MTA70_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTA70_MOUSE
• UniProt AC: Q8C3P7
• Protein Name: N6-adenosine-methyltransferase subunit METTL3
• Gene Name: Mettl3 {ECO:0000312|MGI:MGI:1927165}
• Organism: Mus musculus (Mouse).
• Sequence Length: 580
• Subcellular Localization: Nucleus . Nucleus speckle . Cytoplasm . Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components (PubMed:24394384). In response to ultraviolet irradiation, colocalizes to DNA damag
• Protein Description: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and haematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. [PubMed: 25456834]
• Protein Sequence: MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSSGPKPSTTSVAPELATDPELEKKLLHHLSDLALTLPTDAVSIRLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVADKKGLGEVAGTIAGQKRRAEQDLTTVTTFASSLASGLASSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACVDSESPGSKEHMPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDTWSSIQ ------CCCCHHHHH	43.69	-
2	Phosphorylation	------MSDTWSSIQ ------CCCCHHHHH	43.69	-
17	Phosphorylation	AHKKQLDSLRERLQR HHHHHHHHHHHHHHH	37.61	-
30	Phosphorylation	QRRRKQDSGHLDLRN HHHHHHHCCCCCCCC	26.14	26824392
43	Phosphorylation	RNPEAALSPTFRSDS CCHHHHHCCCCCCCC	19.71	26824392
45	Phosphorylation	PEAALSPTFRSDSPV HHHHHCCCCCCCCCC	28.45	28833060
48	Phosphorylation	ALSPTFRSDSPVPTA HHCCCCCCCCCCCCC	37.94	21082442
50	Phosphorylation	SPTFRSDSPVPTAPT CCCCCCCCCCCCCCC	29.10	25521595
54	Phosphorylation	RSDSPVPTAPTSSGP CCCCCCCCCCCCCCC	45.57	21659605
57	Phosphorylation	SPVPTAPTSSGPKPS CCCCCCCCCCCCCCC	32.82	26160508
58	Phosphorylation	PVPTAPTSSGPKPST CCCCCCCCCCCCCCC	32.04	26160508
59	Phosphorylation	VPTAPTSSGPKPSTT CCCCCCCCCCCCCCC	62.69	26160508
64	Phosphorylation	TSSGPKPSTTSVAPE CCCCCCCCCCCCCHH	50.90	26160508
65	Phosphorylation	SSGPKPSTTSVAPEL CCCCCCCCCCCCHHH	31.45	26160508
66	Phosphorylation	SGPKPSTTSVAPELA CCCCCCCCCCCHHHC	26.07	26160508
67	Phosphorylation	GPKPSTTSVAPELAT CCCCCCCCCCHHHCC	19.17	26160508
74	Phosphorylation	SVAPELATDPELEKK CCCHHHCCCHHHHHH	65.79	25777480
105	Phosphorylation	VSIRLAISTPDAPAT EEEEEEECCCCCCCC	28.42	25338131
154	Phosphorylation	YADHSKLSAMMGAVA ECCHHHHHHHHHHHH	20.18	29514104
219	Phosphorylation	KSRKHAASDVDLEIE HHHHHHHCHHHHHHH	38.66	26745281
243	Phosphorylation	EQQSKKVSQEILELL HHHHHHHHHHHHHHH	30.86	27600695
253	Phosphorylation	ILELLNTTTAKEQSI HHHHHCCCCHHHHHH	24.55	-
263	Acetylation	KEQSIVEKFRSRGRA HHHHHHHHHHHCCCH	34.87	23806337
339	Phosphorylation	EIDACVDSESPGSKE EECEECCCCCCCCCC	21.41	25293948
341	Phosphorylation	DACVDSESPGSKEHM CEECCCCCCCCCCCC	38.21	25293948
344	Phosphorylation	VDSESPGSKEHMPSQ CCCCCCCCCCCCCHH	37.95	25293948
350	Phosphorylation	GSKEHMPSQELALTQ CCCCCCCHHHHEEEE	28.81	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTA70_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTA70_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTA70_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MTA70_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.