| UniProt ID | VWA2_HUMAN | |
|---|---|---|
| UniProt AC | Q5GFL6 | |
| Protein Name | von Willebrand factor A domain-containing protein 2 | |
| Gene Name | VWA2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 755 | |
| Subcellular Localization | Secreted. | |
| Protein Description | ||
| Protein Sequence | MPPFLLLEAVCVFLFSRVPPSLPLQEVHVSKETIGKISAASKMMWCSAAVDIMFLLDGSNSVGKGSFERSKHFAITVCDGLDISPERVRVGAFQFSSTPHLEFPLDSFSTQQEVKARIKRMVFKGGRTETELALKYLLHRGLPGGRNASVPQILIIVTDGKSQGDVALPSKQLKERGVTVFAVGVRFPRWEELHALASEPRGQHVLLAEQVEDATNGLFSTLSSSAICSSATPDCRVEAHPCEHRTLEMVREFAGNAPCWRGSRRTLAVLAAHCPFYSWKRVFLTHPATCYRTTCPGPCDSQPCQNGGTCVPEGLDGYQCLCPLAFGGEANCALKLSLECRVDLLFLLDSSAGTTLDGFLRAKVFVKRFVRAVLSEDSRARVGVATYSRELLVAVPVGEYQDVPDLVWSLDGIPFRGGPTLTGSALRQAAERGFGSATRTGQDRPRRVVVLLTESHSEDEVAGPARHARARELLLLGVGSEAVRAELEEITGSPKHVMVYSDPQDLFNQIPELQGKLCSRQRPGCRTQALDLVFMLDTSASVGPENFAQMQSFVRSCALQFEVNPDVTQVGLVVYGSQVQTAFGLDTKPTRAAMLRAISQAPYLGGVGSAGTALLHIYDKVMTVQRGARPGVPKAVVVLTGGRGAEDAAVPAQKLRNNGISVLVVGVGPVLSEGLRRLAGPRDSLIHVAAYADLRYHQDVLIEWLCGEAKQPVNLCKPSPCMNEGSCVLQNGSYRCKCRDGWEGPHCENRFLRRP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 147 | N-linked_Glycosylation | RGLPGGRNASVPQIL CCCCCCCCCCCCEEE | 39.58 | UniProtKB CARBOHYD | |
| 170 | Phosphorylation | QGDVALPSKQLKERG CCCEECCHHHHHHCC | 33.61 | 24719451 | |
| 375 | Phosphorylation | RFVRAVLSEDSRARV HHHHHHHCCCCHHCE | 32.53 | 30631047 | |
| 491 | Phosphorylation | RAELEEITGSPKHVM HHHHHHHHCCCCEEE | 34.58 | - | |
| 493 | Phosphorylation | ELEEITGSPKHVMVY HHHHHHCCCCEEEEE | 23.33 | - | |
| 527 | Phosphorylation | RQRPGCRTQALDLVF CCCCCCHHHHHHEEE | 23.44 | 26074081 | |
| 538 | Phosphorylation | DLVFMLDTSASVGPE HEEEEECCCCCCCHH | 23.41 | 26074081 | |
| 539 | Phosphorylation | LVFMLDTSASVGPEN EEEEECCCCCCCHHH | 20.43 | 26074081 | |
| 541 | Phosphorylation | FMLDTSASVGPENFA EEECCCCCCCHHHHH | 27.63 | 26074081 | |
| 552 | Phosphorylation | ENFAQMQSFVRSCAL HHHHHHHHHHHHHHH | 21.99 | 26074081 | |
| 684 | Phosphorylation | RLAGPRDSLIHVAAY HHHCCCCHHHHHHHH | 30.42 | - | |
| 726 | Phosphorylation | SPCMNEGSCVLQNGS CCCCCCCCEEEECCC | 8.55 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VWA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VWA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VWA2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TC1D2_HUMAN | TCTEX1D2 | physical | 28514442 | |
| UBB_HUMAN | UBB | physical | 28514442 | |
| HSP7C_HUMAN | HSPA8 | physical | 28514442 | |
| WDR47_HUMAN | WDR47 | physical | 28514442 | |
| HSP72_HUMAN | HSPA2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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