dbPTM

HJURP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HJURP_HUMAN
UniProt AC	Q8NCD3
Protein Name	Holliday junction recognition protein
Gene Name	HJURP
Organism	Homo sapiens (Human).
Sequence Length	748
Subcellular Localization	Nucleus, nucleolus. Chromosome, centromere. Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Protein Description	Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions..
Protein Sequence	MLGTLRAMEGEDVEDDQLLQKLRASRRRFQRRMQRLIEKYNQPFEDTPVVQMATLTYETPQGLRIWGGRLIKERNEGEIQDSSMKPADRTDGSVQAAAWGPELPSHRTVLGADSKSGEVDATSDQEESVAWALAPAVPQSPLKNELRRKYLTQVDILLQGAEYFECAGNRAGRDVRVTPLPSLASPAVPAPGYCSRISRKSPGDPAKPASSPREWDPLHPSSTDMALVPRNDSLSLQETSSSSFLSSQPFEDDDICNVTISDLYAGMLHSMSRLLSTKPSSIISTKTFIMQNWNSRRRHRYKSRMNKTYCKGARRSQRSSKENFIPCSEPVKGTGALRDCKNVLDVSCRKTGLKLEKAFLEVNRPQIHKLDPSWKERKVTPSKYSSLIYFDSSATYNLDEENRFRTLKWLISPVKIVSRPTIRQGHGENRQREIEIRFDQLHREYCLSPRNQPRRMCLPDSWAMNMYRGGPASPGGLQGLETRRLSLPSSKAKAKSLSEAFENLGKRSLEAGRCLPKSDSSSSLPKTNPTHSATRPQQTSDLHVQGNSSGIFRKSVSPSKTLSVPDKEVPGHGRNRYDEIKEEFDKLHQKYCLKSPGQMTVPLCIGVSTDKASMEVRYQTEGFLGKLNPDPHFQGFQKLPSSPLGCRKSLLGSTAIEAPSSTCVARAITRDGTRDHQFPAKRPRLSEPQGSGRQGNSLGASDGVDNTVRPGDQGSSSQPNSEERGENTSYRMEEKSDFMLEKLETKSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Sulfoxidation	MLGTLRAMEGEDVED CCCCCCCCCCCCCCC	5.70	21406390
21	Ubiquitination	EDDQLLQKLRASRRR CCHHHHHHHHHHHHH	39.65	21906983
21 (in isoform 1)	Ubiquitination	-	39.65	21890473
21 (in isoform 2)	Ubiquitination	-	39.65	21890473
21 (in isoform 3)	Ubiquitination	-	39.65	21890473
25	Phosphorylation	LLQKLRASRRRFQRR HHHHHHHHHHHHHHH	21.64	-
39	Ubiquitination	RMQRLIEKYNQPFED HHHHHHHHHCCCCCC	42.37	22817900
39 (in isoform 1)	Ubiquitination	-	42.37	21890473
39 (in isoform 2)	Ubiquitination	-	42.37	21890473
39 (in isoform 3)	Ubiquitination	-	42.37	21890473
82	Phosphorylation	NEGEIQDSSMKPADR CCCCCCCCCCCCCCC	18.89	-
83	Phosphorylation	EGEIQDSSMKPADRT CCCCCCCCCCCCCCC	38.83	-
85	Ubiquitination	EIQDSSMKPADRTDG CCCCCCCCCCCCCCC	38.71	21906983
85 (in isoform 1)	Ubiquitination	-	38.71	21890473
116	Phosphorylation	VLGADSKSGEVDATS EECCCCCCCCCCCCC	44.10	28102081
122	Phosphorylation	KSGEVDATSDQEESV CCCCCCCCCCCHHHH	28.51	22617229
122	Ubiquitination	KSGEVDATSDQEESV CCCCCCCCCCCHHHH	28.51	29967540
123	Phosphorylation	SGEVDATSDQEESVA CCCCCCCCCCHHHHH	38.73	22617229
128	Phosphorylation	ATSDQEESVAWALAP CCCCCHHHHHHHHCC	19.18	22617229
140	Phosphorylation	LAPAVPQSPLKNELR HCCCCCCCCCCHHHH	26.57	26055452
153	Ubiquitination	LRRKYLTQVDILLQG HHHHHHHHHHHHHHC	28.43	29967540
163	Phosphorylation	ILLQGAEYFECAGNR HHHHCHHHEECCCCC	12.25	-
166	Ubiquitination	QGAEYFECAGNRAGR HCHHHEECCCCCCCC	4.16	21890473
