SYNCI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNCI_MOUSE
• UniProt AC: Q9EPM5
• Protein Name: Syncoilin
• Gene Name: Sync
• Organism: Mus musculus (Mouse).
• Sequence Length: 470
• Subcellular Localization: Cytoplasm, perinuclear region . In skeletal muscle, colocalizes with DES and DTNA, and is localized at the myotendinous and neuromuscular junctions, sarcolemma and Z-lines. In myotubes, detected in a punctate cytoplasmic pattern.
• Protein Description: Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins..
• Protein Sequence: MASPEPLRGGDGARASREPHTEASFPLQESESPKEAKTFNPEATLSLEGTVNLEDILYLGASGDFEESFYEEEYEKPALTLFIDESRQPDEALGLEEPVRPEEMLSVEESVTPDEVQISEQPVEPAKSPTACEGEMVATEGSLPAQPIPNTEEDPLSVEDLERLEARFQQCVQAVSQLEEERDQLIHELVLLREPALQEVQQVHQDILAAYKLHAQAELERDGLREEIRTVKQKLFKVTKECVAYQYQLECRQQDVAQFADCREALTTRAAQLSEELTQLRDACQKQKEQLQQQLEAPPTQSDGHFLQESRRLSTQFENLMAESRQGLEEEYEPQLLRLLERKEAGTKALQDTQAEIQEMREALRPLEAEARQLQLQNRNLEDQITLVRQKRDEEVQQYREQLEEMEERQRQLRSGVQVQQQKNKEMERLRMSLAEELSTYKAMLPKSLEQADAPTSQAGGVEAQSPGTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPEPLRGG -----CCCCCCCCCC	28.62	26824392
24	Phosphorylation	REPHTEASFPLQESE CCCCCCCCCCCCCCC	22.59	26643407
30	Phosphorylation	ASFPLQESESPKEAK CCCCCCCCCCHHHCC	30.34	28638064
32	Phosphorylation	FPLQESESPKEAKTF CCCCCCCCHHHCCCC	51.02	26824392
37	Ubiquitination	SESPKEAKTFNPEAT CCCHHHCCCCCCCCE	55.53	-
268	Phosphorylation	DCREALTTRAAQLSE HHHHHHHHHHHHHHH	21.11	22871156
314	Phosphorylation	LQESRRLSTQFENLM HHHHHHHHHHHHHHH	20.53	26824392
315	Phosphorylation	QESRRLSTQFENLMA HHHHHHHHHHHHHHH	41.70	26160508
457	O-linked_Glycosylation	EQADAPTSQAGGVEA HHCCCCCCCCCCCCC	19.58	30016717
466	Phosphorylation	AGGVEAQSPGTV--- CCCCCCCCCCCC---	32.14	26824392
469	Phosphorylation	VEAQSPGTV------ CCCCCCCCC------	26.82	24899341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNCI_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNCI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNCI_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SYNCI_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.