MGN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGN2_HUMAN
• UniProt AC: Q96A72
• Protein Name: Protein mago nashi homolog 2
• Gene Name: MAGOHB
• Organism: Homo sapiens (Human).
• Sequence Length: 148
• Subcellular Localization: Nucleus.
• Protein Description: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway..
• Protein Sequence: MAVASDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVASDFYL ------CCCCCCEEE	12.94	22223895
16	Ubiquitination	LRYYVGHKGKFGHEF EEEECCCCCCCCCEE	58.84	-
18	Acetylation	YYVGHKGKFGHEFLE EECCCCCCCCCEEEE	53.64	-
18	Ubiquitination	YYVGHKGKFGHEFLE EECCCCCCCCCEEEE	53.64	21890473
33	Ubiquitination	FEFRPDGKLRYANNS EEECCCCCEEECCCC	36.85	21890473
36	Phosphorylation	RPDGKLRYANNSNYK CCCCCEEECCCCCCC	24.90	-
40	Phosphorylation	KLRYANNSNYKNDVM CEEECCCCCCCCCEE	41.15	27273156
42	Phosphorylation	RYANNSNYKNDVMIR EECCCCCCCCCEEEE	15.81	27155012
43	Ubiquitination	YANNSNYKNDVMIRK ECCCCCCCCCEEEEH	51.42	21890473
53	Phosphorylation	VMIRKEAYVHKSVME EEEEHHHHHCHHHHH	12.27	20049867
56	Ubiquitination	RKEAYVHKSVMEELK EHHHHHCHHHHHHHH	34.40	-
63	Ubiquitination	KSVMEELKRIIDDSE HHHHHHHHHHCCHHH	44.84	-
73	Ubiquitination	IDDSEITKEDDALWP CCHHHCCCCCCCCCC	65.88	21890473
100	Phosphorylation	VIGDEHISFTTSKIG EECCCCCEEECCCCC	20.60	21406692
102	Phosphorylation	GDEHISFTTSKIGSL CCCCCEEECCCCCCE	24.30	21406692
103	Phosphorylation	DEHISFTTSKIGSLI CCCCEEECCCCCCEE	26.47	21406692
104	Phosphorylation	EHISFTTSKIGSLID CCCEEECCCCCCEEE	21.15	21406692
108	Phosphorylation	FTTSKIGSLIDVNQS EECCCCCCEEECCCC	26.14	23401153
115	Phosphorylation	SLIDVNQSKDPEGLR CEEECCCCCCCCHHH	33.55	26074081
116	Ubiquitination	LIDVNQSKDPEGLRV EEECCCCCCCCHHHH	68.49	21906983
116	Acetylation	LIDVNQSKDPEGLRV EEECCCCCCCCHHHH	68.49	37092765
125	Phosphorylation	PEGLRVFYYLVQDLK CCHHHHHHHHHHHHH	7.95	-
132	Ubiquitination	YYLVQDLKCLVFSLI HHHHHHHHHHHHHHH	33.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBM8A_HUMAN	RBM8A	physical	22939629
DX39B_HUMAN	DDX39B	physical	22939629
ZN398_HUMAN	ZNF398	physical	25416956
ZN250_HUMAN	ZNF250	physical	25416956
C102B_HUMAN	CCDC102B	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
RBM8A_HUMAN	RBM8A	physical	26496610
PYM1_HUMAN	WIBG	physical	26496610
EFGM_HUMAN	GFM1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND MASSSPECTROMETRY.
PubMed: 19690332