ENOB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENOB_MOUSE
• UniProt AC: P21550
• Protein Name: Beta-enolase
• Gene Name: Eno3
• Organism: Mus musculus (Mouse).
• Sequence Length: 434
• Subcellular Localization: Cytoplasm . Localized to the Z line. Some colocalization with CKM at M-band (By similarity)..
• Protein Description: Appears to have a function in striated muscle development and regeneration..
• Protein Sequence: MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKARYLGKGVLKAVEHINKTLGPALLEKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAEKGVPLYRHIADLAGNPDLVLPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKEAMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKVVIGMDVAASEFYRNGKYDLDFKSPDDPARHISGEKLGELYKNFIQNYPVVSIEDPFDQDDWATWTSFLSGVDIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDKAVFAGRKFRNPKAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMQKIFAR ------CCHHHHHHH	14.76	-
5	Acetylation	---MAMQKIFAREIL ---CCHHHHHHHHHH	27.06	24062335
5	Succinylation	---MAMQKIFAREIL ---CCHHHHHHHHHH	27.06	26388266
5	Ubiquitination	---MAMQKIFAREIL ---CCHHHHHHHHHH	27.06	-
14	Phosphorylation	FAREILDSRGNPTVE HHHHHHHCCCCCEEE	38.35	22210690
19	Phosphorylation	LDSRGNPTVEVDLHT HHCCCCCEEEEEEEC	33.04	22210690
26	Phosphorylation	TVEVDLHTAKGRFRA EEEEEEECCCCCEEE	37.04	-
28	Ubiquitination	EVDLHTAKGRFRAAV EEEEECCCCCEEEEC	52.34	-
28	Succinylation	EVDLHTAKGRFRAAV EEEEECCCCCEEEEC	52.34	26388266
37	Phosphorylation	RFRAAVPSGASTGIY CEEEECCCCCCCCHH	40.15	28542873
40	Phosphorylation	AAVPSGASTGIYEAL EECCCCCCCCHHHHH	30.60	25521595
41	Phosphorylation	AVPSGASTGIYEALE ECCCCCCCCHHHHHH	27.37	25521595
44	Phosphorylation	SGASTGIYEALELRD CCCCCCHHHHHHCCC	9.11	26824392
54	Ubiquitination	LELRDGDKARYLGKG HHCCCCHHHHHHCHH	40.05	22790023
60	Ubiquitination	DKARYLGKGVLKAVE HHHHHHCHHHHHHHH	43.16	22790023
64	Ubiquitination	YLGKGVLKAVEHINK HHCHHHHHHHHHHHH	48.24	22790023
71	Ubiquitination	KAVEHINKTLGPALL HHHHHHHHHHCHHHH	44.52	22790023
72	Phosphorylation	AVEHINKTLGPALLE HHHHHHHHHCHHHHH	32.24	28464351
80	Succinylation	LGPALLEKKLSVVDQ HCHHHHHHHHCCCCH	60.01	26388266
80	Ubiquitination	LGPALLEKKLSVVDQ HCHHHHHHHHCCCCH	60.01	-
80	Acetylation	LGPALLEKKLSVVDQ HCHHHHHHHHCCCCH	60.01	24062335
81	Ubiquitination	GPALLEKKLSVVDQE CHHHHHHHHCCCCHH	36.30	22790023
83	Phosphorylation	ALLEKKLSVVDQEKV HHHHHHHCCCCHHHH	29.04	27742792
89	Acetylation	LSVVDQEKVDKFMIE HCCCCHHHHHHEEEE	50.53	23954790
92	Ubiquitination	VDQEKVDKFMIELDG CCHHHHHHEEEECCC	39.56	22790023
104	Phosphorylation	LDGTENKSKFGANAI CCCCCCCHHCCHHHH	44.81	28464351
119	S-nitrosylation	LGVSLAVCKAGAAEK HHHHHHHHHHCHHHH	1.76	24895380
119	S-nitrosocysteine	LGVSLAVCKAGAAEK HHHHHHHHHHCHHHH	1.76	-
131	Phosphorylation	AEKGVPLYRHIADLA HHHCCCCHHHHHHHC	8.28	19854140
157	Phosphorylation	FNVINGGSHAGNKLA EEEECCCCCCCCCHH	16.15	28542873
