CSCL1_HUMAN - dbPTM
CSCL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSCL1_HUMAN
UniProt AC O94886
Protein Name CSC1-like protein 1
Gene Name TMEM63A
Organism Homo sapiens (Human).
Sequence Length 807
Subcellular Localization Lysosome membrane
Multi-pass membrane protein .
Protein Description Acts as an osmosensitive calcium-permeable cation channel..
Protein Sequence MMDSPFLELWQSKAVSIREQLGLGDRPNDSYCYNSAKNSTVLQGVTFGGIPTVLLIDVSCFLFLILVFSIIRRRFWDYGRIALVSEADSESRFQRLSSTSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRTTIANLQTDNDLLWLHTIFAVIYLFLTVGFMRHHTQSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRTLINPKPCGQFCCCEVLGCEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKDFNACKCQSLQCKGEPQPSSHSRELYTSKWTVTFAADPEDICWKNLSIQGLRWWLQWLGINFTLFLGLFFLTTPSIILSTMDKFNVTKPIHALNNPIISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVYLPAKLEKGIHFAAVNQALAAPILCLFWLYFFSFLRLGMKAPATLFTFLVLLLTILVCLAHTCFGCFKHLSPLNYKTEEPASDKGSEAEAHMPPPFTPYVPRILNGLASERTALSPQQQQQQTYGAIHNISGTIPGQCLAQSATGSVAAAPQEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
85PhosphorylationYGRIALVSEADSESR
CCCEEEEECCCCHHH		30108239
89PhosphorylationALVSEADSESRFQRL
EEEECCCCHHHHHHH		30108239
91PhosphorylationVSEADSESRFQRLSS
EECCCCHHHHHHHHC		30108239
97PhosphorylationESRFQRLSSTSSSGQ
HHHHHHHHCCCCCCC		26657352
98PhosphorylationSRFQRLSSTSSSGQQ
HHHHHHHCCCCCCCH		26657352
99PhosphorylationRFQRLSSTSSSGQQD
HHHHHHCCCCCCCHH		26657352
100PhosphorylationFQRLSSTSSSGQQDF
HHHHHCCCCCCCHHH		26657352
101PhosphorylationQRLSSTSSSGQQDFE
HHHHCCCCCCCHHHH		22817900
102PhosphorylationRLSSTSSSGQQDFEN
HHHCCCCCCCHHHHH		22817900
141PhosphorylationEDAIHYLSFQRHIIF
CCHHHHHHHHHHHHH		24719451
221UbiquitinationHTQSIKYKEENLVRR
HHHCCCCCHHHHHHH		-
233PhosphorylationVRRTLFITGLPRDAR
HHHHHEHHCCCHHHH		-
241UbiquitinationGLPRDARKETVESHF
CCCHHHHHHHHHHHH		-
274UbiquitinationAKLIYLCKEKKKTEK
HHHHHHHHHCCCCCC		-
282PhosphorylationEKKKTEKSLTYYTNL
HCCCCCCCEEEEEEC		28152594
284PhosphorylationKKTEKSLTYYTNLQV
CCCCCCEEEEEECEE		28152594
285PhosphorylationKTEKSLTYYTNLQVK
CCCCCEEEEEECEEE		28152594
286PhosphorylationTEKSLTYYTNLQVKT
CCCCEEEEEECEEEC		28152594
336PhosphorylationDRLLERITEEERHVQ
HHHHHHHCHHHHHHC		26437602
365UbiquitinationSMATYILKDFNACKC
HHHHHHHHCCCCCCC		-
371UbiquitinationLKDFNACKCQSLQCK
HHCCCCCCCCCCCCC		-
378UbiquitinationKCQSLQCKGEPQPSS
CCCCCCCCCCCCCCC		-
730PhosphorylationLSPLNYKTEEPASDK
CCCCCCCCCCCCCCC		30266825
735PhosphorylationYKTEEPASDKGSEAE
CCCCCCCCCCCCCCH		30266825
739PhosphorylationEPASDKGSEAEAHMP
CCCCCCCCCCHHCCC		30266825
750PhosphorylationAHMPPPFTPYVPRIL
HCCCCCCCCCHHHHH		28857561
752PhosphorylationMPPPFTPYVPRILNG
CCCCCCCCHHHHHHH		23312004
762PhosphorylationRILNGLASERTALSP
HHHHHHHCCCCCCCH		24719451
765PhosphorylationNGLASERTALSPQQQ
HHHHCCCCCCCHHHH		25159151
768PhosphorylationASERTALSPQQQQQQ
HCCCCCCCHHHHHHH		25159151
776PhosphorylationPQQQQQQTYGAIHNI
HHHHHHHHHCCHHCC		28348404
777PhosphorylationQQQQQQTYGAIHNIS
HHHHHHHHCCHHCCC		22817900
784PhosphorylationYGAIHNISGTIPGQC
HCCHHCCCCCCCCCH		22210691
786PhosphorylationAIHNISGTIPGQCLA
CHHCCCCCCCCCHHH		22210691
799PhosphorylationLAQSATGSVAAAPQE
HHHCCCCCCCCCCCC		22210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CSCL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSCL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSCL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AP3S2_HUMANAP3S2physical
28514442
MFS10_HUMANMFSD10physical
28514442
AP3S1_HUMANAP3S1physical
28514442
AP3B1_HUMANAP3B1physical
28514442
PTN1_HUMANPTPN1physical
28514442
LEG3_HUMANLGALS3physical
28514442
YIPF4_HUMANYIPF4physical
28514442
PIGN_HUMANPIGNphysical
28514442
MFSD5_HUMANMFSD5physical
28514442
AT11C_HUMANATP11Cphysical
28514442
AP3D1_HUMANAP3D1physical
28514442
GPHRA_HUMANGPR89Bphysical
28514442
GPHRB_HUMANGPR89Bphysical
28514442
TM242_HUMANTMEM242physical
28514442
SARAF_HUMANSARAFphysical
28514442
ALG5_HUMANALG5physical
28514442
SERC1_HUMANSERINC1physical
28514442
ARL10_HUMANARL10physical
28514442
VPP1_HUMANATP6V0A1physical
28514442
AP3M1_HUMANAP3M1physical
28514442
ZDHC9_HUMANZDHHC9physical
28514442
GHITM_HUMANGHITMphysical
28514442
CISD2_HUMANCISD2physical
28514442
GPC5C_HUMANGPRC5Cphysical
28514442
BI1_HUMANTMBIM6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSCL1_HUMAN

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Related Literatures of Post-Translational Modification

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