| UniProt ID | RDHE2_HUMAN | |
|---|---|---|
| UniProt AC | Q8N3Y7 | |
| Protein Name | Epidermal retinol dehydrogenase 2 | |
| Gene Name | SDR16C5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 309 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH.. | |
| Protein Sequence | MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQKKKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | O-linked_Glycosylation | ------MSFNLQSSK ------CCCCCCCCC | 23.89 | 30379171 | |
| 2 | Phosphorylation | ------MSFNLQSSK ------CCCCCCCCC | 23.89 | 20068231 | |
| 7 | O-linked_Glycosylation | -MSFNLQSSKKLFIF -CCCCCCCCCEEEHH | 47.49 | 30379171 | |
| 7 | Phosphorylation | -MSFNLQSSKKLFIF -CCCCCCCCCEEEHH | 47.49 | 20068231 | |
| 8 | Phosphorylation | MSFNLQSSKKLFIFL CCCCCCCCCEEEHHH | 22.35 | 20068231 | |
| 8 | O-linked_Glycosylation | MSFNLQSSKKLFIFL CCCCCCCCCEEEHHH | 22.35 | 30379171 | |
| 18 | Phosphorylation | LFIFLGKSLFSLLEA EEHHHCHHHHHHHHH | 32.61 | 26434776 | |
| 21 | Phosphorylation | FLGKSLFSLLEAMIF HHCHHHHHHHHHHHH | 37.02 | 20068231 | |
| 95 | Phosphorylation | GATRVHAYTCDCSQK CCCEEEEEECCCCCC | 7.94 | 29449344 | |
| 96 | Phosphorylation | ATRVHAYTCDCSQKE CCEEEEEECCCCCCC | 11.58 | 29449344 | |
| 100 | Phosphorylation | HAYTCDCSQKEGVYR EEEECCCCCCCCCCH | 30.91 | 29449344 | |
| 102 | Ubiquitination | YTCDCSQKEGVYRVA EECCCCCCCCCCHHH | 39.89 | - | |
| 106 | Phosphorylation | CSQKEGVYRVADQVK CCCCCCCCHHHHHHC | 15.38 | 29449344 | |
| 114 | Ubiquitination | RVADQVKKEVGDVSI HHHHHHCCHHCCEEE | 59.79 | - | |
| 132 | Ubiquitination | NAGIVTGKKFLDCPD CCCEECCCCCCCCCH | 30.87 | - | |
| 133 | Ubiquitination | AGIVTGKKFLDCPDE CCEECCCCCCCCCHH | 53.13 | - | |
| 145 | Phosphorylation | PDELMEKSFDVNFKA CHHHHHHCCCCCCEE | 17.24 | 29759185 | |
| 156 | Phosphorylation | NFKAHLWTYKAFLPA CCEEEHHHHHHHHHH | 22.85 | 29759185 | |
| 157 | Phosphorylation | FKAHLWTYKAFLPAM CEEEHHHHHHHHHHH | 6.69 | 29759185 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RDHE2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RDHE2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RDHE2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RDHE2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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