TTC27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC27_HUMAN
• UniProt AC: Q6P3X3
• Protein Name: Tetratricopeptide repeat protein 27
• Gene Name: TTC27
• Organism: Homo sapiens (Human).
• Sequence Length: 843
• Protein Sequence: MWTPELAILRGFPTEAERQQWKQEGVVGSESGSFLQLLLEGNYEAIFLNSMTQNIFNSTTTAEEKIDSYLEKQVVTFLDYSTDLDTTERQQLIFLLGVSSLQLFVQSNWTGPPVDLHPQDFLSSVLFQQFSEVKGLDAFVLSLLTLDGESIYSLTSKPILLLLARIILVNVRHKLTAIQSLPWWTLRCVNIHQHLLEERSPLLFTLAENCIDQVMKLQNLFVDDSGRYLAIQFHLECAYVFLYYYEYRKAKDQLDIAKDISQLQIDLTGALGKRTRFQENYVAQLILDVRREGDVLSNCEFTPAPTPQEHLTKNLELNDDTILNDIKLADCEQFQMPDLCAEEIAIILGICTNFQKNNPVHTLTEVELLAFTSCLLSQPKFWAIQTSALILRTKLEKGSTRRVERAMRQTQALADQFEDKTTSVLERLKIFYCCQVPPHWAIQRQLASLLFELGCTSSALQIFEKLEMWEDVVICYERAGQHGKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSRYRSARAQRSKALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQVLKILVRAVIDGMTDRSGDVATGLKGKLQELFGRVTSRVTNDGEIWRLYAHVYGNGQSEKPDENEKAFQCLSKAYKCDTQSNCWEKDITSFKEVVQRALGLAHVAIKCSKNKSSSQEAVQMLSSVRLNLRGLLSKAKQLFTDVATGEMSRELADDITAMDTLVTELQDLSNQFRNQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MWTPELAILR -----CCCHHHHHHC	12.94	21406692
251	Ubiquitination	YYEYRKAKDQLDIAK HHHHHHHHHHHHHHH	49.39	-
258	Ubiquitination	KDQLDIAKDISQLQI HHHHHHHHHHHHHCH	56.80	-
261	Phosphorylation	LDIAKDISQLQIDLT HHHHHHHHHHCHHHH	34.66	30622161
273	Ubiquitination	DLTGALGKRTRFQEN HHHCCCCCCCCCCHH	51.99	21906983
275	Phosphorylation	TGALGKRTRFQENYV HCCCCCCCCCCHHHH	39.04	-
281	Phosphorylation	RTRFQENYVAQLILD CCCCCHHHHHHHHHH	9.08	27642862
313	Ubiquitination	TPQEHLTKNLELNDD CCHHHHCCCCCCCCC	66.93	-
321	Phosphorylation	NLELNDDTILNDIKL CCCCCCCCHHHCCCH	30.17	20873877
393	Phosphorylation	TSALILRTKLEKGST HHHHHHHHHHHHCCH	36.21	30576142
410	Phosphorylation	VERAMRQTQALADQF HHHHHHHHHHHHHHC	12.87	-
420	Ubiquitination	LADQFEDKTTSVLER HHHHCCCHHHHHHHH	46.64	21906983
476	Phosphorylation	WEDVVICYERAGQHG CCCEEEHHHHCCCCC	9.42	23403867
484	Ubiquitination	ERAGQHGKAEEILRQ HHCCCCCCHHHHHHH	50.96	21890473
496	Ubiquitination	LRQELEKKETPSLYC HHHHHHHCCCCCHHH	58.40	-
517	Ubiquitination	GDHSCYDKAWELSRY CCCCHHHHHHHHHHH	28.99	-
524	Phosphorylation	KAWELSRYRSARAQR HHHHHHHHHHHHHHH	12.92	24719451
526	Phosphorylation	WELSRYRSARAQRSK HHHHHHHHHHHHHHH	17.11	24719451
533	Ubiquitination	SARAQRSKALLHLRN HHHHHHHHHHHHHCC	45.29	-
541	Ubiquitination	ALLHLRNKEFQECVE HHHHHCCHHHHHHHH	54.17	-
566	Phosphorylation	MQLGVWFSLGCAYLA HHHHHHHHHHHHHHH	14.24	20049867
571	Phosphorylation	WFSLGCAYLALEDYQ HHHHHHHHHHHHHHC	9.15	20049867
