9.45 | - | |
| 182 | Phosphorylation | PLYLAAVYGHLDCFR HHHHHHHHCHHHHHH | 8.29 | - | |
| 273 | Phosphorylation | ATPRSLLSQVRLVVR CCCHHHHHHHHHHHH | 31.74 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASB12_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASB12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASB12_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CUL5_HUMAN | CUL5 | physical | 16325183 | |
| RBX2_HUMAN | RNF7 | physical | 16325183 | |
| PROF1_HUMAN | PFN1 | physical | 24337577 | |
| PROF2_HUMAN | PFN2 | physical | 24337577 | |
| ACTB_HUMAN | ACTB | physical | 24337577 | |
| ELOC_HUMAN | TCEB1 | physical | 24337577 | |
| ELOB_HUMAN | TCEB2 | physical | 24337577 | |
| PRP16_HUMAN | DHX38 | physical | 24337577 | |
| SFPQ_HUMAN | SFPQ | physical | 24337577 | |
| MYH10_HUMAN | MYH10 | physical | 24337577 | |
| RL38_HUMAN | RPL38 | physical | 24337577 | |
| RBM10_HUMAN | RBM10 | physical | 24337577 | |
| PRDX6_HUMAN | PRDX6 | physical | 24337577 | |
| SRRT_HUMAN | SRRT | physical | 24337577 | |
| C1TM_HUMAN | MTHFD1L | physical | 24337577 | |
| RBM6_HUMAN | RBM6 | physical | 24337577 | |
| CAPS2_HUMAN | CADPS2 | physical | 24337577 | |
| EFTU_HUMAN | TUFM | physical | 24337577 | |
| KCRB_HUMAN | CKB | physical | 24337577 | |
| DHX36_HUMAN | DHX36 | physical | 24337577 | |
| F263_HUMAN | PFKFB3 | physical | 24337577 | |
| CPSF5_HUMAN | NUDT21 | physical | 24337577 | |
| FIBG_HUMAN | FGG | physical | 24337577 | |
| K2C8_HUMAN | KRT8 | physical | 24337577 | |
| RCN2_HUMAN | RCN2 | physical | 24337577 | |
| AIFM1_HUMAN | AIFM1 | physical | 24337577 | |
| LGUL_HUMAN | GLO1 | physical | 24337577 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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