FBX32_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX32_MOUSE
• UniProt AC: Q9CPU7
• Protein Name: F-box only protein 32
• Gene Name: Fbxo32
• Organism: Mus musculus (Mouse).
• Sequence Length: 355
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity)..
• Protein Sequence: MPFLGQDWRSPGQSWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYSKENLFSSLNYDVAAKKRKKDIQNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNSIQISRPAFKGLTITDLPVCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKRLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRREQYGVTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
260	Phosphorylation	APDLHVLSEDRLLWK CCCCEECCHHHHHHH	36.04	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX32_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX32_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX32_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN2_HUMAN	ACTN2	physical	15489953
PP2BA_HUMAN	PPP3CA	physical	15489953
MYOD1_MOUSE	Myod1	physical	15531760
MYOD1_MOUSE	Myod1	physical	22673621
DESM_MOUSE	Des	physical	22673621
VIME_MOUSE	Vim	physical	22673621
CJ076_MOUSE	9130011E15Rik	physical	22673621
ACTS_MOUSE	Acta1	physical	22673621
ACTB_MOUSE	Actb	physical	22673621
ACTBL_MOUSE	Actbl2	physical	22673621
ACTG_MOUSE	Actg1	physical	22673621
ADRM1_MOUSE	Adrm1	physical	22673621
KAD1_MOUSE	Ak1	physical	22673621
ALDR_MOUSE	Akr1b3	physical	22673621
ALBU_MOUSE	Alb	physical	22673621
ALDOA_MOUSE	Aldoa	physical	22673621
ALDOC_MOUSE	Aldoc	physical	22673621
ANXA1_MOUSE	Anxa1	physical	22673621
ANXA2_MOUSE	Anxa2	physical	22673621
GDIR1_MOUSE	Arhgdia	physical	22673621
ASAP2_MOUSE	Asap2	physical	22673621
ATPA_MOUSE	Atp5a1	physical	22673621
ATPB_MOUSE	Atp5b	physical	22673621
ATPD_MOUSE	Atp5d	physical	22673621
CAND1_MOUSE	Cand1	physical	22673621
CAND2_MOUSE	Cand2	physical	22673621
CAH3_MOUSE	Car3	physical	22673621
TCPB_MOUSE	Cct2	physical	22673621
TCPH_MOUSE	Cct7	physical	22673621
COF1_MOUSE	Cfl1	physical	22673621
KCRM_MOUSE	Ckm	physical	22673621
CLPP_MOUSE	Clpp	physical	22673621
CO1A1_MOUSE	Col1a1	physical	22673621
CO6A1_MOUSE	Col6a1	physical	22673621
CSN4_MOUSE	Cops4	physical	22673621
KC1A_MOUSE	Csnk1a1	physical	22673621
CUL1_MOUSE	Cul1	physical	22673621
CYC_MOUSE	Cycs	physical	22673621
DESP_MOUSE	Dsp	physical	22673621
EF1A1_MOUSE	Eef1a1	physical	22673621
EF1B_MOUSE	Eef1b2	physical	22673621
EF1G_MOUSE	Eef1g	physical	22673621
EF2_MOUSE	Eef2	physical	22673621
EIF2A_MOUSE	Eif2a	physical	22673621
EIF3B_MOUSE	Eif3b	physical	22673621
EIF3E_MOUSE	Eif3e	physical	22673621
EIF3F_MOUSE	Eif3f	physical	22673621
IF4A1_MOUSE	Eif4a1	physical	22673621
IF4B_MOUSE	Eif4b	physical	22673621
ENOB_MOUSE	Eno3	physical	22673621
SYEP_MOUSE	Eprs	physical	22673621
FBLN2_MOUSE	Fbln2	physical	22673621
GBRA1_MOUSE	Gabra1	physical	22673621
G3P_MOUSE	Gapdh	physical	22673621
H2AJ_MOUSE	H2afj	physical	22673621
HBB1_MOUSE	Hbb-b1	physical	22673621
HBB2_MOUSE	Hbb-b2	physical	22673621
ROA1_MOUSE	Hnrnpa1	physical	22673621
ROA2_MOUSE	Hnrnpa2b1	physical	22673621
HNRPK_MOUSE	Hnrnpk	physical	22673621
HS90A_MOUSE	Hsp90aa1	physical	22673621
