SOLH2_HUMAN - dbPTM
SOLH2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOLH2_HUMAN
UniProt AC Q9NX45
Protein Name Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
Gene Name SOHLH2
Organism Homo sapiens (Human).
Sequence Length 425
Subcellular Localization Nucleus . Cytoplasm . Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression.
Protein Description Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity)..
Protein Sequence MASSIICQEHCQISGQAKIDILLVGDVTVGYLADTVQKLFANIAEVTITISDTKEAAALLDDCIFNMVLLKVPSSLSAEELEAIKLIRFGKKKNTHSLFVFIIPENFKGCISGHGMDIALTEPLTMEKMSNVVKYWTTCPSNTVKTENATGPEELGLPLQRSYSEHLGYFPTDLFACSESLRNGNGLELNASLSEFEKNKKISLLHSSKEKLRRERIKYCCEQLRTLLPYVKGRKNDAASVLEATVDYVKYIREKISPAVMAQITEALQSNMRFCKKQQTPIELSLPGTVMAQRENSVMSTYSPERGLQFLTNTCWNGCSTPDAESSLDEAVRVPSSSASENAIGDPYKTHISSAALSLNSLHTVRYYSKVTPSYDATAVTNQNISIHLPSAMPPVSKLLPRHCTSGLGQTCTTHPNCLQQFWAY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 3)Phosphorylation-22.2929083192
7 (in isoform 3)Phosphorylation-3.5629083192
10 (in isoform 3)Phosphorylation-5.2729083192
35PhosphorylationTVGYLADTVQKLFAN
EHHHHHHHHHHHHHH		21.16-
85UbiquitinationAEELEAIKLIRFGKK
HHHHHHHHHHCCCCC		44.9321963094
128UbiquitinationTEPLTMEKMSNVVKY
CCCCCHHHHHCCHHH		36.4821963094
130PhosphorylationPLTMEKMSNVVKYWT
CCCHHHHHCCHHHHC		37.2224719451
134UbiquitinationEKMSNVVKYWTTCPS
HHHHCCHHHHCCCCC		30.6821963094
137PhosphorylationSNVVKYWTTCPSNTV
HCCHHHHCCCCCCCE		18.5429116813
138PhosphorylationNVVKYWTTCPSNTVK
CCHHHHCCCCCCCEE		14.3129116813
141PhosphorylationKYWTTCPSNTVKTEN
HHHCCCCCCCEECCC		47.4824719451
143PhosphorylationWTTCPSNTVKTENAT
HCCCCCCCEECCCCC		27.9324719451
145UbiquitinationTCPSNTVKTENATGP
CCCCCCEECCCCCCH		48.3521963094
162UbiquitinationLGLPLQRSYSEHLGY
HCCCCCCHHHHHCCC		21.7621963094
198UbiquitinationASLSEFEKNKKISLL
CCHHHHHHHHCHHHH		78.4022817900
200UbiquitinationLSEFEKNKKISLLHS
HHHHHHHHCHHHHCC		63.6521963094
201UbiquitinationSEFEKNKKISLLHSS
HHHHHHHCHHHHCCC		47.0922817900
205UbiquitinationKNKKISLLHSSKEKL
HHHCHHHHCCCHHHH		2.6921963094
211UbiquitinationLLHSSKEKLRRERIK
HHCCCHHHHHHHHHH		51.5421963094
222UbiquitinationERIKYCCEQLRTLLP
HHHHHHHHHHHHHHH		49.4421963094
232UbiquitinationRTLLPYVKGRKNDAA
HHHHHHHCCCCCCHH		47.3421963094
235UbiquitinationLPYVKGRKNDAASVL
HHHHCCCCCCHHHHH		68.7722817900
245PhosphorylationAASVLEATVDYVKYI
HHHHHHHHHHHHHHH		12.4425690035
250UbiquitinationEATVDYVKYIREKIS
HHHHHHHHHHHHHCC		28.8221963094
255UbiquitinationYVKYIREKISPAVMA
HHHHHHHHCCHHHHH		38.3422817900
275UbiquitinationLQSNMRFCKKQQTPI
HHHCCHHHHCCCCCE		3.6722817900
276UbiquitinationQSNMRFCKKQQTPIE
HHCCHHHHCCCCCEE		51.4022817900
277UbiquitinationSNMRFCKKQQTPIEL
HCCHHHHCCCCCEEE		49.1421963094
278UbiquitinationNMRFCKKQQTPIELS
CCHHHHCCCCCEEEE		37.5622817900
302PhosphorylationENSVMSTYSPERGLQ
CCCCCCCCCCHHHHH		18.2122817900
303PhosphorylationNSVMSTYSPERGLQF
CCCCCCCCCHHHHHH		22.0024719451
309UbiquitinationYSPERGLQFLTNTCW
CCCHHHHHHHHCCCC		33.8421963094
312UbiquitinationERGLQFLTNTCWNGC
HHHHHHHHCCCCCCC		29.7522817900
327UbiquitinationSTPDAESSLDEAVRV
CCCCHHCCHHHHHCC		31.2021963094
332UbiquitinationESSLDEAVRVPSSSA
HCCHHHHHCCCCCCC		6.2822817900
353UbiquitinationDPYKTHISSAALSLN
CCCCCCHHHHHHHCC		13.3022817900
354PhosphorylationPYKTHISSAALSLNS
CCCCCHHHHHHHCCC		19.56-
354UbiquitinationPYKTHISSAALSLNS
CCCCCHHHHHHHCCC		19.5621963094
361PhosphorylationSAALSLNSLHTVRYY
HHHHHCCCCCHHEEE		27.16-
364PhosphorylationLSLNSLHTVRYYSKV
HHCCCCCHHEEEECC		16.39-
369PhosphorylationLHTVRYYSKVTPSYD
CCHHEEEECCCCCCC		16.2428787133
370UbiquitinationHTVRYYSKVTPSYDA
CHHEEEECCCCCCCC		33.7221963094
374PhosphorylationYYSKVTPSYDATAVT
EEECCCCCCCCEEEE		26.69-
375PhosphorylationYSKVTPSYDATAVTN
EECCCCCCCCEEEEC		15.71-
378PhosphorylationVTPSYDATAVTNQNI
CCCCCCCEEEECCCE		20.82-
381PhosphorylationSYDATAVTNQNISIH
CCCCEEEECCCEEEE		28.7328787133
398UbiquitinationSAMPPVSKLLPRHCT
CCCCCHHHHCCCCCC		55.0321963094
447Ubiquitination-----------------------------
-----------------------------		21963094
475Ubiquitination---------------------------------------------------------
---------------------------------------------------------		21963094
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SOLH2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOLH2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOLH2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SOLH2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOLH2_HUMAN

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Related Literatures of Post-Translational Modification

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