dbPTM

HDA11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HDA11_HUMAN
UniProt AC	Q96DB2
Protein Name	Histone deacetylase 11
Gene Name	HDAC11
Organism	Homo sapiens (Human).
Sequence Length	347
Subcellular Localization	Nucleus. Predominantly nuclear.
Protein Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes..
Protein Sequence	MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLHTTQLYQHV ----CCCCCCCCCCC	16.57	28634298
5	Phosphorylation	---MLHTTQLYQHVP ---CCCCCCCCCCCC	13.06	24043423
8	Phosphorylation	MLHTTQLYQHVPETR CCCCCCCCCCCCCCC	6.17	28634298
14	Phosphorylation	LYQHVPETRWPIVYS CCCCCCCCCCCEEEE	31.78	24043423
50	Ubiquitination	GKVINFLKEEKLLSD HHHHHHHCHHCCCCC	60.74	-
56	Phosphorylation	LKEEKLLSDSMLVEA HCHHCCCCCCCEEEH	37.77	25693802
56 (in isoform 2)	Ubiquitination	-	37.77	-
58	Phosphorylation	EEKLLSDSMLVEARE HHCCCCCCCEEEHHH	15.61	30622161
67	Phosphorylation	LVEAREASEEDLLVV EEEHHHCCHHHEEEE	36.44	23312004
76	Phosphorylation	EDLLVVHTRRYLNEL HHEEEEEHHHHHHHC	12.77	23312004
199	Phosphorylation	FMDDKRVYIMDVYNR CCCCCCEEEEECCCC	8.44	21394647
229	Phosphorylation	KVELEWGTEDDEYLD HCEEECCCCCHHHHH	37.00	22210691
234	Phosphorylation	WGTEDDEYLDKVERN CCCCCHHHHHHHHHH	27.48	22210691
280	Ubiquitination	ISPAGIVKRDELVFR ECCCCEECHHHHHHH	52.81	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HDA11_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HDA11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HDA11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC6_HUMAN	HDAC6	physical	11948178
CDT1_HUMAN	CDT1	physical	20980834
GEMI_HUMAN	GMNN	physical	20980834
SMN_HUMAN	SMN1	physical	23752268
DDX20_HUMAN	DDX20	physical	23752268
GEMI4_HUMAN	GEMIN4	physical	23752268
DICER_HUMAN	DICER1	physical	23752268
ADNP_HUMAN	ADNP	physical	23752268
AKAP8_HUMAN	AKAP8	physical	23752268
AKP8L_HUMAN	AKAP8L	physical	23752268
ADAS_HUMAN	AGPS	physical	23752268
AIFM1_HUMAN	AIFM1	physical	23752268
ACINU_HUMAN	ACIN1	physical	23752268
ATAD2_HUMAN	ATAD2	physical	23752268
WRIP1_HUMAN	WRNIP1	physical	23752268
ATG2B_HUMAN	ATG2B	physical	23752268
BAG2_HUMAN	BAG2	physical	23752268
BCLF1_HUMAN	BCLAF1	physical	23752268
PYR1_HUMAN	CAD	physical	23752268
CALU_HUMAN	CALU	physical	23752268
CPT1A_HUMAN	CPT1A	physical	23752268
CLPB_HUMAN	CLPB	physical	23752268
CEBPZ_HUMAN	CEBPZ	physical	23752268
UTP4_HUMAN	CIRH1A	physical	23752268
STAG1_HUMAN	STAG1	physical	23752268
BDH_HUMAN	BDH1	physical	23752268
TDIF2_HUMAN	DNTTIP2	physical	23752268
MSH6_HUMAN	MSH6	physical	23752268
YBOX3_HUMAN	YBX3	physical	23752268
IKZF1_HUMAN	IKZF1	physical	23752268
PRKDC_HUMAN	PRKDC	physical	23752268
RPB1_HUMAN	POLR2A	physical	23752268
RPB2_HUMAN	POLR2B	physical	23752268
DNJA1_HUMAN	DNAJA1	physical	23752268
DNJA2_HUMAN	DNAJA2	physical	23752268
DNJA3_HUMAN	DNAJA3	physical	23752268
DJB11_HUMAN	DNAJB11	physical	23752268
DNJB2_HUMAN	DNAJB2	physical	23752268
DNJB6_HUMAN	DNAJB6	physical	23752268
HUWE1_HUMAN	HUWE1	physical	23752268
UBR5_HUMAN	UBR5	physical	23752268
ERLN2_HUMAN	ERLIN2	physical	23752268
DHB12_HUMAN	HSD17B12	physical	23752268
ETV5_HUMAN	ETV5	physical	23752268
PAXB1_HUMAN	PAXBP1	physical	23752268
GCFC2_HUMAN	GCFC2	physical	23752268
GEMI2_HUMAN	GEMIN2	physical	23752268
DKC1_HUMAN	DKC1	physical	23752268
HEAT1_HUMAN	HEATR1	physical	23752268
HHIP_HUMAN	HHIP	physical	23752268
H1X_HUMAN	H1FX	physical	23752268
H31_HUMAN	HIST1H3A	physical	23752268
HJURP_HUMAN	HJURP	physical	23752268
