dbPTM

S2542_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	S2542_HUMAN
UniProt AC	Q86VD7
Protein Name	Mitochondrial coenzyme A transporter SLC25A42
Gene Name	SLC25A42
Organism	Homo sapiens (Human).
Sequence Length	318
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate..
Protein Sequence	MGNGVKEGPVRLHEDAEAVLSSSVSSKRDHRQVLSSLLSGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDLMQILLRHLQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	EDAEAVLSSSVSSKR CCHHHHHCCCCCCCH	17.61	22468782
23	Phosphorylation	AEAVLSSSVSSKRDH HHHHHCCCCCCCHHH	23.73	22817900
25	Phosphorylation	AVLSSSVSSKRDHRQ HHHCCCCCCCHHHHH	31.90	22817900
26	Phosphorylation	VLSSSVSSKRDHRQV HHCCCCCCCHHHHHH	29.56	22817900
35	Phosphorylation	RDHRQVLSSLLSGAL HHHHHHHHHHHHHHH	21.78	22817900
36	Phosphorylation	DHRQVLSSLLSGALA HHHHHHHHHHHHHHH	29.21	22817900
39	Phosphorylation	QVLSSLLSGALAGAL HHHHHHHHHHHHHHH	27.58	-
56	Methylation	TAVAPLDRTKIIFQV HCCCCCCCCEEEEEE	45.67	24383637
88	Phosphorylation	YLNEGFLSLWRGNSA HHCCCHHHHHCCCCC	24.51	24719451
96	Phosphorylation	LWRGNSATMVRVVPY HHCCCCCEEEEEEEC	18.93	28857561
120	Phosphorylation	EYKRILGSYYGFRGE HHHHHHHHHCCCCCC	16.25	-
149	Phosphorylation	GTTAASLTYPLDLVR CCCHHHCCCCHHHHH	22.16	28258704
167	Phosphorylation	AVTPKEMYSNIFHVF CCCHHHHHHCHHHHH	10.31	28122231
168	Phosphorylation	VTPKEMYSNIFHVFI CCHHHHHHCHHHHHH	23.34	28122231
256	Phosphorylation	VVRRRMQTAGVTGYP HHHHHHHHCCCCCCC	18.94	22210691
262	Phosphorylation	QTAGVTGYPRASIAR HHCCCCCCCHHHHHH	4.71	25884760
266	Phosphorylation	VTGYPRASIARTLRT CCCCCHHHHHHHHHH	20.33	22210691
270	Phosphorylation	PRASIARTLRTIVRE CHHHHHHHHHHHHHH	16.15	22210691
273	Phosphorylation	SIARTLRTIVREEGA HHHHHHHHHHHHCCH	27.26	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of S2542_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of S2542_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of S2542_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of S2542_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of S2542_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-36, AND MASSSPECTROMETRY.	18187866 [Abstract]