FBXW2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXW2_HUMAN
• UniProt AC: Q9UKT8
• Protein Name: F-box/WD repeat-containing protein 2
• Gene Name: FBXW2
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MERKDFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLLKWLDPQTLLTCCLVSKQWNKVISACTEVWQTACKNLGWQIDDSVQDALHWKKVYLKAILRMKQLEDHEAFETSSLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCAAVKFDEQKLVTGSFDNTVACWEWSSGARTQHFRGHTGAVFSVDYNDELDILVSGSADFTVKVWALSAGTCLNTLTGHTEWVTKVVLQKCKVKSLLHSPGDYILLSADKYEIKIWPIGREINCKCLKTLSVSEDRSICLQPRLHFDGKYIVCSSALGLYQWDFASYDILRVIKTPEIANLALLGFGDIFALLFDNRYLYIMDLRTESLISRWPLPEYRKSKRGSSFLAGEASWLNGLDGHNDTGLVFATSMPDHSIHLVLWKEHG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	TDLQKNETLDHLISL HHCCCCCCHHHHHHH	47.05	24719451
45	Phosphorylation	AVQLRHLSNNLETLL HHHHHHHHHCHHHHH	19.97	26074081
50	Phosphorylation	HLSNNLETLLKRDFL HHHHCHHHHHHHHHH	40.32	26074081
120	Ubiquitination	VQDALHWKKVYLKAI HHHHHHHHHHHHHHH	22.93	-
125	Ubiquitination	HWKKVYLKAILRMKQ HHHHHHHHHHHHHHH	18.72	-
131	Ubiquitination	LKAILRMKQLEDHEA HHHHHHHHHCCCCCC	45.34	-
278	Ubiquitination	VTKVVLQKCKVKSLL HHHHHHHHCCHHHHH	31.68	-
298	Acetylation	YILLSADKYEIKIWP EEEEECCCEEEEEEE	44.49	19608861
313	Ubiquitination	IGREINCKCLKTLSV CCCEEECEEECEEEE	37.81	-
338	Phosphorylation	RLHFDGKYIVCSSAL CCEECCEEEEEECCC	12.24	-
386	Phosphorylation	ALLFDNRYLYIMDLR HHHCCCCEEEEEECC	15.31	29759185
388	Phosphorylation	LFDNRYLYIMDLRTE HCCCCEEEEEECCCC	5.81	29759185
396	Phosphorylation	IMDLRTESLISRWPL EEECCCCHHHHCCCC	30.32	24719451
399	Phosphorylation	LRTESLISRWPLPEY CCCCHHHHCCCCHHH	33.32	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXW2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXW2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXW2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	10531035
SKP1_HUMAN	SKP1	physical	10531035
SKP1_HUMAN	SKP1	physical	22388891
RBX1_HUMAN	RBX1	physical	19398581
CUL1_HUMAN	CUL1	physical	19398581
SKP1_HUMAN	SKP1	physical	19398581
REST_HUMAN	REST	physical	18354482
BTG1_HUMAN	BTG1	physical	22975506
BTG2_HUMAN	BTG2	physical	22975506
SKP1_HUMAN	SKP1	physical	15070733
CUL1_HUMAN	CUL1	physical	14603323
RACK1_HUMAN	GNB2L1	physical	23651062
GCM1_HUMAN	GCM1	physical	23651062
CUL1_HUMAN	CUL1	physical	22268729
EP300_HUMAN	EP300	physical	19297328
CUL1_HUMAN	CUL1	physical	25515538
SKP1_HUMAN	SKP1	physical	26087183
FBW1A_HUMAN	BTRC	physical	28090088
SKP2_HUMAN	SKP2	physical	28090088
CUL1_HUMAN	CUL1	physical	28090088
RBX1_HUMAN	RBX1	physical	28090088

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-298, AND MASS SPECTROMETRY.
PubMed: 19608861