KLF15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF15_HUMAN
• UniProt AC: Q9UIH9
• Protein Name: Krueppel-like factor 15
• Gene Name: KLF15
• Organism: Homo sapiens (Human).
• Sequence Length: 416
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation..
• Protein Sequence: MVDHLLPVDENFSSPKCPVGYLGDRLVGRRAYHMLPSPVSEDDSDASSPCSCSSPDSQALCSCYGGGLGTESQDSILDFLLSQATLGSGGGSGSSIGASSGPVAWGPWRRAAAPVKGEHFCLPEFPLGDPDDVPRPFQPTLEEIEEFLEENMEPGVKEVPEGNSKDLDACSQLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIPVLLQIQPVPVKQESGTGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPSKFVRIAPVPIAAKPVGSGPLGPGPAGLLMGQKFPKNPAAELIKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRSVRSVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Phosphorylation	KSHLHPGSSGRERCS CCCCCCCCCCCCCCC	33.79	-
187	Phosphorylation	SHLHPGSSGRERCSP CCCCCCCCCCCCCCC	48.02	-
232	Phosphorylation	PVPVKQESGTGPASP EEECCCCCCCCCCCC	38.88	25072903
234	Phosphorylation	PVKQESGTGPASPGQ ECCCCCCCCCCCCCC	49.63	25072903
238	Phosphorylation	ESGTGPASPGQAPEN CCCCCCCCCCCCCCC	32.47	25072903
276	Phosphorylation	SSNLNLPSKFVRIAP CCCCCCCCCCEEEEC	41.72	24719451
339	Sumoylation	YTKSSHLKAHLRRHT CCCHHHHHHHHHHHC	28.47	-
339	Sumoylation	YTKSSHLKAHLRRHT CCCHHHHHHHHHHHC	28.47	-
339	Ubiquitination	YTKSSHLKAHLRRHT CCCHHHHHHHHHHHC	28.47	-
346	Phosphorylation	KAHLRRHTGEKPFAC HHHHHHHCCCCCEEE	45.27	23532336
397	Phosphorylation	FARSDHLSKHIKVHR HCCCHHHHHHCEEEE	20.83	27080861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLF15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2B_HUMAN	KAT2B	physical	18586263
TCF21_HUMAN	TCF21	physical	21988832
SNX13_HUMAN	SNX13	physical	21988832
SUV91_HUMAN	SUV39H1	physical	23455924
EP300_HUMAN	EP300	physical	23999430
VWA2_HUMAN	VWA2	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
ADDG_HUMAN	ADD3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.