ELOA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELOA2_HUMAN
• UniProt AC: Q8IYF1
• Protein Name: Elongin-A2
• Gene Name: ELOA2 {ECO:0000312|HGNC:HGNC:30771}
• Organism: Homo sapiens (Human).
• Sequence Length: 753
• Subcellular Localization: Nucleus .
• Protein Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)..
• Protein Sequence: MAAGSTTLHAVEKLQVRLATKTEPKKLEKYLQKLSALPMTADILAETGIRKTVKRLRKHQHVGDFARDLAARWKKLVLVDRNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRMPEGPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHSPTLIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHSHSNKKRPSLDGRDPGNGTHGLSPEEKEQLSNDRETQEGKPPTAHLDRTSVSSLSEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGTRESWDSAKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPLSDSDSMTSQAKPEALSSPKFREEAAFPGRRVNAKMPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDAPEQRLRVMTTNIRSARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEIKPASKPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMAKAIRDYKRRFSRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Acetylation	LQVRLATKTEPKKLE HHHHHHCCCCHHHHH	45.33	-
26	"N6,N6-dimethyllysine"	ATKTEPKKLEKYLQK HCCCCHHHHHHHHHH	73.01	-
26	Methylation	ATKTEPKKLEKYLQK HCCCCHHHHHHHHHH	73.01	-
270	Phosphorylation	PRMPSWASARDRQPS CCCCCHHHHCCCCCC	19.99	-
386	Phosphorylation	PTLSCEKYLTYDQLR CCCCHHHCCCHHHHH	5.08	28102081
388	Phosphorylation	LSCEKYLTYDQLRKQ CCHHHCCCHHHHHHH	23.20	28102081
389	Phosphorylation	SCEKYLTYDQLRKQK CHHHCCCHHHHHHHH	10.09	28102081
480	Phosphorylation	NYDPLSDSDSMTSQA CCCCCCCCCCCCCCC	28.36	21601212
603	Phosphorylation	EKPQENKTWREQYLR HCCCCCCCHHHHHHC	41.14	26074081
608	Phosphorylation	NKTWREQYLRLPDAP CCCHHHHHHCCCCCH	6.77	26074081
628	Phosphorylation	VMTTNIRSARGNNPN HHHHHHHHHCCCCCC	20.65	23403867
676	Phosphorylation	NGEIKPASKPAGSSH CCCCCCCCCCCCCCC	47.93	-
699	Phosphorylation	GGGRDSSSSILRWLP CCCCCCHHHHHHHCC	25.91	-
700	Phosphorylation	GGRDSSSSILRWLPE CCCCCHHHHHHHCCH	27.82	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELOA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELOA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELOA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KXDL1_HUMAN	KXD1	physical	16189514
SOLH2_HUMAN	SOHLH2	physical	16189514
CEP70_HUMAN	CEP70	physical	16189514
KR412_HUMAN	KRTAP4-12	physical	16189514
ELOB_HUMAN	TCEB2	physical	10692460
ELOC_HUMAN	TCEB1	physical	10692460
ZCH10_HUMAN	ZCCHC10	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.