CLPP_MOUSE - dbPTM
CLPP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLPP_MOUSE
UniProt AC O88696
Protein Name ATP-dependent Clp protease proteolytic subunit, mitochondrial
Gene Name Clpp
Organism Mus musculus (Mouse).
Sequence Length 272
Subcellular Localization Mitochondrion matrix .
Protein Description Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (By similarity)..
Protein Sequence MWPRVLLGEARVAVDGCRALLSRLAVHFSPPWTAVSCSPLRRSLHGTATRAFPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPELVQKETATAPTDPPAPTST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
196AcetylationIQAEEIMKLKKQLYN
HHHHHHHHHHHHHHH		63.9223806337
196SuccinylationIQAEEIMKLKKQLYN
HHHHHHHHHHHHHHH		63.92-
196SuccinylationIQAEEIMKLKKQLYN
HHHHHHHHHHHHHHH		63.9223806337
199AcetylationEEIMKLKKQLYNIYA
HHHHHHHHHHHHHHH		56.8423806337
199SuccinylationEEIMKLKKQLYNIYA
HHHHHHHHHHHHHHH		56.8423806337
199MalonylationEEIMKLKKQLYNIYA
HHHHHHHHHHHHHHH		56.8426320211
207AcetylationQLYNIYAKHTKQSLQ
HHHHHHHHHCHHHHH		34.5323576753
210AcetylationNIYAKHTKQSLQVIE
HHHHHHCHHHHHHHH		37.2923201123
224MethylationESAMERDRYMSPMEA
HHHHHHCCCCCHHHH		34.96-
239AcetylationQEFGILDKVLVHPPQ
HHHCCCCEEEECCCC		33.7423954790
239SuccinylationQEFGILDKVLVHPPQ
HHHCCCCEEEECCCC		33.7423954790
270PhosphorylationPTDPPAPTST-----
CCCCCCCCCC-----		47.2925293948
271PhosphorylationTDPPAPTST------
CCCCCCCCC------		30.9423684622
272PhosphorylationDPPAPTST-------
CCCCCCCC-------		45.1425293948
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLPP_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLPP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLPP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CLPP_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLPP_MOUSE

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Related Literatures of Post-Translational Modification

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