PRD16_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRD16_MOUSE
• UniProt AC: A2A935
• Protein Name: PR domain zinc finger protein 16 {ECO:0000305}
• Gene Name: Prdm16 {ECO:0000312|MGI:MGI:1917923}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1275
• Subcellular Localization: Nucleus .
• Protein Description: Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. May regulate granulocytes differentiation..
• Protein Sequence: MRSKARARKLAKSDGDVVNNMYEPDPDLLAGQSAEEETEDGILSPIPMGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIPIPPDFELRESSIPGAGLGIWAKRKMEIGERFGPYVVTPRAALKEADFGWEMLTDTEVSSQESCIKKQISEDLGSEKFCVDANQAGSGSWLKYIRVACSCDDQNLAMCQINEQIYYKVIKDIEPGEELLVHVKEGAYSLGVMAPSLDEDPTFRCDECDELFQCRLDLRRHKKYACSSAGAQLYEGLGEELKPEGLGVGSDGQAHECKDCERMFPNKYSLEQHMIVHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKRFECENCVKVFTDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGSIFTPGLPLTPSPMMDKTKPSPTLNHGGLGFSEYFPSRPHPGSLPFSAAPPAFPALTPGFPGIFPPSLYPRPPLLPPTPLLKSPLNHAQDAKLPSPLGNPALPLVSAVSNSSQGATAATGSEEKFDGRLEDAYAEKVKNRSPDMSDGSDFEDINTTTGTDLDTTTGTGSDLDSDLDSDRDKGKDKGKPVESKPEFGGASVPPGAMNSVAEVPAFYSQHSFFPPPEEQLLTASGAAGDSIKAIASIAEKYFGPGFMSMQEKKLGSLPYHSVFPFQFLPNFPHSLYPFTDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKEAKPALLAPKVPLIPSSGEEQPLDLSIGSRARASQNGGGREPRKNHVYGERKPGVSEGLPKVCPAQLPQQPSLHYAKPSPFFMDPIYRVEKRKVADPVGVLKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHEGAPVSQHSGVLTNHLGTSASSPTSESDNHALLDEKEDSYFSEIRNFIANSEMNQASTRMDKRPEIQDLDSNPPCPGSASAKPEDVEEEEEEELEEEDDDSLAGKSQEDTVSPTPEPQGVYEDEEDEEPPSLTMGFDHTRRCVEERGGGLLALEPTPTFGKGLDLRRAAEEAFEVKDVLNSTLDSEVLKQTLYRQAKNQAYAMMLSLSEDTPLHAPSQSSLDAWLNITGPSSESGAFNPINHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	TPKEGSPYEAPVYIP CCCCCCCCCCCEECC	26.81	-
116	Phosphorylation	RFGPYVVTPRAALKE HHCCEECCCHHHHHH	9.30	21082442
153	Phosphorylation	QISEDLGSEKFCVDA HHHHHHCCCCEEECH	44.93	18779572
538	Phosphorylation	PPTPLLKSPLNHAQD CCCCCCCCCCCCCCC	34.29	29550500
837	Phosphorylation	GERKPGVSEGLPKVC CCCCCCCCCCCCCCC	31.68	25367039
853	Phosphorylation	AQLPQQPSLHYAKPS CCCCCCCCCCCCCCC	24.36	25367039
856	Phosphorylation	PQQPSLHYAKPSPFF CCCCCCCCCCCCCCC	22.93	25367039
860	Phosphorylation	SLHYAKPSPFFMDPI CCCCCCCCCCCCCCC	33.36	25367039
868	Phosphorylation	PFFMDPIYRVEKRKV CCCCCCCHHHHCCCC	17.62	25367039
886	Phosphorylation	VGVLKEKYLRPSPLL CCHHCCCCCCCCCCC	14.72	25777480
890	Phosphorylation	KEKYLRPSPLLFHPQ CCCCCCCCCCCCCCC	23.03	25777480
899	Phosphorylation	LLFHPQMSAIETMTE CCCCCCCHHHHHHHH	22.35	25777480
903	Phosphorylation	PQMSAIETMTEKLES CCCHHHHHHHHHHHH	24.23	25777480
905	Phosphorylation	MSAIETMTEKLESFA CHHHHHHHHHHHHHH	37.07	25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRD16_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRD16_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRD16_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRD16_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.