ERG1_HUMAN - dbPTM
ERG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ERG1_HUMAN
UniProt AC Q14534
Protein Name Squalene monooxygenase
Gene Name SQLE
Organism Homo sapiens (Human).
Sequence Length 574
Subcellular Localization Microsome membrane
Multi-pass membrane protein. Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway..
Protein Sequence MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSGSQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGLGDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAEPNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKVSVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYMVEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGGMTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSATDDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPWITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
90UbiquitinationSPPESENKEQLEARR
CCCCCCCHHHHHHHH		42.67-
105PhosphorylationRRKGTNISETSLIGT
HHCCCCCCCCEEECC		36.5727251275
107PhosphorylationKGTNISETSLIGTAA
CCCCCCCCEEECCHH		23.2627251275
108PhosphorylationGTNISETSLIGTAAC
CCCCCCCEEECCHHC		17.5927251275
148UbiquitinationVLSRDGRKVTVIERD
HHCCCCCEEEEEECC		48.03-
150PhosphorylationSRDGRKVTVIERDLK
CCCCCEEEEEECCCC		20.85-
157UbiquitinationTVIERDLKEPDRIVG
EEEECCCCCCCCCCE		72.06-
204PhosphorylationIHDQESKSEVQIPYP
ECCCCCCCCEECCCC		52.8922210691
210PhosphorylationKSEVQIPYPLSENNQ
CCCEECCCCCCCCCC		20.5922210691
235UbiquitinationRFIMSLRKAAMAEPN
HHHHHHHHHHHCCCC		45.87-
268UbiquitinationMGVQYKDKETGDIKE
EEEEECCCCCCCCCE		53.69-
274UbiquitinationDKETGDIKELHAPLT
CCCCCCCCEECCCEE		59.99-
289PhosphorylationVVADGLFSKFRKSLV
EEECCHHHHHHHHHH		35.6124719451
290UbiquitinationVADGLFSKFRKSLVS
EECCHHHHHHHHHHC		41.6821890473
293UbiquitinationGLFSKFRKSLVSNKV
CHHHHHHHHHHCCCC		51.80-
312UbiquitinationHFVGFLMKNAPQFKA
HHHHHHHHCCCCHHH		52.70-
318UbiquitinationMKNAPQFKANHAELI
HHCCCCHHHCHHEEE		42.93-
363UbiquitinationLREYMVEKIYPQIPD
HHHHHHHHHHCCCCH		35.81-
373UbiquitinationPQIPDHLKEPFLEAT
CCCCHHHCCCHHHCC		60.98-
396PhosphorylationPASFLPPSSVKKRGV
CHHHCCHHHHCCCCE		45.9130387612
397PhosphorylationASFLPPSSVKKRGVL
HHHCCHHHHCCCCEE		43.6730387612
426UbiquitinationGGMTVAFKDIKLWRK
CCCEEEHHHHHHHHH		49.1321890473
433UbiquitinationKDIKLWRKLLKGIPD
HHHHHHHHHHCCCCC		46.73-
436UbiquitinationKLWRKLLKGIPDLYD
HHHHHHHCCCCCCCC		66.29-
451UbiquitinationDAAIFEAKKSFYWAR
CHHHHHHHHHHHHHC		41.58-
4512-HydroxyisobutyrylationDAAIFEAKKSFYWAR
CHHHHHHHHHHHHHC		41.58-
4522-HydroxyisobutyrylationAAIFEAKKSFYWARK
HHHHHHHHHHHHHCC		53.50-
452UbiquitinationAAIFEAKKSFYWARK
HHHHHHHHHHHHHCC		53.50-
532PhosphorylationAVAIYAVYFCFKSEP
HHHHHHHHHHHHCCC		6.1026074081
537PhosphorylationAVYFCFKSEPWITKP
HHHHHHHCCCCCCCH		28.7426074081
542PhosphorylationFKSEPWITKPRALLS
HHCCCCCCCHHHHHC		31.0026074081
543UbiquitinationKSEPWITKPRALLSS
HCCCCCCCHHHHHCC		24.31-
556UbiquitinationSSGAVLYKACSVIFP
CCHHHHHHHHHHHHH		38.46-
559PhosphorylationAVLYKACSVIFPLIY
HHHHHHHHHHHHHHH		24.0928450419
566PhosphorylationSVIFPLIYSEMKYMV
HHHHHHHHHHHHHCC		13.2728450419
567PhosphorylationVIFPLIYSEMKYMVH
HHHHHHHHHHHHCCC		24.9928450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseMARCHF6O60337
PMID:32170014
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ERG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ERG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN641_HUMANZNF641physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01091Butenafine
DB00735Naftifine
DB00857Terbinafine
Regulatory Network of ERG1_HUMAN

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Related Literatures of Post-Translational Modification

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