178	Phosphorylation	AGRDVRVTPLPSLAS CCCCCEECCCCCCCC	14.45	25159151
182	Phosphorylation	VRVTPLPSLASPAVP CEECCCCCCCCCCCC	44.22	25159151
185	Phosphorylation	TPLPSLASPAVPAPG CCCCCCCCCCCCCCC	20.77	25159151
193	Phosphorylation	PAVPAPGYCSRISRK CCCCCCCCCCCCCCC	6.03	29396449
193	Ubiquitination	PAVPAPGYCSRISRK CCCCCCCCCCCCCCC	6.03	27667366
193 (in isoform 3)	Ubiquitination	-	6.03	21890473
195	Phosphorylation	VPAPGYCSRISRKSP CCCCCCCCCCCCCCC	24.94	26552605
198	Phosphorylation	PGYCSRISRKSPGDP CCCCCCCCCCCCCCC	32.33	24719451
201	Phosphorylation	CSRISRKSPGDPAKP CCCCCCCCCCCCCCC	32.76	30266825
207	Ubiquitination	KSPGDPAKPASSPRE CCCCCCCCCCCCCCC	46.64	29967540
210	Phosphorylation	GDPAKPASSPREWDP CCCCCCCCCCCCCCC	49.77	30266825
211	Phosphorylation	DPAKPASSPREWDPL CCCCCCCCCCCCCCC	30.04	30266825
221	Phosphorylation	EWDPLHPSSTDMALV CCCCCCCCCCCEEEE	34.81	22199227
222	Phosphorylation	WDPLHPSSTDMALVP CCCCCCCCCCEEEEE	32.64	22199227
223	Phosphorylation	DPLHPSSTDMALVPR CCCCCCCCCEEEEEC	33.85	22199227
224	Ubiquitination	PLHPSSTDMALVPRN CCCCCCCCEEEEECC	23.47	27667366
224 (in isoform 2)	Ubiquitination	-	23.47	21890473
236	Ubiquitination	PRNDSLSLQETSSSS ECCCCCCCEECCCCC	6.91	33845483
247	Ubiquitination	SSSSFLSSQPFEDDD CCCCCCCCCCCCCCC	43.98	33845483
256	Ubiquitination	PFEDDDICNVTISDL CCCCCCCCCEEHHHH	4.27	33845483
267	Ubiquitination	ISDLYAGMLHSMSRL HHHHHHHHHHHHHHH	2.01	33845483
269	Ubiquitination	DLYAGMLHSMSRLLS HHHHHHHHHHHHHHC	16.74	29967540
272	Ubiquitination	AGMLHSMSRLLSTKP HHHHHHHHHHHCCCC	23.85	29967540
276	Phosphorylation	HSMSRLLSTKPSSII HHHHHHHCCCCHHCE	38.69	24719451
278	Ubiquitination	MSRLLSTKPSSIIST HHHHHCCCCHHCEEE	39.26	27667366
278 (in isoform 1)	Ubiquitination	-	39.26	21890473
280	Phosphorylation	RLLSTKPSSIISTKT HHHCCCCHHCEEEHH	35.41	27732954
281	Phosphorylation	LLSTKPSSIISTKTF HHCCCCHHCEEEHHH	32.25	27732954
284	Phosphorylation	TKPSSIISTKTFIMQ CCCHHCEEEHHHHHH	23.37	27732954
284	Ubiquitination	TKPSSIISTKTFIMQ CCCHHCEEEHHHHHH	23.37	29967540
285	Phosphorylation	KPSSIISTKTFIMQN CCHHCEEEHHHHHHC	24.56	27732954
286	Ubiquitination	PSSIISTKTFIMQNW CHHCEEEHHHHHHCC	34.35	-
287	Ubiquitination	SSIISTKTFIMQNWN HHCEEEHHHHHHCCH	20.62	33845483
290	Ubiquitination	ISTKTFIMQNWNSRR EEEHHHHHHCCHHHH	1.89	33845483
296	Ubiquitination	IMQNWNSRRRHRYKS HHHCCHHHHHHHHHH	36.12	21890473
300	Ubiquitination	WNSRRRHRYKSRMNK CHHHHHHHHHHHCCH	38.47	29967540
303	Phosphorylation	RRRHRYKSRMNKTYC HHHHHHHHHCCHHHH	28.03	18452278
303	Ubiquitination	RRRHRYKSRMNKTYC HHHHHHHHHCCHHHH	28.03	29967540
315	Ubiquitination	TYCKGARRSQRSSKE HHHHHHHHHHCCCCC	36.29	29967540
321	Ubiquitination	RRSQRSSKENFIPCS HHHHCCCCCCCCCCC	58.90	33845483
