PRS6A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRS6A_MOUSE
• UniProt AC: O88685
• Protein Name: 26S proteasome regulatory subunit 6A
• Gene Name: Psmc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 442
• Subcellular Localization: Cytoplasm . Nucleus . Colocalizes with TRIM5 in cytoplasmic bodies.
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides..
• Protein Sequence: MQEMNLLPTPESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQAKKKANLQYYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	QEMNLLPTPESPVTR CCCCCCCCCCCCCCH	39.39	20469934
12	Phosphorylation	NLLPTPESPVTRQEK CCCCCCCCCCCHHHH	26.35	23527152
15	Phosphorylation	PTPESPVTRQEKMAT CCCCCCCCHHHHHHH	29.98	26824392
19	Ubiquitination	SPVTRQEKMATVWDE CCCCHHHHHHHHHHH	26.04	-
19	Acetylation	SPVTRQEKMATVWDE CCCCHHHHHHHHHHH	26.04	23236377
22	Phosphorylation	TRQEKMATVWDEAEQ CHHHHHHHHHHHHHH	20.73	28059163
38	Ubiquitination	GIGEEVLKMSTEEIV CCCHHHHHCCHHHHH	35.66	-
40	Phosphorylation	GEEVLKMSTEEIVQR CHHHHHCCHHHHHHH	30.95	25521595
56	Ubiquitination	RLLDSEIKIMKSEVL HHHHHHHHHCHHHHH	32.47	-
59	Ubiquitination	DSEIKIMKSEVLRVT HHHHHHCHHHHHHHH	47.11	-
59	Malonylation	DSEIKIMKSEVLRVT HHHHHHCHHHHHHHH	47.11	26320211
73	Acetylation	THELQAMKDKIKENS HHHHHHHHHHHHHCH	59.91	23954790
73	Ubiquitination	THELQAMKDKIKENS HHHHHHHHHHHHHCH	59.91	-
82	Ubiquitination	KIKENSEKIKVNKTL HHHHCHHHHCCCCHH	47.88	-
128	Ubiquitination	KGKCAVIKTSTRQTY CCCEEEEECCCCCEE	29.80	-
128	Malonylation	KGKCAVIKTSTRQTY CCCEEEEECCCCCEE	29.80	26320211
135	Phosphorylation	KTSTRQTYFLPVIGL ECCCCCEEEEEEEEE	8.52	23023260
147	Ubiquitination	IGLVDAEKLKPGDLV EEEEEHHHCCCCCEE	64.63	-
149	Ubiquitination	LVDAEKLKPGDLVGV EEEHHHCCCCCEECC	59.01	-
176	Ubiquitination	TEYDSRVKAMEVDER CCCHHHCEEEECCCC	40.69	-
212	Ubiquitination	IVLPMNHKEKFENLG HHCCCCCHHHHHHCC	58.56	-
214	Acetylation	LPMNHKEKFENLGIQ CCCCCHHHHHHCCCC	63.88	23236377
214	Ubiquitination	LPMNHKEKFENLGIQ CCCCCHHHHHHCCCC	63.88	-
224	Ubiquitination	NLGIQPPKGVLMYGP HCCCCCCCCEEEECC	69.23	-
236	Ubiquitination	YGPPGTGKTLLARAC ECCCCCCHHHHHHHH	35.52	-
248	Ubiquitination	RACAAQTKATFLKLA HHHHHHCHHHHHHHH	33.09	-
248	Malonylation	RACAAQTKATFLKLA HHHHHHCHHHHHHHH	33.09	26320211
253	Ubiquitination	QTKATFLKLAGPQLV HCHHHHHHHHCHHHH	31.90	-
279	Ubiquitination	RDAFALAKEKAPSII HHHHHHHHCCCCEEE	61.67	-
281	Ubiquitination	AFALAKEKAPSIIFI HHHHHHCCCCEEEEE	65.96	-
297	Ubiquitination	ELDAIGTKRFDSEKA CCCCCCCCCCCCCCC	45.94	-
303	Ubiquitination	TKRFDSEKAGDREVQ CCCCCCCCCCCHHHH	62.72	-
375	Ubiquitination	IMQIHSRKMNVSPDV HHHHHHCCCCCCCCC	37.53	-
379	Phosphorylation	HSRKMNVSPDVNYEE HHCCCCCCCCCCHHH	15.46	29472430
403	Glutathionylation	GAQCKAVCVEAGMIA CCCCEEEHHHHHHHH	2.46	24333276

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRS6A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRS6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRS6A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRS8_MOUSE	Psmc5	physical	21883213
PSB5_MOUSE	Psmb5	physical	21883213

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.