ARG39_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARG39_HUMAN
• UniProt AC: Q8N4T4
• Protein Name: Rho guanine nucleotide exchange factor 39
• Gene Name: ARHGEF39
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Cell membrane .
• Protein Description: Promotes cell proliferation..
• Protein Sequence: MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MELSCPGSRCP ----CCCCCCCCCCC		21955146
10	Phosphorylation	LSCPGSRCPVQEQRA CCCCCCCCCHHHHHH		32645325
33	Phosphorylation	TARELLETERRYQEQ HHHHHHHHHHHHHHH		-
86 (in isoform 2)	Ubiquitination	-		21906983
110	Phosphorylation	YNQFAANSERSQTTL HHHHHCCCHHHHHHH		25627689
113	Phosphorylation	FAANSERSQTTLQEQ HHCCCHHHHHHHHHH		24275569
122	Ubiquitination	TTLQEQLKKNKGFRR HHHHHHHHHCCCHHH		2190698
122 (in isoform 1)	Ubiquitination	-		21906983
122 (in isoform 3)	Ubiquitination	-		21906983
122 (in isoform 4)	Ubiquitination	-		21906983
200	Ubiquitination	RVHTIGQKQKNDQHL HHHHHCHHHCCHHHH		27667366
232	Ubiquitination	GRWFLRQGWLLVVPP CCEEEECCEEEEECC		22505724
275	Ubiquitination	RSGTFACKALYPMAQ CCCCCHHHHHHHHHH		22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARG39_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARG39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARG39_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIFA_HUMAN	TIFA	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.