| UniProt ID | KCNG1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UIX4 | |
| Protein Name | Potassium voltage-gated channel subfamily G member 1 | |
| Gene Name | KCNG1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 513 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). |
|
| Protein Description | Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. [PubMed: 19074135] | |
| Protein Sequence | MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 251 | Phosphorylation | LSVSTLPSLREEEEQ CCHHCCCCCCHHHHH | 43.07 | 24719451 | |
| 299 | Phosphorylation | SKFAFLRSPLTLIDL CCCHHHCCCCHHHHH | 26.80 | - | |
| 315 | Phosphorylation | AILPYYITLLVDGAA HHHHHHHHHHHCHHH | 9.64 | - | |
| 327 | Ubiquitination | GAAAGRRKPGAGNSY HHHCCCCCCCCCCCH | 46.58 | 21906983 | |
| 327 (in isoform 1) | Ubiquitination | - | 46.58 | 21906983 | |
| 360 | Phosphorylation | VMRLARHSLGLQTLG HHHHHHHHHHHHHHC | 20.69 | 25332170 | |
| 369 | Phosphorylation | GLQTLGLTARRCTRE HHHHHCHHHHHHHHH | 19.13 | 25332170 | |
| 471 | Ubiquitination | SRSYLELKQEQERVM CCHHHHHHHHHHHHH | 42.27 | 21906983 | |
| 471 (in isoform 1) | Ubiquitination | - | 42.27 | 21906983 | |
| 489 | Ubiquitination | AQFLIKTKSQLSVSQ HHHHHHCCCCCCCCC | 31.07 | 2190698 | |
| 489 (in isoform 1) | Ubiquitination | - | 31.07 | 21906983 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KCNG1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNG1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNG1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCNB1_HUMAN | KCNB1 | physical | 8980147 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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