FBLN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBLN2_MOUSE
• UniProt AC: P37889
• Protein Name: Fibulin-2
• Gene Name: Fbln2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1221
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN..
• Protein Sequence: MLLQESAGVWLALALVTALTPSPSMAVPWQDCTGAECPLLENCIEEALEPGACCATCVQQGCACEGYQYYDCVQGGFVDGRVPAGQSYFVDFGSTECSCPPGGGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHSGRKYAAGHTVHLSSCRACHCPDAGGELICYQLPGCHGNFSDAEEGDSERQYEDPYSYDQEVAEAEATTAIVNEVQAGAEGPPAALGGGNLPPSSIRVTPWPVALPRPTAAAALGPPAPVQAKARRVTLDTEEDEEEEEEETLVTEPPTAGSPGRLDSLPTRSPARPGFPVQEKEAEAKAGPEENLIPDAQVTPRSVMQEGAAPLPRSGLAALSPSLATDSSSEDPVKPSDHPTLSTLPPDRAQVSPSPETPEEIPQHPQLLPRFRAEEDIDPNSVHSVPRGDLDGSTKDLIETCCAAGQQWAIDNDECQEIPENGAQSDICRIAQRQCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPEAAPRRVSEMEMASREALSLGTEAELPNSLPGDDQDECLMLPGELCQHLCINTVGSYRCACFPGFELQGDGRTCRPDRGAPQLDTARESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQVCRVVGDTAMCSCFPGYAIMADGVSCEDQDECLMGTHDCSWKQFCVNTLGSFYCVNHTVLCAEGYILNAHRKCVDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLTDGECTDVDECVTGTHNCQAGFSCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLLEPCRSGFSCINTVGSYTCQRNPLVCGRGYHANEEGSECVDVNECETGVHRCGEGQLCYNLPGSYRCDCKPGFQRDAFGRTCIDVNECWVSPGRLCQHTCENTPGSYRCSCAAGFLLAADGKHCEDVNECETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHNCSEAETCHNIQGSFRCLRFDCPPNYVRVSETKCERTTCQDITECQTSPARITHYQLNFQTGLLVPAHIFRIGPAPAFAGDTISLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDFALDVEMKLWRQGSVTTFLAKMYIFFTTFAP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
144	Acetylation	GCVHSGRKYAAGHTV EEEECCCCEECCCEE	42.65	22826441
179	N-linked_Glycosylation	QLPGCHGNFSDAEEG ECCCCCCCCCCCCCC	15.02	-
362	Phosphorylation	PSLATDSSSEDPVKP HHHCCCCCCCCCCCC	40.32	25338131
386	Phosphorylation	PPDRAQVSPSPETPE CCCCCCCCCCCCCCC	13.95	26824392
388	Phosphorylation	DRAQVSPSPETPEEI CCCCCCCCCCCCCCC	28.06	25338131
415	Phosphorylation	EEDIDPNSVHSVPRG CCCCCCCCCCCCCCC	26.96	26824392
418	Phosphorylation	IDPNSVHSVPRGDLD CCCCCCCCCCCCCCC	31.49	26824392
475	Acetylation	QCCISYLKEKSCVAG HHHHHHHHHCCCEEE	55.66	22826441
497	N-linked_Glycosylation	ETCGAEDNDTCGVSL CCCCCCCCCCCCEEH	37.69	-
568	Phosphorylation	EAAPRRVSEMEMASR CCCCCHHHHHHHHHH	29.43	24719451
574	Phosphorylation	VSEMEMASREALSLG HHHHHHHHHHHHHCC	29.37	26824392
737	N-linked_Glycosylation	LGSFYCVNHTVLCAE CCCEEEECCEEEECC	22.88	-
1072	N-linked_Glycosylation	ECALGTHNCSEAETC HCCCCCCCCCHHHHH	30.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBLN2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBLN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBLN2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FBLN2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.