dbPTM

ASB13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASB13_HUMAN
UniProt AC	Q8WXK3
Protein Name	Ankyrin repeat and SOCS box protein 13
Gene Name	ASB13
Organism	Homo sapiens (Human).
Sequence Length	278
Subcellular Localization
Protein Description	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence	MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
191	Ubiquitination	TALHHAAKVKNVDLI HHHHHHHHCCCCCHH	55.30	29967540
216	Ubiquitination	YARDNRGKKPSDYTW EEECCCCCCCCCCCC	59.27	-
261	Ubiquitination	TGVRGLEKIAKLNIP CCCCCHHHHHHCCCC	53.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASB13_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASB13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASB13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MARK3_HUMAN	MARK3	physical	16169070
RPC1_HUMAN	POLR3A	physical	24337577
ELOB_HUMAN	TCEB2	physical	24337577
SSBP_HUMAN	SSBP1	physical	24337577
ELOC_HUMAN	TCEB1	physical	24337577
RBX2_HUMAN	RNF7	physical	24337577
TCPQ_HUMAN	CCT8	physical	24337577
CUL5_HUMAN	CUL5	physical	24337577
ZMIZ2_HUMAN	ZMIZ2	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASB13_HUMAN

Related Literatures of Post-Translational Modification