FOG2_HUMAN - dbPTM
FOG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOG2_HUMAN
UniProt AC Q8WW38
Protein Name Zinc finger protein ZFPM2
Gene Name ZFPM2
Organism Homo sapiens (Human).
Sequence Length 1151
Subcellular Localization Nucleus .
Protein Description Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity)..
Protein Sequence MSRRKQSKPRQIKRPLEDAIEDEEEECPSEETDIISKGDFPLEESFSTEFGPENLSCEEVEYFCNKGDDEGIQETAESDGDTQSEKPGQPGVETDDWDGPGELEVFQKDGERKIQSRQQLPVGTTWGPFPGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDNKNNCIVYSKGGQLWCTTTKAISEGEELIAFVVDFDSRLQAASQMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEENEDSAHQISSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPGASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLPRESDMEHSPSATEDSLQPATDLLTRSELPQSQKAMQTKDASSDTELDKCEKKTQLFLTNQRPEIQPTTNKQSFSYTKIKSEPSSPRLASSPVQPNIGPSFPVGPFLSQFSFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKGATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEALSPNTGQTSINLLNPAAHSADPENPLLQTSCINSSTVLDLIGPNGKGHDKDFSTQTKKLSTSSNNDDKINGKPVDVKNPSVPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLNNPCTSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLTINKCVPVSKCDTTHSSVSCLEMDVPIDLSKKCLSQSERTTTSPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERNSPDVSYERSIIKCEKNGNLKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENRHLFLPQCLYPGAIKKAKGADQLSPYYGIKPSDYISGSLVIHNTDIEQSRNAENESPKGQASSNGCAALKKDSLPLLPKNRGMVIVNGGLKQDERPAANPQQENISQNPQHEDDHKSPSWISENPLAANENVSPGIPSAEEQLSSIAKGVNGSSQAPTSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationDEEEECPSEETDIIS
HCCCCCCCCCCCCCC		60.7724961811
75PhosphorylationDDEGIQETAESDGDT
CCCHHHHHHHCCCCC		21.2526471730
78PhosphorylationGIQETAESDGDTQSE
HHHHHHHCCCCCCCC		44.4230576142
82PhosphorylationTAESDGDTQSEKPGQ
HHHCCCCCCCCCCCC		39.2530576142
84PhosphorylationESDGDTQSEKPGQPG
HCCCCCCCCCCCCCC		50.0830576142
94PhosphorylationPGQPGVETDDWDGPG
CCCCCCCCCCCCCCC		36.5326471730
213PhosphorylationLQAASQMTLTEGMYP
HHHHHHCCCCCCCCH		23.9222210691
226PhosphorylationYPARLLDSIQLLPQQ
CHHHHHHHHCCCHHH		16.5322210691
238PhosphorylationPQQAAMASILPTAIV
HHHHHHHHHCCHHHC		16.1522210691
242PhosphorylationAMASILPTAIVNKDI
HHHHHCCHHHCCCCC		26.1022210691
261PhosphorylationSCGIWYRSERNLQAH
CCCEEEECCCCHHHH		25.80-
308PhosphorylationPQCTKSFSNARALEM
CHHCCCCCHHHHHHH		36.35-
324SumoylationLNSHSGVKMEEFLPP
HHCCCCCCHHHCCCC		44.0823226341
334PhosphorylationEFLPPGASLKCTVCS
HCCCCCCEEEEEEEC		33.9928787133
395PhosphorylationSGKLPRESDMEHSPS
CCCCCCHHCCCCCCC		43.4623917254
400PhosphorylationRESDMEHSPSATEDS
CHHCCCCCCCCCCCC		13.7726852163
402PhosphorylationSDMEHSPSATEDSLQ
HCCCCCCCCCCCCCC		51.3323403867
404PhosphorylationMEHSPSATEDSLQPA
CCCCCCCCCCCCCHH		44.6626852163
407PhosphorylationSPSATEDSLQPATDL
CCCCCCCCCCHHHHH		23.7526852163
