BCL6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCL6B_HUMAN
• UniProt AC: Q8N143
• Protein Name: B-cell CLL/lymphoma 6 member B protein
• Gene Name: BCL6B
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Nucleus.
• Protein Description: Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B-cell development..
• Protein Sequence: MGSPAAPEGALGYVREFTRHSSDVLGNLNELRLRGILTDVTLLVGGQPLRAHKAVLIACSGFFYSIFRGRAGVGVDVLSLPGGPEARGFAPLLDFMYTSRLRLSPATAPAVLAAATYLQMEHVVQACHRFIQASYEPLGISLRPLEAEPPTPPTAPPPGSPRRSEGHPDPPTESRSCSQGPPSPASPDPKACNWKKYKYIVLNSQASQAGSLVGERSSGQPCPQARLPSGDEASSSSSSSSSSSEEGPIPGPQSRLSPTAATVQFKCGAPASTPYLLTSQAQDTSGSPSERARPLPGSEFFSCQNCEAVAGCSSGLDSLVPGDEDKPYKCQLCRSSFRYKGNLASHRTVHTGEKPYHCSICGARFNRPANLKTHSRIHSGEKPYKCETCGSRFVQVAHLRAHVLIHTGEKPYPCPTCGTRFRHLQTLKSHVRIHTGEKPYHCDPCGLHFRHKSQLRLHLRQKHGAATNTKVHYHILGGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSPAAPEGA -----CCCCCCCCCH	15.29	27251275
79	Phosphorylation	GVGVDVLSLPGGPEA CCCCEEEECCCCHHH	32.16	26437602
141	Phosphorylation	SYEPLGISLRPLEAE HCCCCCCCCEECCCC	19.27	22210691
151	Phosphorylation	PLEAEPPTPPTAPPP ECCCCCCCCCCCCCC	53.25	22210691
160	Phosphorylation	PTAPPPGSPRRSEGH CCCCCCCCCCCCCCC	22.47	22210691
172	Phosphorylation	EGHPDPPTESRSCSQ CCCCCCCCCCCCCCC	52.56	-
174	Phosphorylation	HPDPPTESRSCSQGP CCCCCCCCCCCCCCC	31.78	-
183	Phosphorylation	SCSQGPPSPASPDPK CCCCCCCCCCCCCCC	35.91	23403867
186	Phosphorylation	QGPPSPASPDPKACN CCCCCCCCCCCCCCC	32.97	23403867
236	Phosphorylation	SGDEASSSSSSSSSS CCCCCCCCCCCCCCC	31.57	-
237	Phosphorylation	GDEASSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
238	Phosphorylation	DEASSSSSSSSSSSE CCCCCCCCCCCCCCC	35.87	-
239	Phosphorylation	EASSSSSSSSSSSEE CCCCCCCCCCCCCCC	35.87	-
257	Phosphorylation	PGPQSRLSPTAATVQ CCCCCCCCCCEEEEE	21.06	23403867
258	Phosphorylation	GPQSRLSPTAATVQF CCCCCCCCCEEEEEE	30.56	27251275
259	Phosphorylation	PQSRLSPTAATVQFK CCCCCCCCEEEEEEE	26.08	23403867
336	Phosphorylation	KCQLCRSSFRYKGNL CCEECCCCCEECCCC	8.39	17081983
379	Phosphorylation	KTHSRIHSGEKPYKC CCCCCCCCCCCCEEC	46.40	29496963
407	Phosphorylation	RAHVLIHTGEKPYPC EEEEEEECCCCCCCC	39.79	-
435	Phosphorylation	KSHVRIHTGEKPYHC HHCEEEECCCCCCCC	44.67	28111955

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCL6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCL6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCL6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL6_HUMAN	BCL6	physical	12659862
SIN3A_HUMAN	SIN3A	physical	12659862
HDAC1_HUMAN	HDAC1	physical	12659862
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
ST4A1_HUMAN	SULT4A1	physical	26186194
ST4A1_HUMAN	SULT4A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.