ZNRF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNRF4_HUMAN
• UniProt AC: Q8WWF5
• Protein Name: E3 ubiquitin-protein ligase ZNRF4 {ECO:0000305}
• Gene Name: ZNRF4 {ECO:0000312|HGNC:HGNC:17726}
• Organism: Homo sapiens (Human).
• Sequence Length: 429
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
• Protein Description: E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. [PubMed: 21205830 Could have a role in spermatogenesis (By similarity]
• Protein Sequence: MPLCRPEHLMPRASRVPVAASLPLSHAVIPTQLPSRPGHRPPGRPRRCPKASCLPPPVGPSSTQTAKRVTMGWPRPGRALVAVKALLVLSLLQVPAQAVVRAVLEDNSSSVDFADLPALFGVPLAPEGIRGYLMEVKPANACHPIEAPRLGNRSLGAIVLIRRYDCTFDLKVLNAQRAGFEAAIVHNVHSDDLVSMTHVYEDLRGQIAIPSVFVSEAASQDLRVILGCNKSAHALLLPDDPPCHDLGCHPVLTVSWVLGCTLALVVSAFFVLNHLWLWAQACCSHRRPVKTSTCQKAQVRTFTWHNDLCAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAATEDSFDSTTYSFRDEDPSLPGHRPPIWAIQVQLRSRRLELLGRASPHCHCSTTSLEAEYTTVSSAPPEAPGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	TQTAKRVTMGWPRPG CCCCCEEECCCCCCH	17.63	-
107	N-linked_Glycosylation	VRAVLEDNSSSVDFA HHHHHCCCCCCCCHH	34.12	21205830
152	N-linked_Glycosylation	IEAPRLGNRSLGAIV CCCCCCCCCCCCEEE	34.65	21205830
229	N-linked_Glycosylation	LRVILGCNKSAHALL CCHHCCCCCCCCEEE	39.25	21205830
253	Phosphorylation	LGCHPVLTVSWVLGC CCCCCCHHHHHHHHH	16.84	26074081
255	Phosphorylation	CHPVLTVSWVLGCTL CCCCHHHHHHHHHHH	13.26	26074081
261	Phosphorylation	VSWVLGCTLALVVSA HHHHHHHHHHHHHHH	17.17	26074081
267	Phosphorylation	CTLALVVSAFFVLNH HHHHHHHHHHHHHHH	16.33	26074081
402	Phosphorylation	LELLGRASPHCHCST HHHHHCCCCCCCCCC	17.51	25693802
408	Phosphorylation	ASPHCHCSTTSLEAE CCCCCCCCCCEEEEE	15.85	25693802
409	Phosphorylation	SPHCHCSTTSLEAEY CCCCCCCCCEEEEEE	26.29	25693802
410	Phosphorylation	PHCHCSTTSLEAEYT CCCCCCCCEEEEEEE	18.28	25693802
411	Phosphorylation	HCHCSTTSLEAEYTT CCCCCCCEEEEEEEE	25.05	25693802
416	Phosphorylation	TTSLEAEYTTVSSAP CCEEEEEEEECCCCC	18.11	25693802
417	Phosphorylation	TSLEAEYTTVSSAPP CEEEEEEEECCCCCC	16.54	25693802
418	Phosphorylation	SLEAEYTTVSSAPPE EEEEEEEECCCCCCC	19.93	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNRF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNRF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNRF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALX_HUMAN	CANX	physical	21205830
RL40_HUMAN	UBA52	physical	28514442
DGLA_HUMAN	DAGLA	physical	28514442
ABCA2_HUMAN	ABCA2	physical	28514442
AREL1_HUMAN	AREL1	physical	28514442
FZD6_HUMAN	FZD6	physical	28514442
PDZD8_HUMAN	PDZD8	physical	28514442
KCNT2_HUMAN	KCNT2	physical	28514442
KCNG1_HUMAN	KCNG1	physical	28514442
ST7L_HUMAN	ST7L	physical	28514442
ADCK2_HUMAN	ADCK2	physical	28514442
C2C2L_HUMAN	C2CD2L	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
BT2A2_HUMAN	BTN2A2	physical	28514442
OSBP1_HUMAN	OSBP	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
GRM1A_HUMAN	GRAMD1A	physical	28514442
PCX3_HUMAN	PCNXL3	physical	28514442
PDE3B_HUMAN	PDE3B	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
S27A6_HUMAN	SLC27A6	physical	28514442
S12A6_HUMAN	SLC12A6	physical	28514442
UBP33_HUMAN	USP33	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
ERN1_HUMAN	ERN1	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
P121A_HUMAN	POM121	physical	28514442
UPK3L_HUMAN	UPK3BL	physical	28514442
ERG1_HUMAN	SQLE	physical	28514442
TMM68_HUMAN	TMEM68	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
SUN2_HUMAN	SUN2	physical	28514442
F189B_HUMAN	FAM189B	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
ITPR2_HUMAN	ITPR2	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
SRBP2_HUMAN	SREBF2	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
ABCA3_HUMAN	ABCA3	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
VRK2_HUMAN	VRK2	physical	28514442
S12A7_HUMAN	SLC12A7	physical	28514442
SUN1_HUMAN	SUN1	physical	28514442
TMX2_HUMAN	TMX2	physical	28514442
YIF1A_HUMAN	YIF1A	physical	28514442
SEC20_HUMAN	BNIP1	physical	28514442
AMFR_HUMAN	AMFR	physical	28514442
MARC1_HUMAN	MARC1	physical	28514442
PTPRU_HUMAN	PTPRU	physical	28514442
SGPL1_HUMAN	SGPL1	physical	28514442
PLPL6_HUMAN	PNPLA6	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
S27A3_HUMAN	SLC27A3	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
SCAP_HUMAN	SCAP	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
CGRF1_HUMAN	CGRRF1	physical	28514442
DJC18_HUMAN	DNAJC18	physical	28514442
NB5R1_HUMAN	CYB5R1	physical	28514442
ST7_HUMAN	ST7	physical	28514442
NETO2_HUMAN	NETO2	physical	28514442
ANO6_HUMAN	ANO6	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
AT132_HUMAN	ATP13A2	physical	28514442
BT2A1_HUMAN	BTN2A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.