IF2B3_HUMAN	IGF2BP3	physical	23752268
LAP2A_HUMAN	TMPO	physical	23752268
LAP2B_HUMAN	TMPO	physical	23752268
KDM1A_HUMAN	KDM1A	physical	23752268
MCCB_HUMAN	MCCC2	physical	23752268
MDN1_HUMAN	MDN1	physical	23752268
MLF2_HUMAN	MLF2	physical	23752268
NDUAA_HUMAN	NDUFA10	physical	23752268
SYNE2_HUMAN	SYNE2	physical	23752268
NU133_HUMAN	NUP133	physical	23752268
NU153_HUMAN	NUP153	physical	23752268
NUP85_HUMAN	NUP85	physical	23752268
NUP93_HUMAN	NUP93	physical	23752268
NUP98_HUMAN	NUP98	physical	23752268
NOP56_HUMAN	NOP56	physical	23752268
PESC_HUMAN	PES1	physical	23752268
PHIP_HUMAN	PHIP	physical	23752268
PININ_HUMAN	PNN	physical	23752268
WDR33_HUMAN	WDR33	physical	23752268
PRP6_HUMAN	PRPF6	physical	23752268
RBM22_HUMAN	RBM22	physical	23752268
SYF1_HUMAN	XAB2	physical	23752268
DDX27_HUMAN	DDX27	physical	23752268
MYCB2_HUMAN	MYCBP2	physical	23752268
EBP2_HUMAN	EBNA1BP2	physical	23752268
PML_HUMAN	PML	physical	23752268
RED_HUMAN	IK	physical	23752268
RRP5_HUMAN	PDCD11	physical	23752268
SON_HUMAN	SON	physical	23752268
SC16A_HUMAN	SEC16A	physical	23752268
NOP2_HUMAN	NOP2	physical	23752268
RCOR2_HUMAN	RCOR2	physical	23752268
RCN1_HUMAN	RCN1	physical	23752268
RCN2_HUMAN	RCN2	physical	23752268
RB_HUMAN	RB1	physical	23752268
RN219_HUMAN	RNF219	physical	23752268
RB12B_HUMAN	RBM12B	physical	23752268
RBM14_HUMAN	RBM14	physical	23752268
RBM28_HUMAN	RBM28	physical	23752268
RBM34_HUMAN	RBM34	physical	23752268
RRP12_HUMAN	RRP12	physical	23752268
RUNX1_HUMAN	RUNX1	physical	23752268
AT2A3_HUMAN	ATP2A3	physical	23752268
SRRM2_HUMAN	SRRM2	physical	23752268
PP6R1_HUMAN	PPP6R1	physical	23752268
PP6R3_HUMAN	PPP6R3	physical	23752268
SNW1_HUMAN	SNW1	physical	23752268
S2542_HUMAN	SLC25A42	physical	23752268
SF3A1_HUMAN	SF3A1	physical	23752268
SF3B2_HUMAN	SF3B2	physical	23752268
SMC1A_HUMAN	SMC1A	physical	23752268
SMC3_HUMAN	SMC3	physical	23752268
SMC4_HUMAN	SMC4	physical	23752268
SGT1_HUMAN	SUGT1	physical	23752268
SSF1_HUMAN	PPAN	physical	23752268
TCPD_HUMAN	CCT4	physical	23752268
TCPG_HUMAN	CCT3	physical	23752268
RIF1_HUMAN	RIF1	physical	23752268
TTC27_HUMAN	TTC27	physical	23752268
TR150_HUMAN	THRAP3	physical	23752268
TTF2_HUMAN	TTF2	physical	23752268
GCN1_HUMAN	GCN1L1	physical	23752268
TFP11_HUMAN	TFIP11	physical	23752268
BAZ1B_HUMAN	BAZ1B	physical	23752268
UT14A_HUMAN	UTP14A	physical	23752268
UTP18_HUMAN	UTP18	physical	23752268
UTP6_HUMAN	UTP6	physical	23752268
MAIP1_HUMAN	C2orf47	physical	23752268
WDR36_HUMAN	WDR36	physical	23752268
WDR74_HUMAN	WDR74	physical	23752268
YBOX2_HUMAN	YBX2	physical	23752268
YLPM1_HUMAN	YLPM1	physical	23752268
ZMYM2_HUMAN	ZMYM2	physical	23752268
ZN326_HUMAN	ZNF326	physical	23752268
ZFR_HUMAN	ZFR	physical	23752268
PAXB1_HUMAN	PAXBP1	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
GCFC2_HUMAN	GCFC2	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
OSBL3_HUMAN	OSBPL3	physical	28514442
WIPI4_HUMAN	WDR45	physical	28514442
DCAM_HUMAN	AMD1	physical	28514442
CP062_HUMAN	C16orf62	physical	28514442
TCPB_HUMAN	CCT2	physical	28514442
MTMR3_HUMAN	MTMR3	physical	28514442
ADDG_HUMAN	ADD3	physical	28514442
CACO2_HUMAN	CALCOCO2	physical	28514442
CLU_HUMAN	CLUH	physical	28514442
TCPZ_HUMAN	CCT6A	physical	28514442
PACE1_HUMAN	SCYL3	physical	28514442
TCPG_HUMAN	CCT3	physical	28514442
TCPD_HUMAN	CCT4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HDA11_HUMAN

Related Literatures of Post-Translational Modification