577	Phosphorylation	AYLALEDYQGSAKAF HHHHHHHHCCCHHHH	12.85	20049867
580	Phosphorylation	ALEDYQGSAKAFQRC HHHHHCCCHHHHHHH	15.86	20049867
662	Phosphorylation	LLDLRDKYKDVQVLK HHHHHHHCCHHHHHH	19.40	-
663	Ubiquitination	LDLRDKYKDVQVLKI HHHHHHCCHHHHHHH	58.10	-
691	Ubiquitination	GDVATGLKGKLQELF CCHHHCHHHHHHHHH	56.17	21890473
693	Ubiquitination	VATGLKGKLQELFGR HHHCHHHHHHHHHCH	45.47	-
702	Phosphorylation	QELFGRVTSRVTNDG HHHHCHHHEEECCCH	14.95	-
715	Phosphorylation	DGEIWRLYAHVYGNG CHHHEEEEEEECCCC	6.01	-
732	Ubiquitination	EKPDENEKAFQCLSK CCCCCCHHHHHHHHH	67.11	-
732	Acetylation	EKPDENEKAFQCLSK CCCCCCHHHHHHHHH	67.11	26051181
739	Ubiquitination	KAFQCLSKAYKCDTQ HHHHHHHHHHHCCCC	42.67	-
739	Acetylation	KAFQCLSKAYKCDTQ HHHHHHHHHHHCCCC	42.67	26051181
742	Ubiquitination	QCLSKAYKCDTQSNC HHHHHHHHCCCCCCC	30.41	-
752	Acetylation	TQSNCWEKDITSFKE CCCCCCCCCCHHHHH	29.90	23749302
752	Ubiquitination	TQSNCWEKDITSFKE CCCCCCCCCCHHHHH	29.90	-
756	Phosphorylation	CWEKDITSFKEVVQR CCCCCCHHHHHHHHH	34.35	-
758	Ubiquitination	EKDITSFKEVVQRAL CCCCHHHHHHHHHHH	49.74	-
773	Ubiquitination	GLAHVAIKCSKNKSS HHHHHHHHCCCCCCC	23.79	-
778	Ubiquitination	AIKCSKNKSSSQEAV HHHCCCCCCCHHHHH	56.29	-
779	Phosphorylation	IKCSKNKSSSQEAVQ HHCCCCCCCHHHHHH	44.61	24905233
780	Phosphorylation	KCSKNKSSSQEAVQM HCCCCCCCHHHHHHH	37.34	24905233
781	Phosphorylation	CSKNKSSSQEAVQML CCCCCCCHHHHHHHH	38.85	24905233
789	Phosphorylation	QEAVQMLSSVRLNLR HHHHHHHHHHHHHHH	22.80	24719451
790	Phosphorylation	EAVQMLSSVRLNLRG HHHHHHHHHHHHHHH	13.80	24905233
800	Phosphorylation	LNLRGLLSKAKQLFT HHHHHHHHHHHHHHH	35.29	24719451
803	Ubiquitination	RGLLSKAKQLFTDVA HHHHHHHHHHHHHHH	51.80	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TXLNA_HUMAN	TXLNA	physical	22939629
CJ076_HUMAN	C10orf76	physical	26344197
CD2AP_HUMAN	CD2AP	physical	26344197
GFPT1_HUMAN	GFPT1	physical	26344197
MK03_HUMAN	MAPK3	physical	26344197
NMD3_HUMAN	NMD3	physical	26344197
2A5D_HUMAN	PPP2R5D	physical	26344197
SK2L2_HUMAN	SKIV2L2	physical	26344197
TTC27_HUMAN	TTC27	physical	26472760
U5S1_HUMAN	EFTUD2	physical	26472760
U520_HUMAN	SNRNP200	physical	26472760
PRP8_HUMAN	PRPF8	physical	26472760
TCPE_HUMAN	CCT5	physical	26472760
TCPZ_HUMAN	CCT6A	physical	26472760
TCPD_HUMAN	CCT4	physical	26472760
TCPH_HUMAN	CCT7	physical	26472760
TCPB_HUMAN	CCT2	physical	26472760
AAR2_HUMAN	AAR2	physical	26472760
TCPA_HUMAN	TCP1	physical	26472760
TCPG_HUMAN	CCT3	physical	26472760
NCDN_HUMAN	NCDN	physical	26472760
ECD_HUMAN	ECD	physical	26472760

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.