F1892_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F1892_HUMAN
• UniProt AC: Q15884
• Protein Name: Protein FAM189A2
• Gene Name: FAM189A2
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFATRRSCIDESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQMDQEQGSSFQMSEGSEAAVIPLDLGCTQVTQDGDIPNIPAEENASTSTPSSTLVRPIRSRRALPPLRTRSKSDPVLHPSEERAAPVLSCEAATQTERRLDLAAVTLRRGLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPLQPSTSRAHKLPSRRQPGLLHLQSCGDLHTFTPAGRPRAERRPRRVEAERPHSLIGVIRETVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
123	Phosphorylation	RRSCIDESQISAEEA HHHHCCHHHCCHHHH	29.12	-
273	Phosphorylation	LPPLRTRSKSDPVLH CCCCCCCCCCCCCCC	35.58	20363803
275	Phosphorylation	PLRTRSKSDPVLHPS CCCCCCCCCCCCCCC	48.68	22617229
324	Phosphorylation	ASRCRPRSLIDYKSY HHHCCCCHHHCCHHH	32.15	24719451
330	Phosphorylation	RSLIDYKSYMDTKLL CHHHCCHHHHCHHHH	21.33	22617229
331	Phosphorylation	SLIDYKSYMDTKLLV HHHCCHHHHCHHHHH	8.54	22617229
350	Phosphorylation	EQSSCTMTPDIHELV HHCCCCCCCCHHHHH	10.31	-
440	Phosphorylation	VEAERPHSLIGVIRE CCCCCCCHHHHHHHH	25.10	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F1892_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F1892_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F1892_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG3_HUMAN	BAG3	physical	16189514
CACO2_HUMAN	CALCOCO2	physical	25416956
STAM2_HUMAN	STAM2	physical	25416956
WWP1_HUMAN	WWP1	physical	25416956
WWP2_HUMAN	WWP2	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
UBXN1_HUMAN	UBXN1	physical	25416956
TMPPE_HUMAN	TMPPE	physical	26186194
CXG1_HUMAN	GJC1	physical	26186194
CXA1_HUMAN	GJA1	physical	26186194
CHPT1_HUMAN	CHPT1	physical	26186194
TRI32_HUMAN	TRIM32	physical	26186194
DNJC1_HUMAN	DNAJC1	physical	26186194
ABCA3_HUMAN	ABCA3	physical	26186194
S26A2_HUMAN	SLC26A2	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
T179B_HUMAN	TMEM179B	physical	26186194
CLDN1_HUMAN	CLDND1	physical	26186194
LGR4_HUMAN	LGR4	physical	26186194
PIGA_HUMAN	PIGA	physical	26186194
S27A3_HUMAN	SLC27A3	physical	26186194
S12A9_HUMAN	SLC12A9	physical	26186194
RHBL4_HUMAN	RHBDD1	physical	26186194
ST7_HUMAN	ST7	physical	26186194
FA8A1_HUMAN	FAM8A1	physical	26186194
CUED1_HUMAN	CUEDC1	physical	26186194
PDZD8_HUMAN	PDZD8	physical	26186194
KCNG1_HUMAN	KCNG1	physical	26186194
CAN15_HUMAN	CAPN15	physical	26186194
SIDT2_HUMAN	SIDT2	physical	26186194
CNEP1_HUMAN	CTDNEP1	physical	26186194
DCAKD_HUMAN	DCAKD	physical	26186194
1433G_HUMAN	YWHAG	physical	26186194
1433Z_HUMAN	YWHAZ	physical	26186194
TBC15_HUMAN	TBC1D15	physical	26186194
HECW2_HUMAN	HECW2	physical	26186194
SL9A1_HUMAN	SLC9A1	physical	26186194
WWOX_HUMAN	WWOX	physical	26186194
AGRL1_HUMAN	LPHN1	physical	26186194
TTYH3_HUMAN	TTYH3	physical	26186194
PDE3B_HUMAN	PDE3B	physical	26186194
TBL2_HUMAN	TBL2	physical	26186194
STXB4_HUMAN	STXBP4	physical	26186194
