dbPTM

HLX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HLX_HUMAN
UniProt AC	Q14774
Protein Name	H2.0-like homeobox protein
Gene Name	HLX
Organism	Homo sapiens (Human).
Sequence Length	488
Subcellular Localization	Nucleus .
Protein Description	Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)..
Protein Sequence	MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	FSLWSAAYCSSAGPG HHHHHHHHHHCCCCC	7.80	22210691
24	Phosphorylation	WSAAYCSSAGPGGCS HHHHHHHCCCCCCCC	33.41	22210691
91	Phosphorylation	SFQAAARSPLRPTPV HHHHHHCCCCCCCCC	24.45	27732954
96	Phosphorylation	ARSPLRPTPVVAPSE HCCCCCCCCCCCCCC	23.45	27732954
102	Phosphorylation	PTPVVAPSEVPAGFP CCCCCCCCCCCCCCC	41.30	23312004
152	Phosphorylation	GALQPPASGTRVVPN CCCCCCCCCCCCCCC	46.61	24670416
154	Phosphorylation	LQPPASGTRVVPNPH CCCCCCCCCCCCCCC	20.14	24670416
172	Ubiquitination	SAPAPSSKDLKFGID CCCCCCCCCCCCCHH	71.99	22817900
175	Ubiquitination	APSSKDLKFGIDRIL CCCCCCCCCCHHHHH	52.24	21890473
183	Phosphorylation	FGIDRILSAEFDPKV CCHHHHHHCCCCCCC	24.31	28450419
271	Phosphorylation	TKDTMPQTYKRKRSW ECCCCCHHHHCCHHH	25.74	-
272	Phosphorylation	KDTMPQTYKRKRSWS CCCCCHHHHCCHHHH	11.98	-
277	Phosphorylation	QTYKRKRSWSRAVFS HHHHCCHHHHHHHHH	32.22	-
352	Phosphorylation	KEAGEKPSGGAPAAD HHCCCCCCCCCCCCC	62.01	23312004
366	Phosphorylation	DGEQDERSPSRSEGE CCCCCCCCCCCCCCC	25.77	23312004
368	Phosphorylation	EQDERSPSRSEGEAE CCCCCCCCCCCCCCC	50.08	23312004
400	Phosphorylation	RTEGSERSLHQTTVI CCCCCCCCCCEEEEE	26.59	19413330
404	Phosphorylation	SERSLHQTTVIKAPV CCCCCCEEEEEECCC	16.57	19413330
477	Phosphorylation	TASSAPKSPEPAQGA CCCCCCCCCCCCCCC	33.18	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HLX_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HLX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HLX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CE120_HUMAN	CEP120	physical	28514442
TLE2_HUMAN	TLE2	physical	28514442
TLE4_HUMAN	TLE4	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
TLE1_HUMAN	TLE1	physical	28514442
AES_HUMAN	AES	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
SPS1_HUMAN	SEPHS1	physical	28514442
TLE3_HUMAN	TLE3	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
SFR15_HUMAN	SCAF4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HLX_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400; THR-404 ANDSER-477, AND MASS SPECTROMETRY.	19413330 [Abstract]