LACRT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LACRT_HUMAN
• UniProt AC: Q9GZZ8
• Protein Name: Extracellular glycoprotein lacritin
• Gene Name: LACRT
• Organism: Homo sapiens (Human).
• Sequence Length: 138
• Subcellular Localization: Secreted.
• Protein Description: Modulates secretion by lacrimal acinar cells..
• Protein Sequence: MKFTTLLFLAAVAGALVYAEDASSDSTGADPAQEAGTSKPNEEISGPAEPASPPETTTTAQETSAAAVQGTAKVTSSRQELNPLKSIVEKSILLTEQALAKAGKGMHGGVPGGKQFIENGSEFAQKLLKKFSLLKPWA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	O-linked_Glycosylation	VQGTAKVTSSRQELN HHCCEEECCCCHHHC	21.93	55829599
76	O-linked_Glycosylation	QGTAKVTSSRQELNP HCCEEECCCCHHHCC	26.89	55829603
77	O-linked_Glycosylation	GTAKVTSSRQELNPL CCEEECCCCHHHCCH	28.72	55829607
119	N-linked_Glycosylation	GGKQFIENGSEFAQK CHHHHHHCHHHHHHH	55.25	16740002
121	Phosphorylation	KQFIENGSEFAQKLL HHHHHCHHHHHHHHH	40.91	-
132	Phosphorylation	QKLLKKFSLLKPWA- HHHHHHHCCCCCCC-	41.49	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LACRT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LACRT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LACRT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC1_HUMAN	SDC1	physical	16982797
VTNC_HUMAN	VTN	physical	11419941
FINC_HUMAN	FN1	physical	11419941
NID1_HUMAN	NID1	physical	11419941
A4_HUMAN	APP	physical	21832049
SDC1_HUMAN	SDC1	physical	23504321
TGM2_HUMAN	TGM2	physical	23425695
PLXA2_HUMAN	PLXNA2	physical	28514442
PCYXL_HUMAN	PCYOX1L	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
K319L_HUMAN	KIAA0319L	physical	28514442
NDST2_HUMAN	NDST2	physical	28514442
EMC4_HUMAN	EMC4	physical	28514442
SELN_HUMAN	SEPN1	physical	28514442
ACOX1_HUMAN	ACOX1	physical	28514442
RN114_HUMAN	RNF114	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-linked glycoproteins in human saliva byglycoprotein capture and mass spectrometry.";
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T.,Loo J.A.;
J. Proteome Res. 5:1493-1503(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119, AND MASSSPECTROMETRY.
PubMed: 16740002