323	Ubiquitination	SQRSSKENFIPCSEP HHCCCCCCCCCCCCC	43.83	21890473
323 (in isoform 3)	Ubiquitination	-	43.83	21890473
328	Phosphorylation	KENFIPCSEPVKGTG CCCCCCCCCCCCCCC	39.31	21815630
332	Ubiquitination	IPCSEPVKGTGALRD CCCCCCCCCCCHHHH	62.56	33845483
341	Acetylation	TGALRDCKNVLDVSC CCHHHHCCCCCCHHH	55.14	25953088
341	Ubiquitination	TGALRDCKNVLDVSC CCHHHHCCCCCCHHH	55.14	33845483
347	Phosphorylation	CKNVLDVSCRKTGLK CCCCCCHHHHHHCCC	14.10	21815630
354	Sumoylation	SCRKTGLKLEKAFLE HHHHHCCCHHHHHHH	56.81	28112733
354	Ubiquitination	SCRKTGLKLEKAFLE HHHHHCCCHHHHHHH	56.81	23000965
354 (in isoform 2)	Ubiquitination	-	56.81	21890473
357	Ubiquitination	KTGLKLEKAFLEVNR HHCCCHHHHHHHCCC	55.67	29967540
369	Ubiquitination	VNRPQIHKLDPSWKE CCCHHHHCCCCCHHH	57.10	29967540
375	Ubiquitination	HKLDPSWKERKVTPS HCCCCCHHHCCCCHH	52.56	33845483
380	O-linked_Glycosylation	SWKERKVTPSKYSSL CHHHCCCCHHHCCEE	25.53	30379171
380	Phosphorylation	SWKERKVTPSKYSSL CHHHCCCCHHHCCEE	25.53	24719451
382	Phosphorylation	KERKVTPSKYSSLIY HHCCCCHHHCCEEEE	34.56	-
401	Phosphorylation	ATYNLDEENRFRTLK CCCCCCCHHCHHHHH	54.06	32142685
408	Sumoylation	ENRFRTLKWLISPVK HHCHHHHHHHHCCCE	39.06	-
408	Sumoylation	ENRFRTLKWLISPVK HHCHHHHHHHHCCCE	39.06	-
408	Ubiquitination	ENRFRTLKWLISPVK HHCHHHHHHHHCCCE	39.06	23000965
408 (in isoform 1)	Ubiquitination	-	39.06	21890473
410	Ubiquitination	RFRTLKWLISPVKIV CHHHHHHHHCCCEEE	2.38	29967540
412	Phosphorylation	RTLKWLISPVKIVSR HHHHHHHCCCEEECC	22.82	19664994
415	Ubiquitination	KWLISPVKIVSRPTI HHHHCCCEEECCCCC	40.55	-
418	Phosphorylation	ISPVKIVSRPTIRQG HCCCEEECCCCCCCC	35.70	22468782
421	Phosphorylation	VKIVSRPTIRQGHGE CEEECCCCCCCCCCC	27.90	23312004
421	Ubiquitination	VKIVSRPTIRQGHGE CEEECCCCCCCCCCC	27.90	29967540
432	Phosphorylation	GHGENRQREIEIRFD CCCCCCCEEEEEEHH	43.56	32142685
432	Ubiquitination	GHGENRQREIEIRFD CCCCCCCEEEEEEHH	43.56	29967540
441	Ubiquitination	IEIRFDQLHREYCLS EEEEHHHHHHHHHCC	4.41	29967540
445	Phosphorylation	FDQLHREYCLSPRNQ HHHHHHHHHCCCCCC	9.92	29396449
448	Phosphorylation	LHREYCLSPRNQPRR HHHHHHCCCCCCCCC	20.46	19664994
452	Ubiquitination	YCLSPRNQPRRMCLP HHCCCCCCCCCCCCC	33.87	29967540
461	Phosphorylation	RRMCLPDSWAMNMYR CCCCCCCHHHHHCCC	18.13	24043423
463	Ubiquitination	MCLPDSWAMNMYRGG CCCCCHHHHHCCCCC	5.39	29967540
467	Phosphorylation	DSWAMNMYRGGPASP CHHHHHCCCCCCCCC	10.91	24043423
472	Phosphorylation	NMYRGGPASPGGLQG HCCCCCCCCCCCCCC	31.47	32645325
472	Ubiquitination	NMYRGGPASPGGLQG HCCCCCCCCCCCCCC	31.47	29967540
473	Phosphorylation	MYRGGPASPGGLQGL CCCCCCCCCCCCCCH	27.49	19664994
482	Phosphorylation	GGLQGLETRRLSLPS CCCCCHHHCCCCCCC	26.57	23927012
