HDAC6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HDAC6_MOUSE
• UniProt AC: Q9Z2V5
• Protein Name: Histone deacetylase 6
• Gene Name: Hdac6
• Organism: Mus musculus (Mouse).
• Sequence Length: 1149
• Subcellular Localization: Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. It is mainly cytoplasmic, where it is associated with microtubules.
• Protein Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.; In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (By similarity)..
• Protein Sequence: MTSTGQDSSTRQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNLAEVKKKGKMKKLSQPAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPESPERLHAIREQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDSVYLHPNSYSCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKKHRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQGYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLGDPCPMLESCVVPCASAQTSIYCTLEALEPFWEVLERSVETQEEDEVEEAVLEEEEEEGGWEATALPMDTWPLLQNRTGLVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHREGANFDSIYICPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLTLLRPPQSGALVSISEVIQVHRKYWRSLRLMKMEDKEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSKMAKAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASAAAPENFPNQTTSVEALGETEPTPPASHTNKQTTGASPLQGVTAQQSLQLGVLSTLELSREAEEAHDSEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNKFGEDMPHSH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MTSTGQDSSTR ----CCCCCCCHHHH	46.42	28576409
15	Phosphorylation	SSTRQRKSRHNPQSP HHHHHHHHCCCCCCC	40.75	19367708
21	Phosphorylation	KSRHNPQSPLQESSA HHCCCCCCCHHHCCH	28.91	25521595
26	Phosphorylation	PQSPLQESSATLKRG CCCCHHHCCHHHHCC	16.59	26643407
27	Phosphorylation	QSPLQESSATLKRGG CCCHHHCCHHHHCCC	25.23	26643407
29	Phosphorylation	PLQESSATLKRGGKK CHHHCCHHHHCCCEE	34.46	21454597
32	Methylation	ESSATLKRGGKKCAV HCCHHHHCCCEECCC	63.31	24129315
42	Phosphorylation	KKCAVPHSSPNLAEV EECCCCCCCCCHHHH	41.23	26824392
43	Phosphorylation	KCAVPHSSPNLAEVK ECCCCCCCCCHHHHH	18.12	27087446
59	Phosphorylation	KGKMKKLSQPAEEDL HCCCCCCCCCHHHCC	42.89	26824392
107	Phosphorylation	WDDSFPESPERLHAI CCCCCCCCHHHHHHH	32.09	-
857	Phosphorylation	VIKKLPPTASPVSAK EEEECCCCCCCCCCC	37.52	26239621
859	Phosphorylation	KKLPPTASPVSAKEM EECCCCCCCCCCCCC	28.45	21082442
862	Phosphorylation	PPTASPVSAKEMTTP CCCCCCCCCCCCCCC	36.69	26745281
909	Phosphorylation	AVLAQGQSSEQAAKG HHHHCCCCHHHHHCC	42.54	27087446
910	Phosphorylation	VLAQGQSSEQAAKGT HHHCCCCHHHHHCCC	26.32	21183079
923	Phosphorylation	GTTLDLATSKETVGG CCCEEECCCCCCCCC	47.86	27841257
924	Phosphorylation	TTLDLATSKETVGGA CCEEECCCCCCCCCH	23.92	27841257
958	Phosphorylation	SVEALGETEPTPPAS CEEECCCCCCCCCCC	45.53	-
961	Phosphorylation	ALGETEPTPPASHTN ECCCCCCCCCCCCCC	35.35	22067460
967	Phosphorylation	PTPPASHTNKQTTGA CCCCCCCCCCCCCCC	41.43	-
971	Phosphorylation	ASHTNKQTTGASPLQ CCCCCCCCCCCCCCC	28.89	-
975	Phosphorylation	NKQTTGASPLQGVTA CCCCCCCCCCCCCCH	27.73	-
1034	Phosphorylation	QGFGDFNTQDVFYAV CCCCCCCHHHCEEEE	26.58	-
1148	Phosphorylation	FGEDMPHSH------ CCCCCCCCC------	25.64	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HDAC6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HDAC6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HDAC6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	11689694
PLAP_MOUSE	Plaa	physical	11689694
TBA1A_MOUSE	Tuba1a	physical	12486003
HS90B_MOUSE	Hsp90ab1	physical	15916966
HDAC6_HUMAN	HDAC6	physical	20360068
GARS_HUMAN	GARS	physical	20360068
PLAP_HUMAN	PLAA	physical	20360068
UBP47_HUMAN	USP47	physical	20360068
UBC_MOUSE	Ubc	physical	16810319
TERA_MOUSE	Vcp	physical	16810319
FBX32_MOUSE	Fbxo32	physical	25516595
KAT5_MOUSE	Kat5	physical	24302573
EP400_MOUSE	Ep400	physical	24302573
ODBA_HUMAN	BCKDHA	physical	26496610
ODBB_HUMAN	BCKDHB	physical	26496610
ODB2_HUMAN	DBT	physical	26496610
ODP2_HUMAN	DLAT	physical	26496610
DLDH_HUMAN	DLD	physical	26496610
ODO2_HUMAN	DLST	physical	26496610
IREB2_HUMAN	IREB2	physical	26496610
MKLN1_HUMAN	MKLN1	physical	26496610
ODO1_HUMAN	OGDH	physical	26496610
ODPA_HUMAN	PDHA1	physical	26496610
ODPB_HUMAN	PDHB	physical	26496610
PDK2_HUMAN	PDK2	physical	26496610
SRSF3_HUMAN	SRSF3	physical	26496610
TDG_HUMAN	TDG	physical	26496610
TERA_HUMAN	VCP	physical	26496610
ODPX_HUMAN	PDHX	physical	26496610
PLAP_HUMAN	PLAA	physical	26496610
VINEX_HUMAN	SORBS3	physical	26496610
HPS5_HUMAN	HPS5	physical	26496610
KAT6B_HUMAN	KAT6B	physical	26496610
UBP47_HUMAN	USP47	physical	26496610
TTC7A_HUMAN	TTC7A	physical	26496610
IFIH1_HUMAN	IFIH1	physical	26496610
MILK2_HUMAN	MICALL2	physical	26496610
RT36_HUMAN	MRPS36	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND MASSSPECTROMETRY.
PubMed: 19367708