TEKT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEKT3_HUMAN
• UniProt AC: Q9BXF9
• Protein Name: Tektin-3
• Gene Name: TEKT3
• Organism: Homo sapiens (Human).
• Sequence Length: 490
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme.
• Protein Description: Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By similarity)..
• Protein Sequence: MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVASNSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRSNLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSYPNTLRLVGFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	O-linked_Glycosylation	-MERVGCTLTTTYAH -CCCCCCEEEECCCC	22.62	-
9	O-linked_Glycosylation	ERVGCTLTTTYAHPR CCCCCEEEECCCCCC	10.03	-
10	O-linked_Glycosylation	RVGCTLTTTYAHPRP CCCCEEEECCCCCCC	22.41	-
41	N-linked_Glycosylation	RDRFPHSNLTHSLSL HHHCCCCCCCCCCCC	46.02	-
86	N-linked_Glycosylation	TMLPFVSNRTTFFTR CCCCCCCCCCCEEEE	39.76	-
103	N-linked_Glycosylation	PDDWYRSNLTNYQES CCHHHHHCCCCCCCC	41.72	-
111	N-linked_Glycosylation	LTNYQESNTSRHNSE CCCCCCCCCCCCCHH	41.12	-
188	Phosphorylation	LERALMETEAPLQVA HHHHHHHCCHHHHHH	24.39	23403867
221	Phosphorylation	EVEAQLLTEVDTILC HHHHHHHHHHHHHHH	42.42	22468782
239	Acetylation	RMKLHLDKAIAQLAA HHHHHHHHHHHHHHH	48.31	25038526
250	Phosphorylation	QLAANRASQHELEKD HHHHHHHHHHHHHHH	28.91	30622161
256	Acetylation	ASQHELEKDLSDKQT HHHHHHHHHCCCCCH	76.28	25038526
261	Acetylation	LEKDLSDKQTAYRID HHHHCCCCCHHHEEC	46.29	25038526
276	N-linked_Glycosylation	DKCHHLRNTSDGVGY CCCCCCCCCCCCCCC	50.74	-
277	Phosphorylation	KCHHLRNTSDGVGYF CCCCCCCCCCCCCCC	23.04	27251275
278	Phosphorylation	CHHLRNTSDGVGYFR CCCCCCCCCCCCCCC	35.60	24719451
299	Phosphorylation	ATVSVPESWAKFTDD CEEECCHHHHHCCCC	26.68	24719451
302	Acetylation	SVPESWAKFTDDNIL ECCHHHHHCCCCHHH	42.40	25038526
344	N-linked_Glycosylation	WNQFNKVNLSFTNRI HHHCCCCCCCHHHHH	31.41	-
346	Phosphorylation	QFNKVNLSFTNRIAE HCCCCCCCHHHHHHH	25.48	-
465	Phosphorylation	DLAVKANSLYIDQEK EEHHHHCEEEECHHH	27.66	29255136
467	Phosphorylation	AVKANSLYIDQEKCM HHHHCEEEECHHHHH	11.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEKT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEKT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEKT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLU_HUMAN	CLUH	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
ZN703_HUMAN	ZNF703	physical	28514442
TYSD1_HUMAN	TYSND1	physical	28514442
PREP_HUMAN	PITRM1	physical	28514442
PRC2A_HUMAN	PRRC2A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.