RCOR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCOR2_HUMAN
• UniProt AC: Q8IZ40
• Protein Name: REST corepressor 2
• Gene Name: RCOR2
• Organism: Homo sapiens (Human).
• Sequence Length: 523
• Subcellular Localization: Nucleus .
• Protein Description: May act as a component of a corepressor complex that represses transcription..
• Protein Sequence: MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGKKEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSVMEKPSA -----CCCCCCCCCC	32.56	21406692
9	Phosphorylation	PSVMEKPSAGSGILS CCCCCCCCCCCCCCC	57.22	21406692
12	Phosphorylation	MEKPSAGSGILSRSR CCCCCCCCCCCCCCC	23.52	21406692
22	Phosphorylation	LSRSRAKTVPNGGQP CCCCCCCCCCCCCCC	39.96	21406692
31	Phosphorylation	PNGGQPHSEDDSSEE CCCCCCCCCCCCCCC	49.78	30576142
35	Phosphorylation	QPHSEDDSSEEEHSH CCCCCCCCCCCCCCH	52.55	28450419
36	Phosphorylation	PHSEDDSSEEEHSHD CCCCCCCCCCCCCHH	56.90	28450419
41	Phosphorylation	DSSEEEHSHDSMIRV CCCCCCCCHHCCEEE	32.06	21406692
44	Phosphorylation	EEEHSHDSMIRVGTN CCCCCHHCCEEECCC	15.64	30576142
50	Phosphorylation	DSMIRVGTNYQAVIP HCCEEECCCEEEECC	28.09	26552605
52	Phosphorylation	MIRVGTNYQAVIPEC CEEECCCEEEECCCC	9.55	26552605
60	Sumoylation	QAVIPECKPESPARY EEECCCCCCCCCCCC	50.59	-
60	Sumoylation	QAVIPECKPESPARY EEECCCCCCCCCCCC	50.59	-
63	Phosphorylation	IPECKPESPARYSNK CCCCCCCCCCCCCCC	32.18	30266825
68	Phosphorylation	PESPARYSNKELKGM CCCCCCCCCCCCCCC	35.55	24850871
79	Phosphorylation	LKGMLVWSPNHCVSD CCCCEEECCCCCCCH	14.35	24719451
88	Sumoylation	NHCVSDAKLDKYIAM CCCCCHHHHHHHHHH	63.31	28112733
88	Ubiquitination	NHCVSDAKLDKYIAM CCCCCHHHHHHHHHH	63.31	32015554
91	Sumoylation	VSDAKLDKYIAMAKE CCHHHHHHHHHHHHH	49.33	-
92	Phosphorylation	SDAKLDKYIAMAKEK CHHHHHHHHHHHHHH	8.12	-
120	Ubiquitination	WHKHDVEKSLADLAN HHHHHHHHHHHHHCC	51.09	29967540
164	Ubiquitination	IQQMLPDKLIPSLVK HHHHCCHHHHHHHHH	46.51	29967540
168	Phosphorylation	LPDKLIPSLVKYYYS CCHHHHHHHHHHHHH	38.51	21406692
173	Phosphorylation	IPSLVKYYYSWKKTR HHHHHHHHHHCCCCC	5.82	22817900
174	Phosphorylation	PSLVKYYYSWKKTRS HHHHHHHHHCCCCCC	12.64	22817900
175	Phosphorylation	SLVKYYYSWKKTRSR HHHHHHHHCCCCCCC	19.12	24719451
202	Phosphorylation	GRKDKEDSDELEEGR CCCCHHCCHHHHCCC	33.79	20393185
213	Phosphorylation	EEGRGGVSEGEPDPA HCCCCCCCCCCCCCC	43.06	29255136
229	Phosphorylation	PKREPLPSRPLNARP CCCCCCCCCCCCCCC	54.97	29449344
264	Phosphorylation	RRPPKGMYLSPEGLT CCCCCCCEECCCCEE	16.82	27732954
266	Phosphorylation	PPKGMYLSPEGLTAV CCCCCEECCCCEEEC	11.92	27732954
271	Phosphorylation	YLSPEGLTAVSGSPD EECCCCEEECCCCCC	35.55	27732954
274	Phosphorylation	PEGLTAVSGSPDLAN CCCEEECCCCCCHHH	30.96	27732954
276	Phosphorylation	GLTAVSGSPDLANLT CEEECCCCCCHHHCH	14.03	27732954
283	Phosphorylation	SPDLANLTLRGLDSQ CCCHHHCHHCCHHHH	17.76	24719451
289	Phosphorylation	LTLRGLDSQLISLKR CHHCCHHHHHHHHHH	31.74	21406692
293	Phosphorylation	GLDSQLISLKRQVQS CHHHHHHHHHHHHHH	36.11	24719451
295	Ubiquitination	DSQLISLKRQVQSMK HHHHHHHHHHHHHHH	33.71	29967540
302	Ubiquitination	KRQVQSMKQTNSSLR HHHHHHHHHHCHHHH	60.25	29967540
327	Ubiquitination	RPPEANTKFNSRWTT CCCCCCCCCCCCCCC	42.21	29967540
479	Methylation	QGRFLQPRLAPNQPP CCCCCCCCCCCCCCC	30.44	54548723
479	Asymmetric dimethylarginine	QGRFLQPRLAPNQPP CCCCCCCCCCCCCCC	30.44	-
491	Methylation	QPPPPLIRPALAAPR CCCCCCCCHHHCCCC	20.37	54549457
491	Dimethylation	QPPPPLIRPALAAPR CCCCCCCCHHHCCCC	20.37	-
498	Methylation	RPALAAPRHSARPGP CHHHCCCCCCCCCCC	31.50	54549459
498	Dimethylation	RPALAAPRHSARPGP CHHHCCCCCCCCCCC	31.50	-
502	Methylation	AAPRHSARPGPQPPP CCCCCCCCCCCCCCC	39.46	54561723
502	Dimethylation	AAPRHSARPGPQPPP CCCCCCCCCCCCCCC	39.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCOR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCOR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCOR2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RCOR2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.