S15A3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: S15A3_HUMAN
• UniProt AC: Q8IY34
• Protein Name: Solute carrier family 15 member 3
• Gene Name: SLC15A3
• Organism: Homo sapiens (Human).
• Sequence Length: 581
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity)..
• Protein Sequence: MPAPRAREQPRVPGERQPLLPRGARGPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNETVSQQIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQGPASHSRFSRDRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	N-linked_Glycosylation	ANLVLYLNSTNFNWT HEEEEEECCCCCCCC	32.98	UniProtKB CARBOHYD
66	N-linked_Glycosylation	YLNSTNFNWTGEQAT EECCCCCCCCHHHHH	37.15	UniProtKB CARBOHYD
178	N-linked_Glycosylation	AASSVRSNLTSFGAD HHHHHHHHHHCCCHH	36.45	UniProtKB CARBOHYD
223	N-linked_Glycosylation	VVAFIQQNISFLLGY HHHHHHHCHHHHHCC	18.59	UniProtKB CARBOHYD
356	N-linked_Glycosylation	IFPANPANISVALRA EECCCHHHEEEEECC	28.46	UniProtKB CARBOHYD
439	N-linked_Glycosylation	RLHYIHHNETVSQQI HHHHHCCCCCHHHHH	32.26	UniProtKB CARBOHYD
572	Phosphorylation	RASQGPASHSRFSRD HHCCCCCCCCCCCCC	25.73	27251275
574	Phosphorylation	SQGPASHSRFSRDRG CCCCCCCCCCCCCCC	32.31	27251275
577	Phosphorylation	PASHSRFSRDRG--- CCCCCCCCCCCC---	31.96	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of S15A3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of S15A3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of S15A3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMCL1_HUMAN	GMCL1	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.