AP5B1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP5B1_HUMAN
• UniProt AC: Q2VPB7
• Protein Name: AP-5 complex subunit beta-1
• Gene Name: AP5B1
• Organism: Homo sapiens (Human).
• Sequence Length: 878
• Protein Description: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport..
• Protein Sequence: MGPLSRDAWAQRLGAFRASPSAFMAGPEGEDLGRDLLSDLRSEKLSEQTKVSLLALSMEYPAQLWPDASAAEVAATSLLDTLVLLPPRPSALRRPLLLAATTALAAGGALGPTSGASCRLLPLLLGLAAGSDLGRGFVPASEQRPLQATACECLRELESCKPGLLGGSLGLLRGLLGQEGPVQPLSLLLALALRNTLVLQSRVGAGLGGLLTDKVSPTGGGPWDWTLVEEGDGRLQPQAPSWPAAEEGEGERSLTAREHSPEEARELRAAVIQLLDTSYLLTPVAQAQLLWLLGWALRGLQGQPPALFKPQLVRLLGTAQLTLLHAMLALKAAFGEALFTAQDEALLLRRLTLAAQHPALPPPTHLFYLHCVLSFPENWPLGPEGEEAAPLLLGPQLCRGLLPSLLHDPMALLARLHLLCLLCAEEEEEEKGQLPSPRHYLEELLAGLRQRAALDGGPRALATLCFQASYLVACCLAGQPTVLTPLIHGLAQLYQARPMLAPHFVDLLDQVDSELREPLKVVLRQVVVSRPGRDEALCWHLQMLAKVADGDAQSATLNFLQAAAAHCTNWDLQQGLLRVCRALLRAGVRGGLVDLLQVLARQLEDPDGRDHARLYYILLAHLAAPKLGVALGPSLAAPALASSLVAENQGFVAALMVQEAPALVRLSLGSHRVKGPLPVLKLQPEALEPIYSLELRFRVEGQLYAPLEAVHVPCLCPGRPARPLLLPLQPRCPAPARLDVHALYTTSTGLTCHAHLPPLFVNFADLFLPFPQPPEGAGLGFFEELWDSCLPEGAESRVWCPLGPQGLEGLVSRHLEPFVVVAQPPTSYCVAIHLPPDSKLLLRLEAALADGVPVALRTDDWAVLPLAGDYLRGLAAAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	DLGRDLLSDLRSEKL HHCHHHHHHHHHHHC	41.73	24719451
44	Ubiquitination	LSDLRSEKLSEQTKV HHHHHHHHCCHHHHH	59.57	27667366
117	Phosphorylation	LGPTSGASCRLLPLL CCCCCHHHHHHHHHH	11.86	-
161	Ubiquitination	LRELESCKPGLLGGS HHHHHCCCCCCHHHH	51.94	21963094
214	Ubiquitination	LGGLLTDKVSPTGGG CCCHHCCCCCCCCCC	39.10	21906983
218	Phosphorylation	LTDKVSPTGGGPWDW HCCCCCCCCCCCCCC	40.74	28464451
241	Phosphorylation	RLQPQAPSWPAAEEG CCCCCCCCCCCCCCC	49.02	27251275
252	Ubiquitination	AEEGEGERSLTAREH CCCCCCCCCCCCCCC	48.07	21890473
252	Ubiquitination	AEEGEGERSLTAREH CCCCCCCCCCCCCCC	48.07	21890473
253	Phosphorylation	EEGEGERSLTAREHS CCCCCCCCCCCCCCC	26.27	27251275
255	Phosphorylation	GEGERSLTAREHSPE CCCCCCCCCCCCCHH	25.56	27251275
309	Ubiquitination	GQPPALFKPQLVRLL CCCCHHHHHHHHHHH	32.48	27667366
431	Ubiquitination	AEEEEEEKGQLPSPR HCHHHHHCCCCCCHH	56.06	21890473
436	Phosphorylation	EEKGQLPSPRHYLEE HHCCCCCCHHHHHHH	43.06	23403867
617	Ubiquitination	DHARLYYILLAHLAA CHHHHHHHHHHHHHH	1.28	21890473
617	Ubiquitination	DHARLYYILLAHLAA CHHHHHHHHHHHHHH	1.28	21890473
624	Ubiquitination	ILLAHLAAPKLGVAL HHHHHHHHCCCCCCC	14.23	21890473
624	Ubiquitination	ILLAHLAAPKLGVAL HHHHHHHHCCCCCCC	14.23	21890473
674	Ubiquitination	SLGSHRVKGPLPVLK CCCCCCCCCCCCEEE	55.56	21906983
681	Ubiquitination	KGPLPVLKLQPEALE CCCCCEEECCHHHHC	45.36	21906983
692	Phosphorylation	EALEPIYSLELRFRV HHHCCEEEEEEEEEE	18.98	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP5B1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP5B1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP5B1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNRG_HUMAN	KCNRG	physical	16189514

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.