RUFY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUFY2_HUMAN
• UniProt AC: Q8WXA3
• Protein Name: RUN and FYVE domain-containing protein 2
• Gene Name: RUFY2
• Organism: Homo sapiens (Human).
• Sequence Length: 606
• Subcellular Localization: Nucleus.
• Protein Sequence: MATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSMYLKNEEDIGNKERNVQIAAILDQKNYVEELNRQLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSCHALLIQRCSSNLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Ubiquitination	FFVVMEHCLKHGLKV HHHHHHHHHHHCCHH	64.91	-
56	Phosphorylation	VMEHCLKHGLKVRKS HHHHHHHHCCHHHHH	54.17	27134283
112	Phosphorylation	ARAWLRLALMQKKMA HHHHHHHHHHHHHHH	22.36	27251275
140	Phosphorylation	SEFYEYHALMMEEEG HHHHHHHHHHHCCCC	16.69	24905233
170	Phosphorylation	NLCVKGEDLDSQVGV CEEECCCCCCCCCCE	6.11	-
187	Ubiquitination	FSMYLKNEEDIGNKE HHHEECCHHHHCCCC	4.88	-
233	Phosphorylation	RVDSLEKSNTKLIEE HHHHHHHHCHHHHHH	3.44	20068231
257	Phosphorylation	KLQEENHQLRSENKL HHHHHHHHHHHCCCE	19.10	27174698
267	Phosphorylation	SENKLILMKTQQHLE HCCCEEEEEHHHCCE	38.49	22468782
268	Phosphorylation	ENKLILMKTQQHLEV CCCEEEEEHHHCCEE	24.27	20068231
270	Phosphorylation	KLILMKTQQHLEVTK CEEEEEHHHCCEEEE	27.54	20068231
271	Phosphorylation	LILMKTQQHLEVTKV EEEEEHHHCCEEEEE	26.26	20068231
274	Phosphorylation	MKTQQHLEVTKVDVE EEHHHCCEEEEECHH	39.01	20068231
278	Phosphorylation	QHLEVTKVDVETELQ HCCEEEEECHHHHHH	35.25	20068231
282	Phosphorylation	VTKVDVETELQTYKH EEEECHHHHHHHHHH	40.12	20068231
284	Phosphorylation	KVDVETELQTYKHSR EECHHHHHHHHHHHH	34.03	22468782
294	Ubiquitination	YKHSRQGLDEMYNEA HHHHHHCHHHHHHHH	44.40	-
318	Phosphorylation	LRQDVENELAVQVSM HHHHHHHHHHHHHHH	21.35	29743597
325 (in isoform 3)	Phosphorylation	-	18.90	27251275
325	Phosphorylation	ELAVQVSMKHEIELA HHHHHHHHHHHHHHH	18.90	29743597
331	Phosphorylation	SMKHEIELAMKLLEK HHHHHHHHHHHHHHH	41.67	-
335	Phosphorylation	EIELAMKLLEKDIHE HHHHHHHHHHHHHHH	47.35	27251275
335 (in isoform 1)	O-linked_Glycosylation	-	47.35	29351928
336	Phosphorylation	IELAMKLLEKDIHEK HHHHHHHHHHHHHHH	8.17	-
339	Phosphorylation	AMKLLEKDIHEKQDT HHHHHHHHHHHHHHH	23.34	28348404
347	Phosphorylation	IHEKQDTLIGLRQQL HHHHHHHHHHHHHHH	14.06	-
352 (in isoform 5)	Phosphorylation	-	47.11	-
354 (in isoform 5)	Phosphorylation	-	7.65	20873877
358 (in isoform 5)	Phosphorylation	-	38.51	20873877
367 (in isoform 5)	Phosphorylation	-	25.30	-
371 (in isoform 5)	Phosphorylation	-	18.89	-
373	Phosphorylation	QKLQGSEDGLKEKNE HHHCCCCCHHHHHHH	12.67	29083192
376 (in isoform 4)	Phosphorylation	-	32.40	-
378 (in isoform 4)	Phosphorylation	-	5.41	20873877
382 (in isoform 4)	Phosphorylation	-	4.99	20873877
391 (in isoform 4)	Phosphorylation	-	53.39	-
395 (in isoform 4)	Phosphorylation	-	20.13	-
414	Phosphorylation	EKAQMEAEDEDEKYL HHHHHHCCHHHHHHH	6.95	26437602
420	Phosphorylation	AEDEDEKYLQECLSK CCHHHHHHHHHHHHC	21.39	25072903
458	Phosphorylation	IEKEWRQTLQEDLQK HHHHHHHHHHHHHHH	12.88	18452278
468	Acetylation	EDLQKEKDALSHLRN HHHHHHHHHHHHHHH	64.68	-
476	Acetylation	ALSHLRNETQQIISL HHHHHHHHHHHHHHH	45.38	-
482	Acetylation	NETQQIISLKKEFLN HHHHHHHHHHHHHHC	55.69	-
487	Acetylation	IISLKKEFLNLQDEN HHHHHHHHHCCCCHH	61.15	-
493	Phosphorylation	EFLNLQDENQQLKKI HHHCCCCHHHHHHHH	42.02	18452278
493 (in isoform 3)	Phosphorylation	-	42.02	27251275
507	Phosphorylation	IYHEQEQALQELGNK HHHHHHHHHHHHHHH	23.10	20068231
531	Phosphorylation	DIKEANKALQGLVWL HHHHHHHHHHHCEEE	35.45	24719451
567	Phosphorylation	HHCRNCGEIFCNACS HHCCCCCCEECCCCC	39.65	-
582	Phosphorylation	DNELPLPSSPKPVRV CCCCCCCCCCCCEEE	48.29	18669648
593	Phosphorylation	PVRVCDSCHALLIQR CEEECCCCHHHHHHH	28.97	29759185
603	Phosphorylation	LLIQRCSSNLP---- HHHHHHHCCCC----	32.59	29759185
617	Phosphorylation	------------------ ------------------	2.64	18669648
617 (in isoform 3)	Phosphorylation	-	2.64	27251275
618 (in isoform 3)	Phosphorylation	-	1.98	24719451
627 (in isoform 3)	Phosphorylation	-	7.09	27251275
631	Phosphorylation	-------------------------------- --------------------------------	67.94	29116813
632	Phosphorylation	--------------------------------- ---------------------------------	34.70	25159151
641	Phosphorylation	------------------------------------------ ------------------------------------------	11.59	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUFY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUFY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUFY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PURB_HUMAN	PURB	physical	26344197
RUFY1_HUMAN	RUFY1	physical	28514442
RUFY3_HUMAN	RUFY3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.