482	Ubiquitination	GGLQGLETRRLSLPS CCCCCHHHCCCCCCC	26.57	29967540
486	Phosphorylation	GLETRRLSLPSSKAK CHHHCCCCCCCHHHH	36.10	23401153
489	Phosphorylation	TRRLSLPSSKAKAKS HCCCCCCCHHHHHHH	50.17	22617229
490	Phosphorylation	RRLSLPSSKAKAKSL CCCCCCCHHHHHHHH	34.39	25159151
493	Ubiquitination	SLPSSKAKAKSLSEA CCCCHHHHHHHHHHH	61.15	-
495	Sumoylation	PSSKAKAKSLSEAFE CCHHHHHHHHHHHHH	51.74	-
495	Methylation	PSSKAKAKSLSEAFE CCHHHHHHHHHHHHH	51.74	82974403
495	Sumoylation	PSSKAKAKSLSEAFE CCHHHHHHHHHHHHH	51.74	-
495	Ubiquitination	PSSKAKAKSLSEAFE CCHHHHHHHHHHHHH	51.74	29967540
496	Phosphorylation	SSKAKAKSLSEAFEN CHHHHHHHHHHHHHH	41.82	25159151
496	Ubiquitination	SSKAKAKSLSEAFEN CHHHHHHHHHHHHHH	41.82	29967540
498	Phosphorylation	KAKAKSLSEAFENLG HHHHHHHHHHHHHHH	33.69	27050516
501	Ubiquitination	AKSLSEAFENLGKRS HHHHHHHHHHHHHHH	5.85	29967540
503	Phosphorylation	SLSEAFENLGKRSLE HHHHHHHHHHHHHHH	47.87	32645325
505	Ubiquitination	SEAFENLGKRSLEAG HHHHHHHHHHHHHHC	34.61	29967540
506	Acetylation	EAFENLGKRSLEAGR HHHHHHHHHHHHHCC	41.81	25953088
506	Methylation	EAFENLGKRSLEAGR HHHHHHHHHHHHHCC	41.81	115970695
506	Ubiquitination	EAFENLGKRSLEAGR HHHHHHHHHHHHHCC	41.81	29967540
508	Phosphorylation	FENLGKRSLEAGRCL HHHHHHHHHHHCCCC	33.76	-
509	Ubiquitination	ENLGKRSLEAGRCLP HHHHHHHHHHCCCCC	6.41	29967540
513	Ubiquitination	KRSLEAGRCLPKSDS HHHHHHCCCCCCCCC	26.33	29967540
517	Sumoylation	EAGRCLPKSDSSSSL HHCCCCCCCCCCCCC	54.68	-
517	Sumoylation	EAGRCLPKSDSSSSL HHCCCCCCCCCCCCC	54.68	-
517	Ubiquitination	EAGRCLPKSDSSSSL HHCCCCCCCCCCCCC	54.68	29967540
518	Phosphorylation	AGRCLPKSDSSSSLP HCCCCCCCCCCCCCC	40.56	26852163
520	Phosphorylation	RCLPKSDSSSSLPKT CCCCCCCCCCCCCCC	38.93	21815630
521	Phosphorylation	CLPKSDSSSSLPKTN CCCCCCCCCCCCCCC	29.01	29396449
522	Phosphorylation	LPKSDSSSSLPKTNP CCCCCCCCCCCCCCC	39.59	29396449
523	Phosphorylation	PKSDSSSSLPKTNPT CCCCCCCCCCCCCCC	51.11	29396449
526	Ubiquitination	DSSSSLPKTNPTHSA CCCCCCCCCCCCCCC	67.25	29967540
527	Ubiquitination	SSSSLPKTNPTHSAT CCCCCCCCCCCCCCC	44.48	29967540
532	Phosphorylation	PKTNPTHSATRPQQT CCCCCCCCCCCCCCC	33.54	25627689
532	Ubiquitination	PKTNPTHSATRPQQT CCCCCCCCCCCCCCC	33.54	29967540
534	Phosphorylation	TNPTHSATRPQQTSD CCCCCCCCCCCCCCE	45.99	28555341
536	Ubiquitination	PTHSATRPQQTSDLH CCCCCCCCCCCCEEE	26.69	29967540
539	Phosphorylation	SATRPQQTSDLHVQG CCCCCCCCCEEEECC	20.97	28555341
540	Ubiquitination	ATRPQQTSDLHVQGN CCCCCCCCEEEECCC	33.56	29967540
541	Ubiquitination	TRPQQTSDLHVQGNS CCCCCCCEEEECCCC	44.15	29967540
549	Phosphorylation	LHVQGNSSGIFRKSV EEECCCCCCCEECCC	39.65	28555341
553	Ubiquitination	GNSSGIFRKSVSPSK CCCCCCEECCCCCCC	28.55	29967540