HSP7C_MOUSE	Hspa8	physical	22673621
GRP75_MOUSE	Hspa9	physical	22673621
CH60_MOUSE	Hspd1	physical	22673621
IMDH2_MOUSE	Impdh2	physical	22673621
INF2_MOUSE	Inf2	physical	22673621
PLAK_MOUSE	Jup	physical	22673621
SYK_MOUSE	Kars	physical	22673621
K2C1_MOUSE	Krt1	physical	22673621
K1C14_MOUSE	Krt14	physical	22673621
LDB3_MOUSE	Ldb3	physical	22673621
LDHA_MOUSE	Ldha	physical	22673621
ENOA_MOUSE	Eno1	physical	22673621
LRC47_MOUSE	Lrrc47	physical	22673621
LYZ1_MOUSE	Lyz1	physical	22673621
MARCS_MOUSE	Marcks	physical	22673621
MDHM_MOUSE	Mdh2	physical	22673621
MTA70_MOUSE	Mettl3	physical	22673621
AFAD_MOUSE	Mllt4	physical	22673621
RM01_MOUSE	Mrpl1	physical	22673621
MAP4_MOUSE	Map4	physical	22673621
MYBPH_MOUSE	Mybph	physical	22673621
MYH1_MOUSE	Myh1	physical	22673621
MYH3_MOUSE	Myh3	physical	22673621
MYH4_MOUSE	Myh4	physical	22673621
MYH6_MOUSE	Myh6	physical	22673621
MYH8_MOUSE	Myh8	physical	22673621
MYL1_MOUSE	Myl1	physical	22673621
MYL6_MOUSE	Myl6	physical	22673621
MYL6B_MOUSE	Myl6b	physical	22673621
MLRS_MOUSE	Mylpf	physical	22673621
NACAM_MOUSE	Naca	physical	22673621
NACA_MOUSE	Naca	physical	22673621
PCBP1_MOUSE	Pcbp1	physical	22673621
PDIA6_MOUSE	Pdia6	physical	22673621
PGAM2_MOUSE	Pgam2	physical	22673621
PK3CA_MOUSE	Pik3ca	physical	22673621
KPYM_MOUSE	Pkm	physical	22673621
PKP1_MOUSE	Pkp1	physical	22673621
PRD16_MOUSE	Prdm16	physical	22673621
GLU2B_MOUSE	Prkcsh	physical	22673621
PRS6A_MOUSE	Psmc3	physical	22673621
PRS8_MOUSE	Psmc5	physical	22673621
PSMD2_MOUSE	Psmd2	physical	22673621
CAVN1_MOUSE	Ptrf	physical	22673621
PURB_MOUSE	Purb	physical	22673621
PRVA_MOUSE	Pvalb	physical	22673621
RL14_MOUSE	Rpl14	physical	22673621
RL18_MOUSE	Rpl18	physical	22673621
RL22_MOUSE	Rpl22	physical	22673621
RL6_MOUSE	Rpl6	physical	22673621
RL7_MOUSE	Rpl7	physical	22673621
RLA0_MOUSE	Rplp0	physical	22673621
RLA2_MOUSE	Rplp2	physical	22673621
RS13_MOUSE	Rps13	physical	22673621
RS19_MOUSE	Rps19	physical	22673621
RS3A_MOUSE	Rps3a1	physical	22673621
RTN2_MOUSE	Rtn2	physical	22673621
SIG12_MOUSE	Siglece	physical	22673621
SKP1_MOUSE	Skp1a	physical	22673621
RU17_MOUSE	Snrnp70	physical	22673621
SODC_MOUSE	Sod1	physical	22673621
SRCA_MOUSE	Srl	physical	22673621
SYNCI_MOUSE	Sync	physical	22673621
TELO2_MOUSE	Telo2	physical	22673621
THOP1_MOUSE	Thop1	physical	22673621
TNNC2_MOUSE	Tnnc2	physical	22673621
TPM1_MOUSE	Tpm1	physical	22673621
TBA1A_MOUSE	Tuba1a	physical	22673621
TBB2B_MOUSE	Tubb2b	physical	22673621
TBB6_MOUSE	Tubb6	physical	22673621
UBP2L_MOUSE	Ubap2l	physical	22673621
RL40_MOUSE	Uba52	physical	22673621
UB2V1_MOUSE	Ube2v1	physical	22673621
UB2V2_MOUSE	Ube2v2	physical	22673621
UBQL2_MOUSE	Ubqln2	physical	22673621
VINC_MOUSE	Vcl	physical	22673621
TERA_MOUSE	Vcp	physical	22673621
1433B_MOUSE	Ywhab	physical	22673621
1433G_MOUSE	Ywhag	physical	22673621
1433Z_MOUSE	Ywhaz	physical	22673621
IKBA_MOUSE	Nfkbia	physical	21617130
CUL1_MOUSE	Cul1	physical	15531760
SKP1_MOUSE	Skp1a	physical	15531760
UB2R1_MOUSE	Cdc34	physical	21617130
HDAC6_MOUSE	Hdac6	physical	25516595
MYCD_MOUSE	Myocd	physical	27403897

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.