TNNC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNC2_MOUSE
• UniProt AC: P20801
• Protein Name: Troponin C, skeletal muscle
• Gene Name: Tnnc2
• Organism: Mus musculus (Mouse).
• Sequence Length: 160
• Protein Description: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments..
• Protein Sequence: MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDAEELAEIFRASGEHVTEEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTDQQAEAR ------CCHHHHHHH	42.38	-
13	Phosphorylation	AEARSYLSEEMIAEF HHHHHHCCHHHHHHH	24.23	28464351
36	Phosphorylation	ADGGGDISVKELGTV CCCCCCEEHHHHHHH	31.69	-
38	Ubiquitination	GGGDISVKELGTVMR CCCCEEHHHHHHHHH	40.19	-
50	Phosphorylation	VMRMLGQTPTKEELD HHHHHCCCCCHHHHH	31.00	28542873
52	Phosphorylation	RMLGQTPTKEELDAI HHHCCCCCHHHHHHH	55.25	25521595
89	Ubiquitination	RQMKEDAKGKSEEEL HHHHHHHCCCCHHHH	78.26	-
91	Ubiquitination	MKEDAKGKSEEELAE HHHHHCCCCHHHHHH	54.72	-
92	Phosphorylation	KEDAKGKSEEELAEC HHHHCCCCHHHHHHH	59.93	22210690
134	Phosphorylation	VTEEEIESLMKDGDK CCHHHHHHHHHHCCC	39.15	22210690
137	Ubiquitination	EEIESLMKDGDKNND HHHHHHHHHCCCCCC	64.95	-
141	Ubiquitination	SLMKDGDKNNDGRID HHHHHCCCCCCCCCC	64.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TNNC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.