433PhosphorylationAMQTKDASSDTELDK
HHHHCCCCCCCCHHH		38.5923312004
434PhosphorylationMQTKDASSDTELDKC
HHHCCCCCCCCHHHH		50.7223312004
436PhosphorylationTKDASSDTELDKCEK
HCCCCCCCCHHHHHH		40.1626852163
444SumoylationELDKCEKKTQLFLTN
CHHHHHHHHHEEECC		21.1428112733
471SumoylationSFSYTKIKSEPSSPR
CCEEEEECCCCCCCC		50.7723226341
472PhosphorylationFSYTKIKSEPSSPRL
CEEEEECCCCCCCCC		59.2130177828
475PhosphorylationTKIKSEPSSPRLASS
EEECCCCCCCCCCCC		49.2630177828
476PhosphorylationKIKSEPSSPRLASSP
EECCCCCCCCCCCCC		25.4230177828
481PhosphorylationPSSPRLASSPVQPNI
CCCCCCCCCCCCCCC		39.5027251275
482PhosphorylationSSPRLASSPVQPNIG
CCCCCCCCCCCCCCC		24.3927251275
532PhosphorylationHRRLRHGSSSYPPVI
HHHHHCCCCCCCCEE		15.2423917254
572PhosphorylationVHKKHYCSSRWQQMA
ECCHHHHHHHHHHHH		18.7728842319
581PhosphorylationRWQQMAKSPEFPSVS
HHHHHHHCCCCCCHH		21.8128355574
586PhosphorylationAKSPEFPSVSEKMPE
HHCCCCCCHHHHCCC		43.5325159151
588PhosphorylationSPEFPSVSEKMPEAL
CCCCCCHHHHCCCHH		35.5225159151
651AcetylationKDFSTQTKKLSTSSN
CCCCCCCCCCCCCCC		41.7324846315
721PhosphorylationHDPPLKRSASNKVPA
CCCCCCCCCCCCCHH		34.1723186163
723PhosphorylationPPLKRSASNKVPAMQ
CCCCCCCCCCCHHHH		38.1323186163
900PhosphorylationKVFPNPESERNSPDV
EECCCCHHHCCCCCC		43.0128355574
904PhosphorylationNPESERNSPDVSYER
CCHHHCCCCCCCHHH		28.7923403867
908PhosphorylationERNSPDVSYERSIIK
HCCCCCCCHHHEEEE		28.7623403867
909PhosphorylationRNSPDVSYERSIIKC
CCCCCCCHHHEEEEE		18.4023403867
912PhosphorylationPDVSYERSIIKCEKN
CCCCHHHEEEEECCC		19.4124719451
915SumoylationSYERSIIKCEKNGNL
CHHHEEEEECCCCCC		34.3723226341
955SumoylationAAQLIATKEENRHLF
HHHHHHCHHHHCCCC		54.7523226341
982PhosphorylationAKGADQLSPYYGIKP
CCCCCCCCCCCCCCH		12.7729116813
990PhosphorylationPYYGIKPSDYISGSL
CCCCCCHHHCCCCCE		37.7418452278
1007PhosphorylationHNTDIEQSRNAENES
ECCCHHHHCCCCCCC		18.0829507054
1014PhosphorylationSRNAENESPKGQASS
HCCCCCCCCCCCCCC		43.4228112733
1031PhosphorylationCAALKKDSLPLLPKN
CCHHCCCCCCCCCCC		40.5422985185
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOG2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GATA1_HUMANGATA1physical
10438528
GATA4_HUMANGATA4physical
18252717
MTA1_HUMANMTA1physical
18067919
MTA2_HUMANMTA2physical
18067919
HDAC1_HUMANHDAC1physical
18067919
HDAC2_HUMANHDAC2physical
18067919
RBBP7_HUMANRBBP7physical
18067919
RBBP4_HUMANRBBP4physical
18067919
MTA3_HUMANMTA3physical
18067919
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
187500Tetralogy of Fallot (TOF)
610187Diaphragmatic hernia 3 (DIH3)
61606746,XY sex reversal 9 (SRXY9)
217095Conotruncal heart malformations (CTHM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOG2_HUMAN

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Related Literatures of Post-Translational Modification

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