PLAP_MOUSE - dbPTM
PLAP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLAP_MOUSE
UniProt AC P27612
Protein Name Phospholipase A-2-activating protein
Gene Name Plaa
Organism Mus musculus (Mouse).
Sequence Length 794
Subcellular Localization Nucleus . Cytoplasm . Cell junction, synapse . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.
Protein Description Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. [PubMed: 28413018 May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity Plays a role in cerebellar Purkinje cell development]
Protein Sequence MASGASRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFLGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLENGDIVVGASDGIIRVFTESEERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLSEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMTGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKPTAQQLQILWKAINWPEDIVFPALDILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYVSVSEPAKVSECCRLVLHLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationTRLWAPDSPNRGFTE
CCEECCCCCCCCCCE		24.0229233185
311AcetylationTASAEEIKAFERELS
CCCHHHHHHHHHHHH		50.7523954790
311UbiquitinationTASAEEIKAFERELS
CCCHHHHHHHHHHHH		50.7522790023
318PhosphorylationKAFERELSQATIDSK
HHHHHHHHHCCCCCC		17.0230635358
321PhosphorylationERELSQATIDSKTGD
HHHHHHCCCCCCCCC		20.0629899451
325UbiquitinationSQATIDSKTGDLGDI
HHCCCCCCCCCCCCC		53.4222790023
326PhosphorylationQATIDSKTGDLGDIN
HCCCCCCCCCCCCCC		39.6230352176
393UbiquitinationANQQTSGKVLYEGKE
CCCCCCCEEEECCCE		28.9122790023
456UbiquitinationKFIIDNTKGQTLGLG
HHHCCCCCCCEEECC		56.1022790023
459PhosphorylationIDNTKGQTLGLGNTS
CCCCCCCEEECCCCC		31.3125777480
465PhosphorylationQTLGLGNTSFSDPFT
CEEECCCCCCCCCCC		29.3821149613
466PhosphorylationTLGLGNTSFSDPFTG
EEECCCCCCCCCCCC		27.1027149854
468PhosphorylationGLGNTSFSDPFTGGG
ECCCCCCCCCCCCCC		44.1121149613
472PhosphorylationTSFSDPFTGGGRYVP
CCCCCCCCCCCCCCC		40.0625777480
477PhosphorylationPFTGGGRYVPGTSGP
CCCCCCCCCCCCCCC		17.8026643407
481PhosphorylationGGRYVPGTSGPSNTV
CCCCCCCCCCCCCCE		25.1726643407
482PhosphorylationGRYVPGTSGPSNTVQ
CCCCCCCCCCCCCEE		55.4026643407
485PhosphorylationVPGTSGPSNTVQTAD
CCCCCCCCCCEECCC		48.9726643407
487PhosphorylationGTSGPSNTVQTADPF
CCCCCCCCEECCCCC		20.5226643407
490PhosphorylationGPSNTVQTADPFTGA
CCCCCEECCCCCCCC		28.7926643407
504PhosphorylationAGRYMPGSAGMDTTM
CCCCCCCCCCCCCCC		18.7725338131
529AcetylationAYRSAASKTVNIYFP
HHHHHCCCEEEEEEC		52.3323806337
538UbiquitinationVNIYFPKKEALTFDQ
EEEEECCCCEECCCC		48.75-
554AcetylationNPTQILGKLKELNGT
CHHHHHHHHHHHCCC		53.6023954790
554UbiquitinationNPTQILGKLKELNGT
CHHHHHHHHHHHCCC		53.6022790023
561PhosphorylationKLKELNGTAPEEKKL
HHHHHCCCCCHHHCC		37.6627180971
590UbiquitinationICNNSSEKPTAQQLQ
HCCCCCCCCCHHHHH		50.01-
622UbiquitinationDILRLSIKHPNVNEN
HHHHHHCCCCCCCCC		50.0322790023
651SuccinylationNLLNPKGKPANQLLA
HHHCCCCCCHHHHHH		47.2723806337
651AcetylationNLLNPKGKPANQLLA
HHHCCCCCCHHHHHH		47.2723806337
681PhosphorylationLMMSQRESLMSHAIE
HHHHHHHHHHHHHHH		31.4026643407
684PhosphorylationSQRESLMSHAIELKS
HHHHHHHHHHHHHCC		18.3026643407
772UbiquitinationLGVDSQIKKYVSVSE
CCCCHHHHHHCCCCC		30.3422790023
773AcetylationGVDSQIKKYVSVSEP
CCCHHHHHHCCCCCC		53.1422826441
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLAP_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLAP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLAP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PLAP_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLAP_MOUSE

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Related Literatures of Post-Translational Modification

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