dbPTM

RTN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTN2_MOUSE
UniProt AC	O70622
Protein Name	Reticulon-2
Gene Name	Rtn2
Organism	Mus musculus (Mouse).
Sequence Length	471
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPQQSGLGDSLESIPSLSQSPEPGRRGDPDPVPPAERPLEELRLRLDQLGWVVRSAGSGEDSATSSSTPLENEEPDGLEASEAGEETNLELRLAQSLHLQLEVLTPQLSPSSGTPQAHTPSPQRSQDSNSGPDDEPLLNVVEEHWRLLEQEPITAQCLDSTDQSEFMLEPLLLVADLLYWKDTRTSGAVFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDGTNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGTLAPTASVSGSKAKAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	LHTAREFSEDEEEET HHHHHCCCCCCCCCC	39.11	15345747
81	Phosphorylation	GSGGRRDSVVRRPRP CCCCCCCCCCCCCCC	22.24	29899451
223	Phosphorylation	HTPSPQRSQDSNSGP CCCCCCCCCCCCCCC	32.85	20415495
226	Phosphorylation	SPQRSQDSNSGPDDE CCCCCCCCCCCCCCH	25.84	22817900
228	Phosphorylation	QRSQDSNSGPDDEPL CCCCCCCCCCCCHHH	56.51	22817900
279	Ubiquitination	VADLLYWKDTRTSGA HHHHHHHCCCCCCHH	35.35	22790023
364	Phosphorylation	RLSQQIASHVVSTAT HHHHHHHHHHHHHHH	20.60	28464351
450	Ubiquitination	IKAKIRAKIPGTGTL HHHHHHCCCCCCCCC	39.32	22790023
454	Phosphorylation	IRAKIPGTGTLAPTA HHCCCCCCCCCCCCE	22.95	22006019
460	Phosphorylation	GTGTLAPTASVSGSK CCCCCCCCEECCCCC	26.42	23737553
462	Phosphorylation	GTLAPTASVSGSKAK CCCCCCEECCCCCCC	21.21	23737553
464	Phosphorylation	LAPTASVSGSKAKAE CCCCEECCCCCCCCC	34.55	23737553
466	Phosphorylation	PTASVSGSKAKAE-- CCEECCCCCCCCC--	23.18	28464351
467	Ubiquitination	TASVSGSKAKAE--- CEECCCCCCCCC---	58.39	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RTN2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTN2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RTN2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTN2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, AND MASSSPECTROMETRY.	15345747 [Abstract]