ANR53_HUMAN - dbPTM
ANR53_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ANR53_HUMAN
UniProt AC Q8N9V6
Protein Name Ankyrin repeat domain-containing protein 53
Gene Name ANKRD53
Organism Homo sapiens (Human).
Sequence Length 530
Subcellular Localization Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Localizes at the spindle around the centrosome at prophase and prometaphase and at the spindle poles at metaphase and anaphase (PubMed:26820536).
Protein Description Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization..
Protein Sequence MASAGSTARRAGSGSWHSERGEGRGARPQPTPSGSMQQANKVSLKATWTDAESKQPSQPLPDLADHLSAQATALARPRRPASLTPPRADPSPSKESDQTAIDQTAIGSYYQLFAAAVGNVEWLRFCLNQSLREIPTDDKGFTAIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDKKDFAREMTKMKMFKSQLTLMEHNYLIEYQKEHKILREAAIRKWLHGKLHPGHSLVSNTKQARATALSKTPEQRESQRSRSFHPSVDARLQCIPQPTEMPKPIYRKPTVKRPTMWNVSNNPARPPTTQISHSQGIRLGVHPDPTPEHDFSSFLEVRPDGHGGARLHTVDGHWVAPVPRLPFEVLLRMLYPRVWPYRMKVPQGFYPISMREVPRKRHLGDNTFWTDTLAMNLRDTFDEAFLAAVRSHQGLPTLPSPQTNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MASAGSTARRAGSG
-CCCCCCCCCCCCCC		24.2222210691
13PhosphorylationSTARRAGSGSWHSER
CCCCCCCCCCCCCCC		28.7746164407
15PhosphorylationARRAGSGSWHSERGE
CCCCCCCCCCCCCCC		24.2646164411
82PhosphorylationARPRRPASLTPPRAD
HCCCCCHHCCCCCCC		35.1422184985
84PhosphorylationPRRPASLTPPRADPS
CCCCHHCCCCCCCCC		28.847915377
91PhosphorylationTPPRADPSPSKESDQ
CCCCCCCCCCCCCCC		42.219889021
93PhosphorylationPRADPSPSKESDQTA
CCCCCCCCCCCCCCC		54.089889029
280PhosphorylationKDFAREMTKMKMFKS
HHHHHHHHHHHHHHH		24.1926074081
287PhosphorylationTKMKMFKSQLTLMEH
HHHHHHHHHHHHHHH		21.1126074081
290PhosphorylationKMFKSQLTLMEHNYL
HHHHHHHHHHHHHHH		19.2026074081
296PhosphorylationLTLMEHNYLIEYQKE
HHHHHHHHHHHHHHH		15.8026074081
300PhosphorylationEHNYLIEYQKEHKIL
HHHHHHHHHHHHHHH		20.2126074081
336PhosphorylationNTKQARATALSKTPE
CCHHHHHHHHHCCHH		23.6846164419
368PhosphorylationLQCIPQPTEMPKPIY
HCCCCCCCCCCCCCC		39.4024144214
516PhosphorylationAFLAAVRSHQGLPTL
HHHHHHHHCCCCCCC		17.3524719451
522PhosphorylationRSHQGLPTLPSPQTN
HHCCCCCCCCCCCCC		57.2425693802
525PhosphorylationQGLPTLPSPQTNP--
CCCCCCCCCCCCC--		32.5246164415
528PhosphorylationPTLPSPQTNP-----
CCCCCCCCCC-----		53.4925693802
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ANR53_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ANR53_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ANR53_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ANR53_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ANR53_HUMAN

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Related Literatures of Post-Translational Modification

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