dbPTM

TCF21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TCF21_HUMAN
UniProt AC	O43680
Protein Name	Transcription factor 21
Gene Name	TCF21
Organism	Homo sapiens (Human).
Sequence Length	179
Subcellular Localization	Nucleus.
Protein Description	Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types..
Protein Sequence	MSTGSLSDVEDLQEVEMLECDGLKMDSNKEFVTSNESTEESSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPESDLKEVVTASRLCGTTAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Sumoylation	MLECDGLKMDSNKEF EEECCCEEECCCCCE	46.31	-
24	Sumoylation	MLECDGLKMDSNKEF EEECCCEEECCCCCE	46.31	-
42	Phosphorylation	NESTEESSNCENGSP CCCCCCCCCCCCCCC	49.10	26657352
67	Phosphorylation	RKAPTKKSPLSGVSQ CCCCCCCCCCCCCCH	32.40	26657352
100	Phosphorylation	RVLSKAFSRLKTTLP HHHHHHHHHHHHCCC	41.38	26437602
140	Phosphorylation	QILANDKYENGYIHP HHHHCCCCCCCCEEC	19.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TCF21_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TCF21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TCF21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APLP1_HUMAN	APLP1	physical	16169070
TF3C5_HUMAN	GTF3C5	physical	20211142
TFE2_HUMAN	TCF3	physical	21771727
ITF2_HUMAN	TCF4	physical	21771727
HTF4_HUMAN	TCF12	physical	21771727

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TCF21_HUMAN

Related Literatures of Post-Translational Modification