dbPTM

TB22B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TB22B_HUMAN
UniProt AC	Q9NU19
Protein Name	TBC1 domain family member 22B
Gene Name	TBC1D22B
Organism	Homo sapiens (Human).
Sequence Length	505
Subcellular Localization
Protein Description	May act as a GTPase-activating protein for Rab family protein(s)..
Protein Sequence	MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAENSKQF ------CCCHHHHHH	24.39	23572552
13	Phosphorylation	SKQFWKRSAKLPGSI HHHHHHHHCCCCCCC	26.48	-
24	Phosphorylation	PGSIQPVYGAQHPPL CCCCCCCCCCCCCCC	17.27	27642862
57	Phosphorylation	PLKNKKASSFHEFAR CCCCCCCHHHHHHHH	42.28	26657352
58	Phosphorylation	LKNKKASSFHEFARN CCCCCCHHHHHHHHC	35.17	25159151
66	Phosphorylation	FHEFARNTSDAWDIG HHHHHHCCCCCCCCC	23.56	28348404
67	Phosphorylation	HEFARNTSDAWDIGD HHHHHCCCCCCCCCC	28.96	28348404
114	Phosphorylation	LRVKPERSQSTTSDV CCCCCCCCCCCCCCC	27.16	21955146
116	Phosphorylation	VKPERSQSTTSDVPA CCCCCCCCCCCCCCC	34.59	23401153
117	Phosphorylation	KPERSQSTTSDVPAN CCCCCCCCCCCCCCC	23.76	21955146
118	Phosphorylation	PERSQSTTSDVPANY CCCCCCCCCCCCCCE	28.33	22115753
119	Phosphorylation	ERSQSTTSDVPANYK CCCCCCCCCCCCCEE	36.38	22115753
125	Phosphorylation	TSDVPANYKVIKSSS CCCCCCCEEEEECCC	14.56	23403867
129	Ubiquitination	PANYKVIKSSSDAQL CCCEEEEECCCCHHH	47.47	29967540
130	Phosphorylation	ANYKVIKSSSDAQLS CCEEEEECCCCHHHH	24.77	30242111
131	Phosphorylation	NYKVIKSSSDAQLSR CEEEEECCCCHHHHC	27.51	30242111
132	Phosphorylation	YKVIKSSSDAQLSRN EEEEECCCCHHHHCC	44.02	28102081
137	Phosphorylation	SSSDAQLSRNSSDTC CCCCHHHHCCCCCCH	19.82	28555341
140	Phosphorylation	DAQLSRNSSDTCLRN CHHHHCCCCCCHHCC	28.60	23403867
141	Phosphorylation	AQLSRNSSDTCLRNP HHHHCCCCCCHHCCH	40.25	23401153
143	Phosphorylation	LSRNSSDTCLRNPLH HHCCCCCCHHCCHHH	18.52	23403867
154	Phosphorylation	NPLHKQQSLPLRPII CHHHCCCCCCCCCCH	29.47	30266825
168	Phosphorylation	IPLVARISDQNASGA HHHHHCCCCCCCCCC	27.82	25002506
178	Sulfoxidation	NASGAPPMTVREKTR CCCCCCCCCHHHHHH	5.42	21406390
219	Phosphorylation	PREVRPITWRLLSGY CCCCCCCCHHHHCCC	13.76	27251275
224	Phosphorylation	PITWRLLSGYLPANT CCCHHHHCCCCCCCH	29.95	28857561
226	Phosphorylation	TWRLLSGYLPANTER CHHHHCCCCCCCHHH	13.21	27251275
231	Phosphorylation	SGYLPANTERRKLTL CCCCCCCHHHHHHHH	32.73	27251275
264	Phosphorylation	NEEHHQDTYRQIHID CHHHHHHHCCEEEEE	17.65	28787133
375	Ubiquitination	FAQPGIQKKVKALEE CCCCCHHHHHHHHHH	58.58	29967540
503	Phosphorylation	FADAPNHYRR----- HCCCCCCCCC-----	18.09	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TB22B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TB22B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TB22B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEX11_HUMAN	TEX11	physical	25416956
TRI54_HUMAN	TRIM54	physical	25416956
PNMA5_HUMAN	PNMA5	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
DEUP1_HUMAN	CCDC67	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
TB22A_HUMAN	TBC1D22A	physical	28514442
CLC4K_HUMAN	CD207	physical	28514442
S1A7A_HUMAN	S100A7A	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
RDHE2_HUMAN	SDR16C5	physical	28514442
ST2B1_HUMAN	SULT2B1	physical	28514442
KLK7_HUMAN	KLK7	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
PEPL_HUMAN	PPL	physical	28514442
PA24E_HUMAN	PLA2G4E	physical	28514442
INVO_HUMAN	IVL	physical	28514442
SPB8_HUMAN	SERPINB8	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
PLBL1_HUMAN	PLBD1	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442
I36RA_HUMAN	IL36RN	physical	28514442
DR9C7_HUMAN	SDR9C7	physical	28514442
TYPH_HUMAN	TYMP	physical	28514442
EPIPL_HUMAN	EPPK1	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
SPB7_HUMAN	SERPINB7	physical	28514442
AACT_HUMAN	SERPINA3	physical	28514442
CH3L2_HUMAN	CHI3L2	physical	28514442
ARSF_HUMAN	ARSF	physical	28514442
ILEU_HUMAN	SERPINB1	physical	28514442
IL1RA_HUMAN	IL1RN	physical	28514442
AK1BA_HUMAN	AKR1B10	physical	28514442
5NT3A_HUMAN	NT5C3A	physical	28514442
STS_HUMAN	STS	physical	28514442
CATL2_HUMAN	CTSV	physical	28514442
S10A7_HUMAN	S100A7	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
NEUR2_HUMAN	NEU2	physical	28514442
S100P_HUMAN	S100P	physical	28514442
CRBG1_HUMAN	AIM1	physical	28514442
CATH_HUMAN	CTSH	physical	28514442
ES8L1_HUMAN	EPS8L1	physical	28514442
SAP3_HUMAN	GM2A	physical	28514442
CAPG_HUMAN	CAPG	physical	28514442
STAT3_HUMAN	STAT3	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
ECM1_HUMAN	ECM1	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442
SBSN_HUMAN	SBSN	physical	28514442
CBPA4_HUMAN	CPA4	physical	28514442
S10A8_HUMAN	S100A8	physical	28514442
ANXA8_HUMAN	ANXA8	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
S10A9_HUMAN	S100A9	physical	28514442
GSDMA_HUMAN	GSDMA	physical	28514442
NAL10_HUMAN	NLRP10	physical	28514442
TGM3_HUMAN	TGM3	physical	28514442
HMOX1_HUMAN	HMOX1	physical	28514442
SPB13_HUMAN	SERPINB13	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
CPNS2_HUMAN	CAPNS2	physical	28514442
CAN1_HUMAN	CAPN1	physical	28514442
ARF6_HUMAN	ARF6	physical	28514442
CASPE_HUMAN	CASP14	physical	28514442
ASAH1_HUMAN	ASAH1	physical	28514442
S10AG_HUMAN	S100A16	physical	28514442
DSG1_HUMAN	DSG1	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442
CYTM_HUMAN	CST6	physical	28514442
CBPM_HUMAN	CPM	physical	28514442
GCP60_HUMAN	ACBD3	physical	28514442
GLNA_HUMAN	GLUL	physical	28514442
ZA2G_HUMAN	AZGP1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TB22B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	19690332 [Abstract]