176	Phosphorylation	MILPVGASSFKEAMR CEECCCHHHHHHHHH	30.31	23737553
177	Phosphorylation	ILPVGASSFKEAMRI EECCCHHHHHHHHHH	39.54	23737553
179	Ubiquitination	PVGASSFKEAMRIGA CCCHHHHHHHHHHCH	46.65	22790023
179	Acetylation	PVGASSFKEAMRIGA CCCHHHHHHHHHHCH	46.65	19863087
197	Acetylation	HHLKGVIKAKYGKDA HHHHHHHHHHCCCCC	36.10	-
199	Acetylation	LKGVIKAKYGKDATN HHHHHHHHCCCCCCC	49.92	-
202	Ubiquitination	VIKAKYGKDATNVGD HHHHHCCCCCCCCCC	40.89	-
202	Succinylation	VIKAKYGKDATNVGD HHHHHCCCCCCCCCC	40.89	26388266
205	Phosphorylation	AKYGKDATNVGDEGG HHCCCCCCCCCCCCC	40.34	23737553
229	Phosphorylation	EALELLKTAIQAAGY HHHHHHHHHHHHCCC	29.03	23375375
236	Phosphorylation	TAIQAAGYPDKVVIG HHHHHCCCCCEEEEE	11.97	28464351
256	Ubiquitination	SEFYRNGKYDLDFKS HHHHHCCCCCCCCCC	38.86	22790023
263	Phosphorylation	KYDLDFKSPDDPARH CCCCCCCCCCCHHHH	33.29	24899341
272	Phosphorylation	DDPARHISGEKLGEL CCHHHHCCHHHHHHH	34.47	23737553
275	Ubiquitination	ARHISGEKLGELYKN HHHCCHHHHHHHHHH	66.38	22790023
326	Acetylation	DLTVTNPKRIAQAVE CCEECCHHHHHHHHH	59.51	30985915
334	Acetylation	RIAQAVEKKACNCLL HHHHHHHHHHHCEEE	38.79	19863097
334	Succinylation	RIAQAVEKKACNCLL HHHHHHHHHHHCEEE	38.79	26388266
335	Succinylation	IAQAVEKKACNCLLL HHHHHHHHHHCEEEE	44.67	26388266
337	S-nitrosylation	QAVEKKACNCLLLKV HHHHHHHHCEEEEEH	5.19	24895380
339	S-nitrosylation	VEKKACNCLLLKVNQ HHHHHHCEEEEEHHH	2.59	24895380
357	S-nitrosylation	VTESIQACKLAQSNG HHHHHHHHHHHHHCC	1.81	24895380
357	S-nitrosocysteine	VTESIQACKLAQSNG HHHHHHHHHHHHHCC	1.81	-
362	Phosphorylation	QACKLAQSNGWGVMV HHHHHHHHCCCEEEE	31.53	26745281
370	Phosphorylation	NGWGVMVSHRSGETE CCCEEEEECCCCCCC	8.62	28638064
373	Phosphorylation	GVMVSHRSGETEDTF EEEEECCCCCCCCCH	35.24	22210690
376	Phosphorylation	VSHRSGETEDTFIAD EECCCCCCCCCHHHH	42.56	22210690
379	Phosphorylation	RSGETEDTFIADLVV CCCCCCCCHHHHHHH	15.65	28464351
389	S-nitrosylation	ADLVVGLCTGQIKTG HHHHHHHHCCCCCCC	3.10	24895380
389	S-nitrosocysteine	ADLVVGLCTGQIKTG HHHHHHHHCCCCCCC	3.10	-
394	Ubiquitination	GLCTGQIKTGAPCRS HHHCCCCCCCCCCCH	32.78	-
399	S-nitrosylation	QIKTGAPCRSERLAK CCCCCCCCCHHHHHH	8.08	21278135
399	S-nitrosocysteine	QIKTGAPCRSERLAK CCCCCCCCCHHHHHH	8.08	-
406	Ubiquitination	CRSERLAKYNQLMRI CCHHHHHHHHHHHHH	49.69	27667366
420	Acetylation	IEEALGDKAVFAGRK HHHHHCCCHHHCCCC	44.65	23236377
420	Ubiquitination	IEEALGDKAVFAGRK HHHHHCCCHHHCCCC	44.65	22790023
492	Ubiquitination	----------------------------------------------------------------- -----------------------------------------------------------------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENOB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENOB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENOB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ENOB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.