| UniProt ID | NAL10_HUMAN | |
|---|---|---|
| UniProt AC | Q86W26 | |
| Protein Name | NACHT, LRR and PYD domains-containing protein 10 | |
| Gene Name | NLRP10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 655 | |
| Subcellular Localization |
Cytoplasm . Cell membrane Peripheral membrane protein . Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. |
|
| Protein Description | Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. [PubMed: 15096476 Displays anti-inflammatory activity] | |
| Protein Sequence | MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQNLFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | KFYLRDMTLSEGQPP HHHHHHCCCCCCCCC | 31.27 | - | |
| 38 | Phosphorylation | YLRDMTLSEGQPPLA HHHHCCCCCCCCCCC | 30.43 | - | |
| 268 | Phosphorylation | KLKKRGLSPKESLLH HHHHCCCCHHHHHHH | 36.43 | 20068231 | |
| 323 | Phosphorylation | SEEERARYFSSYFTD CHHHHHHHHHHHCCC | 13.56 | - | |
| 327 | Phosphorylation | RARYFSSYFTDEKQA HHHHHHHHCCCHHHH | 14.86 | - | |
| 332 | Acetylation | SSYFTDEKQADRAFD HHHCCCHHHHHHHHH | 54.30 | 7664507 | |
| 377 | Phosphorylation | RGKVVLETPRNSTDI CCCEEEECCCCCCCC | 24.32 | 27251275 | |
| 511 | Phosphorylation | QEGNDEMTLTMQFLL HHCCCCEEEEEEHHH | 19.61 | - | |
| 585 | Phosphorylation | GIQMNNVSFKIKHSN HHCCCCEEEEEECCC | 23.97 | 30266825 | |
| 605 | Acetylation | SQNLFSVKSSLSHGP CCCCCHHHHHHCCCC | 32.88 | 7661873 | |
| 609 | Phosphorylation | FSVKSSLSHGPKEEQ CHHHHHHCCCCHHHC | 28.48 | 30576142 | |
| 620 | Phosphorylation | KEEQKCPSVHGQKEG HHHCCCCCCCCCCCC | 35.90 | 20068231 | |
| 639 | Phosphorylation | AGTQKEASTGKGRGT CCCCCCCCCCCCCCC | 38.49 | 20068231 | |
| 640 | Phosphorylation | GTQKEASTGKGRGTE CCCCCCCCCCCCCCC | 50.38 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAL10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAL10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAL10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of NAL10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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