| UniProt ID | FASTK_HUMAN | |
|---|---|---|
| UniProt AC | Q14296 | |
| Protein Name | Fas-activated serine/threonine kinase | |
| Gene Name | FASTK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 549 | |
| Subcellular Localization | Isoform 4: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. | |
| Protein Description | Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor.; Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.. | |
| Protein Sequence | MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | SMLRVLLSAQTSPAR HHHHHHHHCCCCCCH | 17.73 | 21712546 | |
| 44 | Phosphorylation | RVLLSAQTSPARLSG HHHHHCCCCCCHHCC | 36.07 | 27732954 | |
| 45 | Phosphorylation | VLLSAQTSPARLSGL HHHHCCCCCCHHCCC | 12.41 | 29496963 | |
| 93 | Ubiquitination | QRLLEQAKSPGELLR HHHHHHCCCHHHHHH | 57.80 | - | |
| 94 | Phosphorylation | RLLEQAKSPGELLRW HHHHHCCCHHHHHHH | 40.95 | - | |
| 127 | Phosphorylation | RLGQLLGSRPRPPPV HHHHHHCCCCCCCCC | 38.80 | 22496350 | |
| 402 | Ubiquitination | ARCKYSHKDIVAEGL CCCCCCCHHHHHHHH | 43.12 | - | |
| 417 | Ubiquitination | RQLLGEEKYRQDLTV HHHHCCHHHHCCCCC | 41.24 | - | |
| 497 | Phosphorylation | DGRVLLGSRALRERH CCCCEECHHHHHHHH | 17.85 | 21712546 | |
| 530 | Ubiquitination | QRGLPQLKSYLRQKL HCCHHHHHHHHHHHH | 31.63 | - | |
| 532 | Phosphorylation | GLPQLKSYLRQKLQA CHHHHHHHHHHHHHH | 12.34 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FASTK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FASTK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FASTK_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RBPMS_HUMAN | RBPMS | physical | 16189514 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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