CC186_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC186_HUMAN
• UniProt AC: Q7Z3E2
• Protein Name: Coiled-coil domain-containing protein 186
• Gene Name: CCDC186
• Organism: Homo sapiens (Human).
• Sequence Length: 898
• Protein Sequence: MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSETDHIAS ------CCCCCCCCC		19413330
2	Phosphorylation	------MSETDHIAS ------CCCCCCCCC		27251275
4	Phosphorylation	----MSETDHIASTS ----CCCCCCCCCCC		27251275
19	Phosphorylation	SDKNVGKTPELKEDS CCCCCCCCCCCCCCC		27251275
31	Phosphorylation	EDSCNLFSGNESSKL CCCCCCCCCCCHHHC		17929957
35	Phosphorylation	NLFSGNESSKLENES CCCCCCCHHHCCCHH		17929957
42	Phosphorylation	SSKLENESKLLSLNT HHHCCCHHHCCCCCC		17929957
46	Phosphorylation	ENESKLLSLNTDKTL CCHHHCCCCCCCCCC		22985185
98	Phosphorylation	EQIANFPSGNFAKHI HHHHCCCCCCHHHHH		26657352
103 (in isoform 1)	Ubiquitination	-		21906983
103	Ubiquitination	FPSGNFAKHISKTNE CCCCCHHHHHHCCCH		2190698
130	Phosphorylation	RSSTFPESANEKTYS HHCCCCCCCCCCCCC		30576142
135	Phosphorylation	PESANEKTYSESPYD CCCCCCCCCCCCCCC		30576142
136	Phosphorylation	ESANEKTYSESPYDT CCCCCCCCCCCCCCC		-
139	Phosphorylation	NEKTYSESPYDTDCT CCCCCCCCCCCCHHH		25159151
141	Phosphorylation	KTYSESPYDTDCTKK CCCCCCCCCCHHHHH		25839225
146	Phosphorylation	SPYDTDCTKKFISKI CCCCCHHHHHHHHHH		30576142
155	Phosphorylation	KFISKIKSVSASEDL HHHHHHHCCCCCHHH		23090842
157	Phosphorylation	ISKIKSVSASEDLLE HHHHHCCCCCHHHHH		23090842
159	Phosphorylation	KIKSVSASEDLLEEI HHHCCCCCHHHHHHH		23090842
168	Phosphorylation	DLLEEIESELLSTEF HHHHHHHHHHHCHHH		23090842
172	Phosphorylation	EIESELLSTEFAEHR HHHHHHHCHHHHHCC		23090842
173	Phosphorylation	IESELLSTEFAEHRV HHHHHHCHHHHHCCC		23090842
202	Phosphorylation	EKCVQDKYLQQEHII HHHHHCHHHHHHHHH		-
327	Acetylation	KESLDLRKEKETLEK HHHCHHHHHHHHHHH		19824963
329	Acetylation	SLDLRKEKETLEKKL HCHHHHHHHHHHHHH		19824973
364	Phosphorylation	KGRLHQLYETKEGET HCCHHHHHHCCCCHH		27642862
387	Phosphorylation	KLKEDINSHVIKVKW HHHHHHHHHHHHHHH		23403867
488	Acetylation	IKELEDLKRTFKEGM HHHHHHHHHHHHHHH		20167786
489	Methylation	KELEDLKRTFKEGMD HHHHHHHHHHHHHHH		-
586	Phosphorylation	EGSRKRESELLLFTE CCCCHHHHHHHHHHH		28555341
592	Phosphorylation	ESELLLFTERLTSKN HHHHHHHHHHHHHCH		-
643	Ubiquitination	NLESRLLKEEELRKE CHHHHHHCHHHHHHH		-
710	Phosphorylation	RKLDQVESGSYDKEV HHHHHHHCCCCCCCH		28348404
712	Phosphorylation	LDQVESGSYDKEVSS HHHHHCCCCCCCHHC		29802988
718	Phosphorylation	GSYDKEVSSMGSRSS CCCCCCHHCCCCCCC		22199227
719	Phosphorylation	SYDKEVSSMGSRSSS CCCCCHHCCCCCCCC		22199227
722	Phosphorylation	KEVSSMGSRSSSSGS CCHHCCCCCCCCCCC		25849741
724	Phosphorylation	VSSMGSRSSSSGSLN HHCCCCCCCCCCCCC		24043423
725	Phosphorylation	SSMGSRSSSSGSLNA HCCCCCCCCCCCCCC		24043423
726	Phosphorylation	SMGSRSSSSGSLNAR CCCCCCCCCCCCCCC		24043423
727	Phosphorylation	MGSRSSSSGSLNARS CCCCCCCCCCCCCCC		24043423
729	Phosphorylation	SRSSSSGSLNARSSA CCCCCCCCCCCCCCC		20363803
734	Phosphorylation	SGSLNARSSAEDRSP CCCCCCCCCCCCCCC		30266825
735	Phosphorylation	GSLNARSSAEDRSPE CCCCCCCCCCCCCCC		30266825
740	Phosphorylation	RSSAEDRSPENTGSS CCCCCCCCCCCCCCC		30266825
744	Phosphorylation	EDRSPENTGSSVAVD CCCCCCCCCCCCCCC		30266825
746	Phosphorylation	RSPENTGSSVAVDNF CCCCCCCCCCCCCCC		30266825
747	Phosphorylation	SPENTGSSVAVDNFP CCCCCCCCCCCCCCC		26657352
809	Phosphorylation	SYILREESGTLSSEA HHHHHHCCCCCCCCC		-
849	Phosphorylation	NGLTLELSLEINRKL CCEEEEEEHHHHHHH		-
886	Ubiquitination	TEIERLIKHQHELEQ HHHHHHHHHHHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC186_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC186_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC186_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CC186_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.