NEDD4_HUMAN	NEDD4	physical	26186194
ITCH_HUMAN	ITCH	physical	26186194
NED4L_HUMAN	NEDD4L	physical	26186194
WWP1_HUMAN	WWP1	physical	26186194
HMDH_HUMAN	HMGCR	physical	26186194
SPTC2_HUMAN	SPTLC2	physical	26186194
GHDC_HUMAN	GHDC	physical	26186194
PLCC_HUMAN	AGPAT3	physical	26186194
RHDF2_HUMAN	RHBDF2	physical	26186194
PCX3_HUMAN	PCNXL3	physical	26186194
S12A6_HUMAN	SLC12A6	physical	26186194
S12A4_HUMAN	SLC12A4	physical	26186194
ACHA5_HUMAN	CHRNA5	physical	26186194
CP51A_HUMAN	CYP51A1	physical	26186194
S12A2_HUMAN	SLC12A2	physical	26186194
TYW1_HUMAN	TYW1	physical	26186194
AN13A_HUMAN	ANKRD13A	physical	26186194
AN13D_HUMAN	ANKRD13D	physical	26186194
GRM1A_HUMAN	GRAMD1A	physical	26186194
SOAT1_HUMAN	SOAT1	physical	26186194
MBRL_HUMAN	TMEM259	physical	26186194
FZD2_HUMAN	FZD2	physical	26186194
HYEP_HUMAN	EPHX1	physical	26186194
KLH20_HUMAN	KLHL20	physical	26186194
UPK3L_HUMAN	UPK3BL	physical	26186194
ANO6_HUMAN	ANO6	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
RHBD3_HUMAN	RHBDD3	physical	26186194
CSCL1_HUMAN	TMEM63A	physical	26186194
HECW2_HUMAN	HECW2	physical	28514442
NED4L_HUMAN	NEDD4L	physical	28514442
NEDD4_HUMAN	NEDD4	physical	28514442
WWOX_HUMAN	WWOX	physical	28514442
RHDF2_HUMAN	RHBDF2	physical	28514442
AN13D_HUMAN	ANKRD13D	physical	28514442
ANO6_HUMAN	ANO6	physical	28514442
PCX3_HUMAN	PCNXL3	physical	28514442
KCNG1_HUMAN	KCNG1	physical	28514442
S12A6_HUMAN	SLC12A6	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442
CAN15_HUMAN	CAPN15	physical	28514442
SIDT2_HUMAN	SIDT2	physical	28514442
F189B_HUMAN	FAM189B	physical	28514442
RHBD3_HUMAN	RHBDD3	physical	28514442
ITCH_HUMAN	ITCH	physical	28514442
S12A4_HUMAN	SLC12A4	physical	28514442
WWP1_HUMAN	WWP1	physical	28514442
AN13A_HUMAN	ANKRD13A	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
FZD2_HUMAN	FZD2	physical	28514442
AGRL1_HUMAN	LPHN1	physical	28514442
KLH20_HUMAN	KLHL20	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
DNJC1_HUMAN	DNAJC1	physical	28514442
CSCL1_HUMAN	TMEM63A	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
LGR4_HUMAN	LGR4	physical	28514442
RHBL4_HUMAN	RHBDD1	physical	28514442
CUED1_HUMAN	CUEDC1	physical	28514442
T179B_HUMAN	TMEM179B	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442
1433B_HUMAN	YWHAB	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
S12A9_HUMAN	SLC12A9	physical	28514442
1433T_HUMAN	YWHAQ	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
TMPPE_HUMAN	TMPPE	physical	28514442
CLDN1_HUMAN	CLDND1	physical	28514442
PLCC_HUMAN	AGPAT3	physical	28514442
TYW1_HUMAN	TYW1	physical	28514442
S26A2_HUMAN	SLC26A2	physical	28514442
1433E_HUMAN	YWHAE	physical	28514442
HYEP_HUMAN	EPHX1	physical	28514442
WWP2_HUMAN	WWP2	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
TBC15_HUMAN	TBC1D15	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.