KT3K_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KT3K_HUMAN
• UniProt AC: Q9HA64
• Protein Name: Ketosamine-3-kinase
• Gene Name: FN3KRP
• Organism: Homo sapiens (Human).
• Sequence Length: 309
• Protein Description: Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation..
• Protein Sequence: MEELLRRELGCSSVRATGHSGGGCISQGRSYDTDQGRVFVKVNPKAEARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADLHLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKIPDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWNHFGSGYRGSSLNIMRNLVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MEELLRRELGCSS --CHHHHHHHHCCCC	42.52	-
20	Phosphorylation	SVRATGHSGGGCISQ CCCCCCCCCCCCCCC	40.24	22817900
26	Phosphorylation	HSGGGCISQGRSYDT CCCCCCCCCCCCEEC	30.56	-
41	Ubiquitination	DQGRVFVKVNPKAEA CCCEEEEEECCHHHH	25.48	-
45	Ubiquitination	VFVKVNPKAEARRMF EEEEECCHHHHHHHH	54.37	21890473
58	Phosphorylation	MFEGEMASLTAILKT HHCCCHHHHHHHHHC	25.58	30177828
60	Phosphorylation	EGEMASLTAILKTNT CCCHHHHHHHHHCCC	14.79	30177828
64	Ubiquitination	ASLTAILKTNTVKVP HHHHHHHHCCCCCCC	33.35	21890473
69	Ubiquitination	ILKTNTVKVPKPIKV HHHCCCCCCCCCEEE	51.27	21890473
84	Phosphorylation	LDAPGGGSVLVMEHM EECCCCCEEEEEECC	18.62	-
97	Phosphorylation	HMDMRHLSSHAAKLG CCCHHHHHHHHHHHH	17.60	27135362
98	Phosphorylation	MDMRHLSSHAAKLGA CCHHHHHHHHHHHHH	24.41	27135362
102	Ubiquitination	HLSSHAAKLGAQLAD HHHHHHHHHHHHHHH	48.51	-
115	Ubiquitination	ADLHLDNKKLGEMRL HHCCCCCCHHHCEEH	49.38	21890473
123	Ubiquitination	KLGEMRLKEAGTVGR HHHCEEHHHCCCCCC	34.84	-
127	Phosphorylation	MRLKEAGTVGRGGGQ EEHHHCCCCCCCCCC	27.17	18212344
130	Methylation	KEAGTVGRGGGQEER HHCCCCCCCCCCCCC	35.93	-
194	Phosphorylation	REALQLWSALQLKIP HHHHHHHHHHHCCCC	27.91	24719451
285	Phosphorylation	QLYQLFHYLNHWNHF HHHHHHHHHCCCCCC	11.23	-
294	Phosphorylation	NHWNHFGSGYRGSSL CCCCCCCCCCCCHHH	31.54	25106551
296	Phosphorylation	WNHFGSGYRGSSLNI CCCCCCCCCCHHHHH	17.31	-
300	Phosphorylation	GSGYRGSSLNIMRNL CCCCCCHHHHHHHHH	28.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KT3K_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KT3K_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KT3K_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TRFL_HUMAN	LTF	physical	26186194
LACRT_HUMAN	LACRT	physical	26186194
PIGR_HUMAN	PIGR	physical	26186194
TRFL_HUMAN	LTF	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442
DOHH_HUMAN	DOHH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20, AND MASSSPECTROMETRY.
PubMed: 19369195