GCM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCM1_HUMAN
• UniProt AC: Q9NP62
• Protein Name: Chorion-specific transcription factor GCMa
• Gene Name: GCM1
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. [PubMed: 10542267]
• Protein Sequence: MEPDDFDSEDKEILSWDINDVKLPQNVKKTDWFQEWPDSYAKHIYSSEDKNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCGRDCLAEEGRKIYLRPAICDKARQKQQRKRCPNCDGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPKPETKLEAEARRAMKKVNTAPSSVSLSLKGSTETRSLPGETQSQGSLPLTWSFQEGVQLPGSYSGHLIANTPQQNSLNDCFSFSKSYGLGGITDLTDQTSTVDPMKLYEKRKLSSSRTYSSGDLLPPSASGVYSDHGDLQAWSKNAALGRNHLADNCYSNYPFPLTSWPCSFSPSQNSSEPFYQQLPLEPPAAKTGCPPLWPNPAGNLYEEKVHVDFNSYVQSPAYHSPQEDPFLFTYASHPHQQYSLPSKSSKWDFEEEMTYLGLDHCNNDMLLNLCPLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	YAKHIYSSEDKNAQR HHHHCCCCCCHHHHH	32.61	21791615
64	O-linked_Glycosylation	SSWAMRNTNNHNSRI HHHHHHHCCCCCHHH	27.34	30379171
69	Phosphorylation	RNTNNHNSRILKKSC HHCCCCCHHHHHHHC	17.10	-
95	Phosphorylation	AEEGRKIYLRPAICD HHCCCEEEECHHHHH	10.33	-
156	Sumoylation	KGEHDHPKPETKLEA CCCCCCCCCHHHHHH	52.66	-
156	Sumoylation	KGEHDHPKPETKLEA CCCCCCCCCHHHHHH	52.66	-
174	Phosphorylation	RAMKKVNTAPSSVSL HHHHHHCCCCCCEEE	42.82	29083192
177	Phosphorylation	KKVNTAPSSVSLSLK HHHCCCCCCEEEEEC	40.69	29083192
178	Phosphorylation	KVNTAPSSVSLSLKG HHCCCCCCEEEEECC	18.05	29083192
180	Phosphorylation	NTAPSSVSLSLKGST CCCCCCEEEEECCCC	17.75	24719451
182	Phosphorylation	APSSVSLSLKGSTET CCCCEEEEECCCCCE	22.11	24719451
237	Phosphorylation	NSLNDCFSFSKSYGL CCHHHHCHHHHHHCC	34.64	24719451
269	Phosphorylation	LYEKRKLSSSRTYSS HHHHCCCCCCCCCCC	29.33	21791615
275	Phosphorylation	LSSSRTYSSGDLLPP CCCCCCCCCCCCCCC	27.51	20855292
322	Phosphorylation	NYPFPLTSWPCSFSP CCCCCCCCCCCCCCC	36.38	19416964
326	Phosphorylation	PLTSWPCSFSPSQNS CCCCCCCCCCCCCCC	25.36	19416964
367	Acetylation	AGNLYEEKVHVDFNS CCCCCEEEEECCHHH	26.21	16166624
402	Phosphorylation	SHPHQQYSLPSKSSK CCCCCCCCCCCCCCC	29.48	29802988
405	Phosphorylation	HQQYSLPSKSSKWDF CCCCCCCCCCCCCCH	50.92	24719451
406	Acetylation	QQYSLPSKSSKWDFE CCCCCCCCCCCCCHH	57.73	16166624
409	Acetylation	SLPSKSSKWDFEEEM CCCCCCCCCCHHHHH	58.85	16166624

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
47	S	Phosphorylation	Kinase	CAMK1	Q14012	GPS
269	S	Phosphorylation	Kinase	PKACA	P17612	PSP
275	S	Phosphorylation	Kinase	PKACA	P17612	PSP
322	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW2	Q9UKT8	PMID:15640526

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC9_HUMAN	UBE2I	physical	17646165
CBP_HUMAN	CREBBP	physical	16166624
CUL1_HUMAN	CUL1	physical	15640526
SKP1_HUMAN	SKP1	physical	15640526
FBXW2_HUMAN	FBXW2	physical	15640526
HDAC1_HUMAN	HDAC1	physical	16528103
HDAC3_HUMAN	HDAC3	physical	16528103
HDAC4_HUMAN	HDAC4	physical	16528103
HDAC5_HUMAN	HDAC5	physical	16528103
DUS23_HUMAN	DUSP23	physical	20855292
CBP_HUMAN	CREBBP	physical	20855292
SENP1_HUMAN	SENP1	physical	21791615

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.