ARG39_HUMAN - dbPTM
ARG39_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARG39_HUMAN
UniProt AC Q8N4T4
Protein Name Rho guanine nucleotide exchange factor 39
Gene Name ARHGEF39
Organism Homo sapiens (Human).
Sequence Length 335
Subcellular Localization Cell membrane .
Protein Description Promotes cell proliferation..
Protein Sequence MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MELSCPGSRCP
----CCCCCCCCCCC
21955146
10PhosphorylationLSCPGSRCPVQEQRA
CCCCCCCCCHHHHHH
32645325
33PhosphorylationTARELLETERRYQEQ
HHHHHHHHHHHHHHH
-
86 (in isoform 2)Ubiquitination-21906983
110PhosphorylationYNQFAANSERSQTTL
HHHHHCCCHHHHHHH
25627689
113PhosphorylationFAANSERSQTTLQEQ
HHCCCHHHHHHHHHH
24275569
122UbiquitinationTTLQEQLKKNKGFRR
HHHHHHHHHCCCHHH
2190698
122 (in isoform 1)Ubiquitination-21906983
122 (in isoform 3)Ubiquitination-21906983
122 (in isoform 4)Ubiquitination-21906983
200UbiquitinationRVHTIGQKQKNDQHL
HHHHHCHHHCCHHHH
27667366
232UbiquitinationGRWFLRQGWLLVVPP
CCEEEECCEEEEECC
22505724
275UbiquitinationRSGTFACKALYPMAQ
CCCCCHHHHHHHHHH
22505724

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARG39_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARG39_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARG39_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TIFA_HUMANTIFAphysical
25416956

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARG39_HUMAN

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Related Literatures of Post-Translational Modification

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