555	Phosphorylation	SSGIFRKSVSPSKTL CCCCEECCCCCCCCC	24.46	23927012
557	Phosphorylation	GIFRKSVSPSKTLSV CCEECCCCCCCCCCC	30.46	23401153
559	Phosphorylation	FRKSVSPSKTLSVPD EECCCCCCCCCCCCC	30.66	28464451
561	Phosphorylation	KSVSPSKTLSVPDKE CCCCCCCCCCCCCCC	28.71	28464451
563	Phosphorylation	VSPSKTLSVPDKEVP CCCCCCCCCCCCCCC	36.51	28464451
563	Ubiquitination	VSPSKTLSVPDKEVP CCCCCCCCCCCCCCC	36.51	29967540
567	Acetylation	KTLSVPDKEVPGHGR CCCCCCCCCCCCCCC	55.32	25953088
567	Ubiquitination	KTLSVPDKEVPGHGR CCCCCCCCCCCCCCC	55.32	29967540
572	Ubiquitination	PDKEVPGHGRNRYDE CCCCCCCCCCCCHHH	26.43	29967540
581	Sumoylation	RNRYDEIKEEFDKLH CCCHHHHHHHHHHHH	49.49	-
581	Sumoylation	RNRYDEIKEEFDKLH CCCHHHHHHHHHHHH	49.49	28112733
581	Ubiquitination	RNRYDEIKEEFDKLH CCCHHHHHHHHHHHH	49.49	29967540
584	Ubiquitination	YDEIKEEFDKLHQKY HHHHHHHHHHHHHHH	12.00	29967540
586	Sumoylation	EIKEEFDKLHQKYCL HHHHHHHHHHHHHCC	53.87	28112733
586	Ubiquitination	EIKEEFDKLHQKYCL HHHHHHHHHHHHHCC	53.87	29967540
590	Ubiquitination	EFDKLHQKYCLKSPG HHHHHHHHHCCCCCC	27.47	29967540
591	Phosphorylation	FDKLHQKYCLKSPGQ HHHHHHHHCCCCCCC	9.10	29083192
594	Ubiquitination	LHQKYCLKSPGQMTV HHHHHCCCCCCCCEE	51.55	29967540
595	Phosphorylation	HQKYCLKSPGQMTVP HHHHCCCCCCCCEEE	22.70	29255136
596	Ubiquitination	QKYCLKSPGQMTVPL HHHCCCCCCCCEEEE	35.13	29967540
600	Phosphorylation	LKSPGQMTVPLCIGV CCCCCCCEEEEEEEE	15.87	29255136
608	Phosphorylation	VPLCIGVSTDKASME EEEEEEEECCCCCCE	26.19	22199227
609	Phosphorylation	PLCIGVSTDKASMEV EEEEEEECCCCCCEE	38.83	22199227
611	Ubiquitination	CIGVSTDKASMEVRY EEEEECCCCCCEEEE	42.31	-
626	Acetylation	QTEGFLGKLNPDPHF CCCCCHHCCCCCCCC	47.43	25953088
626	Ubiquitination	QTEGFLGKLNPDPHF CCCCCHHCCCCCCCC	47.43	29967540
627	Ubiquitination	TEGFLGKLNPDPHFQ CCCCHHCCCCCCCCC	12.19	29967540
638	Ubiquitination	PHFQGFQKLPSSPLG CCCCCCCCCCCCCCC	61.17	29967540
641	Phosphorylation	QGFQKLPSSPLGCRK CCCCCCCCCCCCCCH	55.83	30266825
642	Phosphorylation	GFQKLPSSPLGCRKS CCCCCCCCCCCCCHH	23.39	29255136
648	Sumoylation	SSPLGCRKSLLGSTA CCCCCCCHHHHCCCC	49.92	-
648	Sumoylation	SSPLGCRKSLLGSTA CCCCCCCHHHHCCCC	49.92	-
648	Ubiquitination	SSPLGCRKSLLGSTA CCCCCCCHHHHCCCC	49.92	29967540
649	Phosphorylation	SPLGCRKSLLGSTAI CCCCCCHHHHCCCCE	14.96	22199227
653	Phosphorylation	CRKSLLGSTAIEAPS CCHHHHCCCCEECCC	18.03	30576142
654	Phosphorylation	RKSLLGSTAIEAPSS CHHHHCCCCEECCCC	29.83	30576142
660	Phosphorylation	STAIEAPSSTCVARA CCCEECCCCCEEEEE	45.38	29396449
661	Phosphorylation	TAIEAPSSTCVARAI CCEECCCCCEEEEEH	25.43	28555341
662	Phosphorylation	AIEAPSSTCVARAIT CEECCCCCEEEEEHH	18.48	29396449
681	Ubiquitination	RDHQFPAKRPRLSEP CCCCCCCCCCCCCCC	64.27	29967540
686	Phosphorylation	PAKRPRLSEPQGSGR CCCCCCCCCCCCCCC	48.81	21815630
691	Phosphorylation	RLSEPQGSGRQGNSL CCCCCCCCCCCCCCC	26.09	23532336
707	Phosphorylation	ASDGVDNTVRPGDQG CCCCCCCCCCCCCCC	17.27	28985074
735	Sumoylation	TSYRMEEKSDFMLEK CCCCHHHHCHHHHHH	41.86	-
735	Sumoylation	TSYRMEEKSDFMLEK CCCCHHHHCHHHHHH	41.86	-
736	Phosphorylation	SYRMEEKSDFMLEKL CCCHHHHCHHHHHHH	39.08	-
739	Sulfoxidation	MEEKSDFMLEKLETK HHHHCHHHHHHHHCC	5.92	21406390
742	Sumoylation	KSDFMLEKLETKSV- HCHHHHHHHHCCCC-	47.89	-
742	Sumoylation	KSDFMLEKLETKSV- HCHHHHHHHHCCCC-	47.89	-
745	Phosphorylation	FMLEKLETKSV---- HHHHHHHCCCC----	38.77	23312004
747	Phosphorylation	LEKLETKSV------ HHHHHCCCC------	40.24	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
412	S	Phosphorylation	Kinase	CDK1	P06493	PSP
448	S	Phosphorylation	Kinase	CDK1	P06493	PSP
473	S	Phosphorylation	Kinase	CDK1	P06493	PSP
486	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HJURP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HJURP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIC60_HUMAN	IMMT	physical	16169070
CENPA_YEAST	CSE4	genetic	21980305
CENPA_HUMAN	CENPA	genetic	21980305
CENPA_HUMAN	CENPA	physical	19410545
CENPA_HUMAN	CENPA	physical	19410544
CENPA_HUMAN	CENPA	physical	21478274
CENPA_HUMAN	CENPA	physical	20080577
RUVB1_HUMAN	RUVBL1	physical	20080577
RUVB2_HUMAN	RUVBL2	physical	20080577
RBBP7_HUMAN	RBBP7	physical	20080577
RBBP4_HUMAN	RBBP4	physical	20080577
NPM_HUMAN	NPM1	physical	20080577
CENPA_XENLA	cenpa	physical	21321101
CENPA_HUMAN	CENPA	physical	22406139
TBA3C_HUMAN	TUBA3C	physical	26186194
MS18A_HUMAN	MIS18A	physical	26186194
DUS1L_HUMAN	DUS1L	physical	26186194
CENPA_HUMAN	CENPA	physical	25727006
DUS1L_HUMAN	DUS1L	physical	28514442
TBA3C_HUMAN	TUBA3C	physical	28514442
MS18A_HUMAN	MIS18A	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HJURP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185; SER-473 ANDSER-642, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-122; SER-140; SER-412;SER-448; SER-473 AND SER-642, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-486 ANDSER-642, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-642, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Identification of FAKTS as a novel 14-3-3-associated nuclearprotein."; Luhn P., Wang H., Marcus A.I., Fu H.; Proteins 67:479-489(2007). Cited for: INTERACTION WITH 14-3-3 PROTEINS, SUBCELLULAR LOCATION, TISSUESPECIFICITY, PHOSPHORYLATION AT SER-486, AND MUTAGENESIS OF SER-486.	17256767 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-473, ANDMASS SPECTROMETRY.	16964243 [Abstract]